Table 4 Treatment outcome among children (PP) from southwest Nigeria with acute uncomplicated malaria treated with artemether–lumefantrine or pyronaridine–artesunate in different age groups
Treatment outcome | Drug group | Total | ρ-value | |
|---|---|---|---|---|
AL | PA | |||
Age < 12 months (N = 8) | 3 | 5 | 8 | |
ACPR | 2 (66.7) | 5 (100) | 7 (87.5) | 0.375 |
LCF | 1 (33.3) | 0 (0) | 1 (12.5) | |
Age < 60 months (N = 47) | N = 22 | N = 25 | N = 47 | |
ACPR | 14 (63.6) | 24 (96.0) | 38 (80.9) | 0.008 |
LPF | 4 (18.2) | 1 (4.0) | 5 (10.68) | |
LCF | 4 (18.2) | 0 (0) | 4 (8.5) | |
Age ≥ 60 months (N = 118) | N = 61 | N = 57 | N = 118 | |
Cured (ACPR) | 45 (73.8) | 52 (91.2) | 97 (82.2) | 0.016 |
Failed (LCF + LPF) | 16 (26.2) | 5 (6.1) | 21 (17.8) | |
ACPR | 45 (73.8) | 52 (91.2) | 97 (82.2) | 0.046 |
LPF | 13 (21.3) | 4 (7.0) | 17 (14.4) | |
LCF | 3 (4.9) | 1 (1.8) | 4 (3.4) | |
Total PP (N = 165) | 83 | 82 | 165 | |
ACPR | 59/83 (71.1) | 76/82 (92.7) | 135/165 (81.8) | 0.001 |
LPF | 17/83 (20.5) | 5/82 (6.1) | 22 (13.3) | |
LCF | 7/83 (8.4) | 1/82 (1.2) | 8 (4.8) | |
Cured (ACPR) | 59/83 (71.1) | 76/82 (92.7) | 135/165 (81.8) | < 0.0001 |
Failed (LCF + LPF) | 24/83 (28.9) | 6/82 (7.3) | 30/165 (18.2) | |
PP-PCR corrected | N = 67 | N = 78 | N = 145 | 0.04 |
Cure rate—D28 | 59 (88.1) | 76 (97.4) | 135 (93.1) | |
Recrudescence | 8 (11.9) | 2 (02.6) | 10 (6.9) | |