Table 1 Clinical trials data analysed in this study
From: Quantification of parasite clearance in Plasmodium knowlesi infections
Trial details | Data used in this study (714 patients) | ||
|---|---|---|---|
Trial name (reference) | ACT KNOW [22] | CAN KNOW [23] | |
Trial duration | October 2012 – December 2014 | January 2014 – March 2015 | October 2016 – February 2018 |
Number of patients | 226 | 123 | 365 |
Location | Sabah, Malaysia Kota Marudu District Hospital Kudat District Hospital Pitas District Hospital | Sabah, Malaysia Kota Marudu District Hospital Kudat District Hospital Pitas District Hospital | Sabah, Malaysia Keningau District Hospital Queen Elizabeth Hospital Kota Marudu District Hospital Ranau District Hospital |
Study population | Children (age \(\ge\) 3 years and weight > 10 kg) and adults with uncomplicated P. knowlesi malaria | Children (age \(\ge\) 4 years and weight > 10 kg) and adults with uncomplicated P. knowlesi malaria | Children (age \(\ge\) 12 years) and adults with uncomplicated and severe P. knowlesi malaria |
Anti-malarial treatment | Artesunate–mefloquine Chloroquine | Artemether–lumefantrine Chloroquine | Artemether–lumefantrine Intravenous artesunate followed by artemether–lumefantrine Artemether–lumefantrine followed by intravenous artesunate |
Parasitaemia sampling times | Initial sample (time = 0) and every 6 h post anti-malarial drug administration until the parasitaemia fell below the microscopic detection limit for two consecutive samples, where possible | ||