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Table 2 Fundus fluorescein angiogram findings in cerebral malaria

From: Retinal imaging technologies in cerebral malaria: a systematic review

Study author

Year

Adult/Child

UM/SM/CM

No. patients (No. CMa)

No. any abnormality (%)

No. CNP (%)

No. IVFDs (%)

No. FL (%)

Total

Macula

Periphery

LFL

PL

Vessel leak

Disc Leak

Post-capillary venules

Larger Venules

MacCormickb

2022

Child

CM

260

–

–

 > 88%

 > 57%

15% c

18%

32%

 > 29%

44%

-

Barrerab

2018

Child

CM

260

–

–

–

–

98% d

–

–

–

-

-

MacCormickb

2015

Child

Not stated

(MR +)

264 (259)

264 (100)

100%

100%

95%

60–90% d,e

12% e

30% e

50% e

60% e

80% e

Beareb

2008

Child

CM

34

28 (82)

26 (76)

19 (56)

22 (65)

9 (26)

15 (44)

Hero

1997

Child

CM / SM

12 (11)

5 (42)

2 (17)

–

–

–

0 (0)

0 (0)

0 (0)

2 (17)

Davis

1992

Adult

CM

5

3 (60)

3 (60)

–

–

–

3 (60)

SM

13

4 (31)

3 (23)

–

–

–

2 (15)

  1. UM uncomplicated malaria, SM severe malaria, CM cerebral malaria, CNP capillary non-perfusion, IVFD intravascular filling defect, LFL large focal leak, PL, punctate leak, MR+ malarial retinopathy positive, – not recorded
  2. a where relevant
  3. b datasets may contain same patients
  4. c arteriolar
  5. d multiple vessels analysed, highest figures quoted (post capillary venules)
  6. e approximate figures