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Table 3 The test statistics and the p-values of MAX4 and the allelic test procedures for the 17 SNPs reported in Additional file 2: Table S1 using the three approaches: the parametric bootstrap (boot), the bivariate normal approach (bvn) and the asymptotic approach (asy) for the case of the MAX4 procedure

From: Genome-wide association testing in malaria studies in the presence of overdominance

SNPs

\(P-values\) using different Methods

Statistic

MAXboot

MAXbvn

MAXasym

Alle-statistic

AllelicP-value

Model

rs380390

5.11

1.0E−06

2.0E−06

8.6E−07

30.14

4.0E−08

Additive

rs1329428

4.92

7.5E−04

4.0E−06

2.2E−06

23.34

1.4E−06

Recessive

rs1447295

4.08

9.5E−05

1.0E−04

1.1E−04

16.64

4.5E−05

Additive

rs698267

4.46

1.7E−05

2.1E−05

2.2E−05

19.70

9.0E−06

Additive

rs7837688

4.69

5.0E−06

7.0E−06

6.7E−06

22.36

2.3E−06

Additive

rs10510126

4.99

2.2E-16

2.0E−06

1.4E−06

22.95

1.7E−06

Recessive

rs12505080

4.15

8.2E−05

8.9E−05

8.5E−05

0.96

3.3E−01

Dominant

rs17157903

4.72

2.0E−06

9.0E−06

5.8E−06

11.68

6.3E−04

Heterosis

rs1219648

4.77

6.0E−06

1.0E−05

5.0E−06

23.45

1.3E−06

Additive

rs7696175

4.48

2.0E−05

3.3E−05

2.0E−05

0.30

5.8E−01

Heterosis

rs2420946

4.75

6.0E−06

8.0E−06

5.3E−06

23.20

1.5E−06

Additive

rs2820037

5.28

2.2E-16

2.2E-16

3.2E−07

16.12

5.9E−05

Heterosis

rs6997709

4.46

2.2E−05

3.3E−05

2.1E−05

20.00

7.7E−06

Additive

rs7961152

19.96

7.9E−06

1.8E−05

2.0E−05

16.12

5.9E−05

Additive

rs11110912

4.65

8.0E−06

1.1E−05

8.1E−06

19.48

1.0E−05

Recessive

rs1937506

4.43

2.4E−05

2.4E−05

2.4E−05

19.55

9.8E−06

Additive

rs2398162

4.91

1.0E−06

3.0E−06

2.4E−06

20.41

6.2E−06

Recessive

  1. The underlying genetic models have been predicted using the MAX4 test procedure