Fig. 4

Predicted impact on malaria case incidence of PMC schedule with and without RTS,S in children under the age of two years at high transmission intensity. A Clinical and severe case incidence per 1000 population per year by age in the absence of PMC or RTS,S (gray line) or with PMC at various schedules or RTS,S, at 80% coverage. The solid line shows median and shaded area shows 90% PI. B Number of cases averted per 1000 population per year by PMC-RTS,S scenario at 80% coverage for children 0–1 and 1–2 years and U2 (0–2 years). The bar shows median and the error bars show 90% PI (relative reductions: Additional file 1: Fig A1.2.8). C Impact on clinical and severe cases of PMC-RTS,S scenarios at varying coverage levels, with median number of cases averted per 1000 population per year on the primary, y-axis and PE on the secondary y-axis. Projections varying by levels of transmission shown in Additional file 1: Fig A1.2.9