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Table 1 Article inclusion and exclusion criteria for RITAM efficacy scoring

From: A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score

Parameters

Inclusion criteria

Exclusion criteria

Part of the plant studied (Leaves, Stembark, Roots, Fruits, Flowers)

Leaves, Fruits, Stembark, Seeds (In case of activities reported on different parts, the one with best activity is considered for scores)

Flowers and Roots

Extraction solvent—Aqueous., Petroleum Ether, Dichloromethane, Ethanol, Methanol)

The one which gives the best activity

The one with less activity

Location of the study plant part collection (Uganda, E. Africa, Africa)

In Uganda and from all other parts if the active compound is known

Outside Uganda and active anti-malarial compound is not known for the plant species

RITAM SCORE [19]

Test

Test Result Range

Score

In vitro Antiplasmodial Test (µg/mL)

Not tested

0

 < 2

10

2.0 – 5.0

5

5.1 – 10

3

11 – 25

2

26 – 50

1

Activity confirmed in more than one strain of P. falciparum

2

In vivo Antiplasmodial Test in mice (% inhibition)

Not tested

0

100 – 90

10

 

90 – 50

9 – 5

 

50 – 10

5 – 1

 

0

-2