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Table 3 In vitro drug sensitivity of two RSA positive and four RSA negative P. falciparum isolates to artemisinin, artesunate, dihydroartemisinin, artemether, amodiaquine and lumefantrine

From: Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana

Test drugs (IC50 nM, 95% CI)

 

ART

AS

DHA

AM

LUM

AQ

RSA%

3D7

4.58

(4.17–5.00)

2.75

(2.66–2.85)

4.08

(3.76–4.41)

4.60

(4.38–4.82)

8.52

(7.49–9.55)

7.16

(6.40–7.93)

0.0

D30

4.65

(3.19–6.11)

6.17

(5.08–7.25)

5.35

(3.76–6.93)

7.23

(5.92–8.55)

15.71

(13.43–17.98)

11.8

(8.91–14.69)

13.0

D10

10.81

(9.69–11.94)

9.28

(8.22–10.35)

11.78

(10.31–13.25)

7.21

(6.33–8.10)

10.28

(9.59–10.96)

11.87

(10.83–12.91)

19.0

P52

12.93

(11.22–14.65)

6.64

(6.19–7.10)

5.18

(4.16–6.20)

5.95

(5–60-9.00)

9.16

(8.79–9.53)

11.4

(10.9–11.89)

0.0

P32

6.43

(5.35–7.5)

6.06

(5.37–6.74)

4.55

(3.42–5.68)

7.49

(6.03–8.95)

16.43

(14.44–18.41)

15.02

(12.41–17.63)

0.0

S22

5.75

(4.38–7.12)

6.33

(5.10–7.56)

6.70

(5.93–7.46)

6.71

(5.41–8.01)

11.26

(10.46–12.06)

21.78

(18.54–225.0)

0.0

S19

5.09

(2.95–7.23)

5.13

(3.5–6.77)

3.57

(2.29–4.85)

8.31

(6.11–10.50)

9.73

(7.9–11.57)

12.23

(8.9–15.55)

0.0

  1. ART artemisinin, AS artesunate, DHA dihydroartemisinin, AM artemether, LUM lumefantrine, AQ amodiaquine. D10 & D30: RSA positive isolates; P52, P32, S22, S19: RSA negative isolates, 3D7: laboratory control strain. NB: All assays were done in triplicate