Table 3 Estimated parasite clearance half-lives (hours) by anti-malarial treatment administered using WWARN PCE^a and Bayesian hierarchical modelling

Uncomplicated malaria

Artemether–lumefantrine (n)

301

320

 Mean (hours)

2.845

1.940

 Median (hours)

2.634

1.940

 95% CI & CrI (hours)

[1.568, 5.254]

[1.808, 2.116]

Artesunate–mefloquine (n)

111

115

 Mean (hours)

3.029

1.929

 Median (hours)

2.529

1.932

 95% CI & CrI (hours)

[1.466, 7.683]

[1.741, 2.137]

Chloroquine (n)

174

176

 Mean (hours)

3.599

2.861

 Median (hours)

3.265

2.865

 95% CI & CrI (hours)

[1.867, 7.324]

[2.689, 3.044]

Severe malaria

Artemether–lumefantrine followed by artesunate (intravenous) (n)

15

16

 Mean (hours)

2.485

1.970

 Median (hours)

2.118

1.961

 95% CI & CrI (hours)

[1.513, 4.867]

[1.622, 2.429]

Artesunate (intravenous) followed by artemether–lumefantrine (n)

77

87

 Mean (hours)

2.532

1.792

 Median (hours)

2.275

1.793

 95% CI & CrI (hours)

[1.252, 4.181]

[1.584, 2.009]