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Fig. 1 | Malaria Journal

Fig. 1

From: Perennial malaria chemoprevention with and without malaria vaccination to reduce malaria burden in young children: a modelling analysis

Fig. 1

Modelled intervention efficacies, intervention schedules, and simulated cohort populations. A Intervention efficacy of modelled SP. Simulations ran with an EIR of 32 infectious bites per person per annum (ibpa), 60% effective clinical treatment coverage, and 95% coverage of a single dose of PMC with SP. Reference points are smoothed estimates based on the averaged effect of four doses in children less than 15 months in Ghana 2005 trial [33, 34]. B Age schedules of PMC and RTS,S deployments. C Intervention efficacy of the modelled malaria vaccine RTS,S [29] at 100% coverage. Simulations ran with an EIR of 11 ibpa and 90% treatment coverage of clinical cases. Data points correspond to RTS,S Phase 3 trial data from the Kintampo trial site [13], obtained from [27]. D Schematic of birth cohorts (n = 12) in simulation setup, truncated at five of ten follow-up years. Colored points indicate events when individuals receive either PMC, RTS,S, or both interventions. The inset figure shows the transmission seasonality relative to birth month of each cohort

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