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Table 2 Diagnostic performance of CareStartâ„¢ G6PD biosensor at different cut-off points

From: Prevalence of G6PD deficiency and diagnostic accuracy of a G6PD point-of-care test among a population at risk of malaria in Myanmar

CareStartâ„¢ G6PD Biosensor

30% G6PD activity cut-off (0.77 U/gHb) (95% CI)

70% G6PD activity cut-off (1.81 U/gHb) (95% CI)

80% G6PD activity cut-off (2.06 U/gHb) (95% CI)

Spectrophotometry cut-off

1.89 U/gHb

4.41 U/gHb

5.04 U/gHb

AUC (95%CI)

0.82

0.76

0.74

 

(0.71–0.94)

(0.65–0.86)

(0.63–0.84)

Sensitivity

0.63 (0.38–0.84)

0.69 (0.50–0.84)

0.65 (0.47–0.80)

Specificity

0.95 (0.89–0.98)

0.75 (0.67–0.83)

0.70 (0.61–0.78)

PPV

0.57 (0.37–0.75)

0.24 (0.17–0.32)

0.19 (0.14–0.26)

NPV

0.96 (0.93–0.98)

0.96 (0.93–0.97)

0.95 (0.92–0.97)

Accuracy

0.92 (0.86–0.95)

0.75 (0.67–0.82)

0.69 (0.61–0.77)

Prevalence

10%

18%

20%

True positive

12/19

22/51

22/57

True negative

124/131

89/99

81/93

False positive

7/19

29/51

35/57

False negative

7/131

10/99

12/93

  1. The performance of G6PD biosensor was calculated at 30%, 70% and 80% G6PD activity cut-off