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  1. In Uganda, like in many other countries traditionally viewed as harbouring very high malaria transmission, the norm has been to recommend that febrile episodes are diagnosed as malaria. In this study, the poli...

    Authors: Joan Nankabirwa, Dejan Zurovac, Julius N Njogu, John B Rwakimari, Helen Counihan, Robert W Snow and James K Tibenderana

    Citation: Malaria Journal 2009 8:66

    Content type: Research

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  2. The efficacy of artemisinin-based combination therapy has already been demonstrated in a number of studies all over the world, and some of them can be regarded as comparably effective. Ease of administration o...

    Authors: Issaka Sagara, Stephen Rulisa, Wilfred Mbacham, Ishag Adam, Kourane Sissoko, Hamma Maiga, Oumar B Traore, Niawanlou Dara, Yahia T Dicko, Alassane Dicko, Abdoulaye Djimdé, F Herwig Jansen and Ogobara K Doumbo

    Citation: Malaria Journal 2009 8:63

    Content type: Research

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  3. Ideally larval control activities should be targeted at sites that generate the most adult vectors, thereby reducing operational costs. Despite the plethora of potential mosquito breeding sites found in the fl...

    Authors: Ulrike Fillinger, Heleen Sombroek, Silas Majambere, Emiel van Loon, Willem Takken and Steven W Lindsay

    Citation: Malaria Journal 2009 8:62

    Content type: Research

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  4. The risk of Plasmodium falciparum infection is variable over space and time and this variability is related to environmental variability. Environmental factors affect the biological cycle of both vector and paras...

    Authors: Jean Gaudart, Ousmane Touré, Nadine Dessay, A lassane Dicko, Stéphane Ranque, Loic Forest, Jacques Demongeot and Ogobara K Doumbo

    Citation: Malaria Journal 2009 8:61

    Content type: Research

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  5. Anopheles (Kerteszia) cruzii was the most important vector of human malaria in southern Brazil between 1930–1960. Nowadays it is still considered an important Plasmodium spp. vector in southern and south-eastern ...

    Authors: Luísa DP Rona, Carlos J Carvalho-Pinto, Carla Gentile, Edmundo C Grisard and Alexandre A Peixoto

    Citation: Malaria Journal 2009 8:60

    Content type: Research

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  6. In response to chloroquine (CQ) resistance, the policy for the first-line treatment of uncomplicated malaria in the Democratic Republic of East Timor (DRET) was changed in early 2000. The combination of sulpha...

    Authors: Afonso de Almeida, Ana Paula Arez, Pedro VL Cravo and Virgílio E do Rosário

    Citation: Malaria Journal 2009 8:59

    Content type: Research

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  7. Artemisinin-based combination therapy (ACT) is recommended as a means of prolonging the effectiveness of first-line malaria treatment regimens. Different brands of mefloquine (MQ) have been reported to be non-...

    Authors: Julie Gutman, Michael Green, Salomon Durand, Ofelia Villalva Rojas, Babita Ganguly, Wilmer Marquiño Quezada, Gregory C Utz, Laurence Slutsker, Trenton K Ruebush II and David J Bacon

    Citation: Malaria Journal 2009 8:58

    Content type: Research

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  8. Historically, environmental management has brought important achievements in malaria control and overall improvements of health conditions. Currently, however, implementation is often considered not to be cost...

    Authors: Marcia C Castro, Atsuko Tsuruta, Shogo Kanamori, Khadija Kannady and Sixbert Mkude

    Citation: Malaria Journal 2009 8:57

    Content type: Research

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  9. For companies operating in malaria endemic countries, malaria represents a substantial risk to workers and their dependants, and can lead to significantly reduced worker productivity. This study provides an ov...

    Authors: Bianca Pluess, Ivo Mueller, Damien Levi, Graham King, Thomas A Smith and Christian Lengeler

    Citation: Malaria Journal 2009 8:56

    Content type: Research

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  10. There are increasing reports of severe clinical cases exclusively associated with Plasmodium vivax infections. Notably, this severity has been recently suggested to be associated with chloroquine resistance.

    Authors: Carmen Fernández-Becerra, Maria Jesús Pinazo, Ana González, Pedro L Alonso, Hernando A del Portillo and Joaquim Gascón

    Citation: Malaria Journal 2009 8:55

    Content type: Research

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  11. To date all efforts to develop a malaria vaccine have failed, reflecting the still fragmentary knowledge about protective mechanisms against malaria. In order to evaluate if vaccination changes responses of th...

    Authors: Jürgen Krücken, Denis Delić, Heike Pauen, Anna Wojtalla, Manal El-Khadragy, Mohamed A Dkhil, Horst Mossmann and Frank Wunderlich

    Citation: Malaria Journal 2009 8:54

    Content type: Research

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  12. GIMAP (GTPase of the immunity-associated protein family) proteins are a family of putative GTPases believed to be regulators of cell death in lymphomyeloid cells. GIMAP1 was the first reported member of this g...

    Authors: Amy Saunders, Tracey Lamb, John Pascall, Amanda Hutchings, Carine Dion, Christine Carter, Lucy Hepburn, Jean Langhorne and Geoffrey W Butcher

    Citation: Malaria Journal 2009 8:53

    Content type: Research

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  13. Artemisinin combination therapy (ACT) has been widely adopted as first-line treatment for uncomplicated falciparum malaria. In Uganda, amodiaquine plus artesunate (AQ+AS), is the alternative first-line regimen...

    Authors: Muhammad Ntale, Celestino Obua, Jackson Mukonzo, Margarita Mahindi, Lars L Gustafsson, Olof Beck and Jasper W Ogwal-Okeng

    Citation: Malaria Journal 2009 8:52

    Content type: Methodology

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  14. While insecticide-treated nets (ITNs) are a recognized effective method for preventing malaria, there has been an extensive debate in recent years about the best large-scale implementation strategy. Implementa...

    Authors: Joshua O Yukich, Mehari Zerom, Tewolde Ghebremeskel, Fabrizio Tediosi and Christian Lengeler

    Citation: Malaria Journal 2009 8:51

    Content type: Research

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  15. Toll-like receptors (TLR) and related downstream signaling pathways of innate immunity have been implicated in the pathogenesis of Plasmodium falciparum malaria. Because of their potential role in malaria pathoge...

    Authors: Jennifer A Greene, Ann M Moormann, John Vulule, Moses J Bockarie, Peter A Zimmerman and James W Kazura

    Citation: Malaria Journal 2009 8:50

    Content type: Research

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  16. Zambia has taken lead in implementing integrated malaria control so as to attain the National Health Strategic Plan goal of "reducing malaria incidence by 75% and under-five mortality due to malaria by 20% by ...

    Authors: Pascalina Chanda, Busiku Hamainza, Susan Mulenga, Victor Chalwe, Charles Msiska and Elizabeth Chizema-Kawesha

    Citation: Malaria Journal 2009 8:49

    Content type: Research

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  17. Artesunate (AS) plus amodiaquine (AQ) is one artemisinin-based combination (ACT) recommended by the WHO for treating Plasmodium falciparum malaria. Fixed-dose AS/AQ is new, but its safety and efficacy are hithert...

    Authors: Sodiomon B Sirima, Alfred B Tiono, Adama Gansané, Amidou Diarra, Amidou Ouédraogo, Amadou T Konaté, Jean René Kiechel, Caroline C Morgan, Piero L Olliaro and Walter RJ Taylor

    Citation: Malaria Journal 2009 8:48

    Content type: Research

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  18. Strains of Plasmodium falciparum genetically resistant to chloroquine (CQ) due to the presence of pfcrt 76T appear to have been recently introduced to the island of Madagascar. The prevalence of such resistant ge...

    Authors: Jonathan J Juliano, Milijaona Randrianarivelojosia, Benjamin Ramarosandratana, Frédéric Ariey, Victor Mwapasa and Steven R Meshnick

    Citation: Malaria Journal 2009 8:47

    Content type: Methodology

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  19. Despite investments in providing free government health services in Uganda, many caretakers still seek treatment from the drug shops/private clinics. The study aimed to assess determinants for use of governmen...

    Authors: Elizeus Rutebemberwa, George Pariyo, Stefan Peterson, Goran Tomson and Karin Kallander

    Citation: Malaria Journal 2009 8:45

    Content type: Research

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  20. During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction with plasmodium DNA or another malaria motif not yet identified. Although TLR9 activation by malaria parasites is well repor...

    Authors: Susana Campino, Julian Forton, Sarah Auburn, Andrew Fry, Mahamadou Diakite, Anna Richardson, Jeremy Hull, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Malcolm E Molyneux, Terrie E Taylor, Kirk Rockett, Taane G Clark and Dominic P Kwiatkowski

    Citation: Malaria Journal 2009 8:44

    Content type: Research

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  21. A SNP at position 131, in the FcγRIIa gene, affects the binding of the different IgG subclasses and may influence the clinical variation seen in patients with falciparum malaria. This study confirms and extend...

    Authors: Amre Nasr, Nnaemeka C Iriemenam, Hayder A Giha, Halima A Balogun, Robin F Anders, Marita Troye-Blomberg, Gehad ElGhazali and Klavs Berzins

    Citation: Malaria Journal 2009 8:43

    Content type: Research

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  22. Following its recent re-emergence, malaria has gained renewed attention as a serious infectious disease in Korea. Three species of the Hyrcanusgroup, Anopheles lesteri, Anopheles sinensis and Anopheles pullus, ha...

    Authors: Deepak Joshi, Wej Choochote, Mi-Hyun Park, Jung-Yeon Kim, Tong-Soo Kim, Wannapa Suwonkerd and Gi-Sik Min

    Citation: Malaria Journal 2009 8:42

    Content type: Research

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  23. When diagnosed by standard light microscopy (LM), malaria prevalence can vary significantly between sites, even at local scale, and mixed species infections are consistently less common than expect in areas co...

    Authors: Ivo Mueller, Simone Widmer, Daniela Michel, Seri Maraga, David T McNamara, Benson Kiniboro, Albert Sie, Thomas A Smith and Peter A Zimmerman

    Citation: Malaria Journal 2009 8:41

    Content type: Research

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  24. Reliable molecular typing tools are required for a better understanding of the molecular epidemiology of Plasmodium vivax. The genes msp3a and msp1 _block5 are highly polymorphic and have been used as markers in ...

    Authors: Vincent Véron, Eric Legrand, Joséphine Yrinesi, Béatrice Volney, Stéphane Simon and Bernard Carme

    Citation: Malaria Journal 2009 8:40

    Content type: Research

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  25. Malaria remains a major public health problem especially in sub-Saharan Africa. Despite the efforts exerted to provide effective anti-malarial drugs, still some communities suffer from getting access to these ...

    Authors: Khalid A Elmardi, Elfatih M Malik, Tarig Abdelgadir, Salah H Ali, Abdalla H Elsyed, Mahmoud A Mudather, Asma H Elhassan and Ishag Adam

    Citation: Malaria Journal 2009 8:39

    Content type: Research

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  26. Malaria is a global health emergency, and yet our understanding of the energy metabolism of the principle causative agent of this devastating disease, Plasmodium falciparum, remains rather basic. Glucose was show...

    Authors: Lu-Yun Lian, Mohammed Al-Helal, Abd Majid Roslaini, Nicholas Fisher, Patrick G Bray, Stephen A Ward and Giancarlo A Biagini

    Citation: Malaria Journal 2009 8:38

    Content type: Research

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  27. A study carried out in 2003–2005 in Southern Benin showed a day-28 sulphadoxine-pyrimethamine (SP) monotherapy failure rate greater than 40%, while for SP combined with artesunate (SP-AS) the failure rate was ...

    Authors: Alain Nahum, Annette Erhart, Daniel Ahounou, Désiré Bonou, Chantal Van Overmeir, Joris Menten, Martin Akogbeto, Marc Coosemans, Achille Massougbodji and Umberto D'Alessandro

    Citation: Malaria Journal 2009 8:37

    Content type: Research

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  28. Cerebral malaria (CM) is associated with high mortality and morbidity caused by a high rate of transient or persistent neurological sequelae. Studies on immunomodulatory and neuroprotective drugs as ancillary ...

    Authors: Peter Lackner, Andrea Part, Christoph Burger, Anelia Dietmann, Gregor Broessner, Raimund Helbok, Markus Reindl, Erich Schmutzhard and Ronny Beer

    Citation: Malaria Journal 2009 8:36

    Content type: Research

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  29. Whilst a large number of malaria antigens are being tested as candidate malaria vaccines, a major barrier to the development of an effective vaccine is the lack of a suitable human adjuvant capable of inducing...

    Authors: Gustavo Bracho, Caridad Zayas, Lina Wang, Ross Coppel, Oliver Pérez and Nikolai Petrovsky

    Citation: Malaria Journal 2009 8:35

    Content type: Research

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  30. To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria.

    Authors: Mamadou Tekete, Abdoulaye A Djimde, Abdoul H Beavogui, Hamma Maiga, Issaka Sagara, Bakary Fofana, Dinkorma Ouologuem, Souleymane Dama, Aminatou Kone, Demba Dembele, Mamadou Wele, Alassane Dicko and Ogobara K Doumbo

    Citation: Malaria Journal 2009 8:34

    Content type: Research

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  31. New artemisinin combination therapies pose difficulties of implementation in developing and tropical settings because they have a short shelf-life (two years) relative to the medicines they replace. This limit...

    Authors: Roger Bate, Richard Tren, Kimberly Hess and Amir Attaran

    Citation: Malaria Journal 2009 8:33

    Content type: Research

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  32. Over the last years, significant progress has been made in the comprehension of the molecular mechanism of malaria resistance to drugs. Together with in vivo tests, the molecular monitoring is now part of the sur...

    Authors: Maman Laminou Ibrahim, Nicolas Steenkeste, Nimol Khim, Hadiza Hassane Adam, Lassana Konaté, Jean-Yves Coppée, Fredéric Ariey and Jean-Bernard Duchemin

    Citation: Malaria Journal 2009 8:32

    Content type: Research

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  33. Artemisinin combination therapy (ACT) is now the recommended first-line treatment for falciparum malaria throughout the world. Initiatives to eliminate malaria are critically dependent on its efficacy. There i...

    Authors: Richard J Maude, Wirichada Pontavornpinyo, Sompob Saralamba, Ricardo Aguas, Shunmay Yeung, Arjen M Dondorp, Nicholas PJ Day, Nicholas J White and Lisa J White

    Citation: Malaria Journal 2009 8:31

    Content type: Review

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  34. Current use of treated mosquito nets for the prevention of malaria falls short of what is expected in sub-Saharan Africa (SSA), though research within the continent has indicated that the use of these commodit...

    Authors: Bamgboye M Afolabi, Olayemi T Sofola, Bayo S Fatunmbi, William Komakech, Festus Okoh, Oladele Saliu, Peju Otsemobor, Olusola B Oresanya, Chioma N Amajoh, David Fasiku and Inuwa Jalingo

    Citation: Malaria Journal 2009 8:30

    Content type: Research

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  35. The potential contribution of knowledge, attitudes and practices (KAP) studies to malaria research and control has not received much attention in most southern African countries. This study investigated the lo...

    Authors: Khumbulani W Hlongwana, Musawenkosi LH Mabaso, Simon Kunene, Dayanandan Govender and Rajendra Maharaj

    Citation: Malaria Journal 2009 8:29

    Content type: Research

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  36. Plasmodium falciparum resistance to drugs remains a major public health issue in Niger. The therapeutic failure index for chloroquine and sulphadoxine-pyrimethamine are, respectively 20% and 21.9%. In December 20...

    Authors: Maman Laminou Ibrahim, Nimol Khim, Hassane Hadiza Adam, Frédéric Ariey and Jean-Bernard Duchemin

    Citation: Malaria Journal 2009 8:28

    Content type: Research

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  37. Knowledge of geography is integral to the study of insect-borne infectious disease such as malaria. This study was designed to evaluate whether geographic parameters are associated with malarial infection in t...

    Authors: Ward P Myers, Andrea P Myers, Janet Cox-Singh, Hui C Lau, Benny Mokuai and Richard Malley

    Citation: Malaria Journal 2009 8:27

    Content type: Research

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  38. Herbal extracts of Andrographis paniculata (AP) and Hedyotis corymbosa (HC) are known as hepato-protective and fever-reducing drugs since ancient time and they have been used regularly by the people in the south ...

    Authors: Kirti Mishra, Aditya P Dash, Bijay K Swain and Nrisingha Dey

    Citation: Malaria Journal 2009 8:26

    Content type: Research

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  39. The use of most anti-malarial medications is restricted during pregnancy, but two doses of sulphadoxine-pyrimethamine are recommended after the first trimester as intermittent preventive treatment in pregnancy...

    Authors: Loretta Brabin, Elizabeth Stokes, Isatou Dumbaya and Stephen Owens

    Citation: Malaria Journal 2009 8:25

    Content type: Research

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  40. Malaria in pregnancy (MiP) is inadequately researched in India, and the burden is probably much higher than current estimates suggest. This paper models the burden of MiP and associated foetal losses and mater...

    Authors: Nadia Diamond-Smith, Neeru Singh, RK Das Gupta, Aditya Dash, Krongthong Thimasarn, Oona MR Campbell and Daniel Chandramohan

    Citation: Malaria Journal 2009 8:24

    Content type: Research

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  41. Recent years have seen publication of a considerable number of clinical trials of preventive interventions against clinical malaria in children. There has been variability in the specification of end-points, c...

    Authors: Vasee S Moorthy, Zarifah Reed and Peter G Smith

    Citation: Malaria Journal 2009 8:23

    Content type: Review

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  42. There is little existing knowledge about actual quality of drugs provided by different providers in Nigeria and in many sub-Saharan African countries. Such information is important for improving malaria treatm...

    Authors: Obinna Onwujekwe, Harparkash Kaur, Nkem Dike, Elvis Shu, Benjamin Uzochukwu, Kara Hanson, Viola Okoye and Paul Okonkwo

    Citation: Malaria Journal 2009 8:22

    Content type: Research

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  43. Ethiopia plans to increase its electricity power supply by five-fold over the next five years to fulfill the needs of its people and support the economic growth based on large hydropower dams. Building large d...

    Authors: Delenasaw Yewhalaw, Worku Legesse, Wim Van Bortel, Solomon Gebre-Selassie, Helmut Kloos, Luc Duchateau and Niko Speybroeck

    Citation: Malaria Journal 2009 8:21

    Content type: Research

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  44. In Iran, co-infections of Plasmodium vivax and Plasmodium falciparum are common and P. vivax infections are often exposed to sulphadoxine-pyrimethamine (SP). In the present study, the frequency distribution of mu...

    Authors: Sedigheh Zakeri, Shadi Rabiei Motmaen, Mandana Afsharpad and Navid Dinparast Djadid

    Citation: Malaria Journal 2009 8:20

    Content type: Research

    Published on:

  45. Plasmodium falciparum malaria is a serious tropical disease that causes more than one million deaths each year, most of them in Africa. It is transmitted by a range of Anopheles mosquitoes and the risk of disease...

    Authors: Louise A Kelly-Hope and F Ellis McKenzie

    Citation: Malaria Journal 2009 8:19

    Content type: Review

    Published on:

  46. Malaria is one of the most important tropical diseases that affects people globally. The influence of environmental conditions in the patterns of temporal distribution of malaria vectors and the disease has be...

    Authors: María J Dantur Juri, Mario Zaidenberg, Guillermo L Claps, Mirta Santana and Walter R Almirón

    Citation: Malaria Journal 2009 8:18

    Content type: Research

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  47. Malaria epidemics cause substantial morbidity and mortality in highland areas of Africa. The costs of detecting and controlling these epidemics have not been explored adequately in the past. This study present...

    Authors: Dirk H Mueller, Tarekegn A Abeku, Michael Okia, Beth Rapuoda and Jonathan Cox

    Citation: Malaria Journal 2009 8:17

    Content type: Research

    Published on:

  48. While the protective effects of sickle cell trait (HbAS) against severe malaria and the resulting survival advantage are well known, the impact on the physical development in young children remains unclear. Th...

    Authors: Benno Kreuels, Stephan Ehrhardt, Christina Kreuzberg, Samuel Adjei, Robin Kobbe, Gerd D Burchard, Christa Ehmen, Matilda Ayim, Ohene Adjei and Jürgen May

    Citation: Malaria Journal 2009 8:16

    Content type: Research

    Published on:

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