Confirmed Malaria Parasitemia + Any of the Following |
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Altered mental status |
Prostration |
More than two seizures in 24 h |
Metabolic acidosis with a base deficit of > 8 mEq/L or plasma bicarbonate < 15 mmol/L |
Plasma lactate ≥ 5 mmol/L |
Respiratory distress |
Blood or plasma glucose < 40 mg/dL |
Haemoglobin ≤ 5 g/dL or haematocrit ≤ 15%, |
Haemoglobinuria |
Serum creatinine > 3 mg/dL or blood urea > 20 mmol/L |
Plasma or serum bilirubin > 3 mg/dL |
Clinical or radiographic evidence of pulmonary edema |
Significant abnormal bleeding |
Capillary refill ≥ 3 s or systolic blood pressure < 50 mmHg |