Parameter | Description/unit | Geographic-agnostic | Geographic-specific |
---|---|---|---|
Geography | Malaria setting simulation corresponds to | Not specified | 20 States in Southern Nigeria |
Population | Simulated total population | 30,000 (closed) | 30,000 (closed) |
Birth cohorts | Number of population cohorts simulated from birth | 12 | 12 |
Stochastic realizations | Number of random seeds for each scenario and birth cohort | 5 | 5 |
Transmission intensity | annual EIR in infectious bites per person per annum (ibpa) | 1, 4, 8, 16, 32, 64, 128 | Derived from simulated relationship between EIR and PfPR U5; EIR then estimated from PfPR U5 by rapid diagnostic test per State from NDHS 2018 [38]) |
Transmission seasonality | Monthly EIR | Taken from [36], aggregated per State. | |
Clinical treatment coverage | % of clinical episodes effectively treated | 60 | Obtained from NDHS 2018 for each State [38] |
Severe treatment coverage | % of severe episodes effectively treated | 80 | 80 |
PMC coverage | % of population U2 receiving PMC doses at target ages per dose at random | 80 | Target: 80, operational: informed by EPI coverage in Southern Nigeria for each State (NDHS 2018 [38]) |
PMC dosing schedule | Months of age at which child receives PMC | PMC-3: 2.5, 3.5, 9 PMC-4: 2.5, 3.5, 9, 12 PMC-5: 2.5, 3.5, 9, 12, 15 PMC-6: 2.5, 3.5, 6, 9, 12, 15 PMC-7: 2.5, 3.5, 6, 9, 12, 15, 18 | PMC-3: 2.5, 3.5, 9 PMC-5: 2.5, 3.5, 9, 12, 15 PMC-7: 2.5, 3.5, 6, 9, 12, 15, 18 |
RTS,S coverage primary sequence | % of children receiving all 3 primary doses (combined at 9 months of age) | 80 | target: 0.8, operational: informed by EPI coverage for each State (NDHS 2018 [38]) |
RTS,S booster coverage | % of children receiving booster out of those received full primary sequence | 80 | 80 |
RTS,S schedule | Months of age at which child receives RTS,S dose | 6, 7.5, 9 (initial 3-dose priming sequence) + 24 (booster) | 6, 7.5, 9 (initial 3-dose priming sequence) + 24 (booster) |