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Table 1 Anti-malarial activity of isoliensinine against asexuals of P. falciparum laboratory adapted reference clones determined by a malaria SYBR Green I assay

From: Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates

Antimalarial

Mean IC50 ± S.D (µM)a

Resistance Index (RI)e

PfD6b

PfDd2c

PfF32-ART5d

RI1

RI2

Artesunate

0.003 ± 0.0014

0.002 ± 0.0007

0.004 ± 0.0000

0.667

1.333

Dihydroartemisinin

0.002 ± 0.0000

0.005 ± 0.0000

0.004 ± 0.0006

2.500

2.000

Chloroquine

0.022 ± 0.0007

0.325 ± 0.0321

0.016 ± 0.0005

14.773

0.727

Mefloquine

0.017 ± 0.0049

0.113 ± 0.0014

0.029 ± 0.0027

6.650

1.706

Atovaquone

0.004 ± 0.0003

0.002 ± 0.0007

0.004 ± 0.0004

0.500

1.000

Artemether

0.004 ± 0.0014

0.004 ± 0.0014

0.007 ± 0.0021

1.000

1.75

Piperaquine

0.024 ± 0.0064

0.054 ± 0.0424

0.050 ± 0.0104

2.25

2.083

Amodiaquine

0.008 ± 0.0021

0.008 ± 0.0021

0.007 ± 0.0017

1.000

0.875

Isoliensinine

2.17 ± 0.2775

2.22 ± 0.4097

2.39 ± 0.2001

1.023

1.101

  1. aAnti-malarial activity performed for three independent biological replicates
  2. bPfD6: Chloroquine sensitive, Mefloquine resistant clone
  3. cPfDd2: Chloroquine, Mefloquine, Quinine, Pyrimethamine resistant; Chloroquine sensitive clone
  4. dPfF32-ART5: Artemisinin resistant clone
  5. eRI1 = IC50 Dd2/D6; RI2 = IC50 F32-ART5/D6
  6. S.D—standard deviation