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Table 4 Diagnostic accuracy of microscopy and RDT at low parasite density (qPCR < 200p/µL)

From: Accuracy of diagnosis among clinical malaria patients: comparing microscopy, RDT and a highly sensitive quantitative PCR looking at the implications for submicroscopic infections

Performance metric

Test

RDT

Microscopy

TP (qPCR = 244)

68

16

FP (qPCR negative)

11

10

TN (qPCR = 602)

591

592

FN (qPCR positive)

176

228

Sensitivity % (95% C.I.)

27.9 (22.6–33.8)

6.6 (4.1–10.4)

Specificity % (95% C.I.)

98.2 (96.7–99.0)

98.3 (97.0–99.1)

PPV % (95% C.I.)

86.1 (76.8–92.0)

61.5 (42.5–77.6)

NPV % (95% C.I.)

77.1 (74.0–79.9)

72.2 (69.0–75.2)

Accuracy %

77.9

71.9

kappa value (95% C.I.)

0.326 (0.260–0.392)

0.067 (0.023–0.111)

  1. TP True Positive, FP False Positive, FN = False Negative, TN True Negative, PPV Positive Predictive Value, NPV Negative Predictive Value
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Malaria Journal

ISSN: 1475-2875

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