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  1. New antimalarial regimens, including artemisinin-based combination therapies (ACTs), have been adopted widely as first-line treatment for uncomplicated malaria. Although these drugs appear to be safe and well-...

    Authors: Sarah G Staedke, Prasanna Jagannathan, Adoke Yeka, Hasifa Bukirwa, Kristin Banek, Catherine Maiteki-Sebuguzi, Tamara D Clark, Bridget Nzarubara, Denise Njama-Meya, Arthur Mpimbaza, Philip J Rosenthal, Moses R Kamya, Fred Wabwire-Mangen, Grant Dorsey and Ambrose O Talisuna

    Citation: Malaria Journal 2008 7:107

    Content type: Case study

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  2. Combination antimalarial therapy is recommended for the treatment of uncomplicated falciparum malaria in Africa; however, some concerns about the safety and tolerability of new regimens remain. This study compare...

    Authors: Catherine Maiteki-Sebuguzi, Prasanna Jagannathan, Vincent M Yau, Tamara D Clark, Denise Njama-Meya, Bridget Nzarubara, Ambrose O Talisuna, Moses R Kamya, Philip J Rosenthal, Grant Dorsey and Sarah G Staedke

    Citation: Malaria Journal 2008 7:106

    Content type: Research

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  3. Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of parasites in the placenta with severe clinica...

    Authors: Mafalda Resende, Morten A Nielsen, Madeleine Dahlbäck, Sisse B Ditlev, Pernille Andersen, Adam F Sander, Nicaise T Ndam, Thor G Theander and Ali Salanti

    Citation: Malaria Journal 2008 7:104

    Content type: Research

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  4. Knowledge on insecticide resistance in target species is a basic requirement to guide insecticide use in malaria control programmes. Malaria transmission in the Mekong region is mainly concentrated in forested...

    Authors: Wim Van Bortel, Ho Dinh Trung, Le Khanh Thuan, Tho Sochantha, Duong Socheat, Chalao Sumrandee, Visut Baimai, Kalouna Keokenchanh, Phompida Samlane, Patricia Roelants, Leen Denis, Katrijn Verhaeghen, Valerie Obsomer and Marc Coosemans

    Citation: Malaria Journal 2008 7:102

    Content type: Research

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  5. The insertion of parasite antigens into the host erythrocyte membrane and the structure and distribution of Plasmodium falciparum adhesion receptors on that membrane are poorly understood. Laser scanning confocal...

    Authors: Dominique Bengtsson, Kordai M Sowa, Ali Salanti, Anja TR Jensen, Louise Joergensen, Louise Turner, Thor G Theander and David E Arnot

    Citation: Malaria Journal 2008 7:101

    Content type: Research

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  6. Malaria is an important public-health problem in the archipelago of Vanuatu and climate has been hypothesized as important influence on transmission risk. Beginning in 1988, a major intervention using insectic...

    Authors: Luis Fernando Chaves, Akira Kaneko, George Taleo, Mercedes Pascual and Mark L Wilson

    Citation: Malaria Journal 2008 7:100

    Content type: Research

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  7. Clinical case treatment of malaria infections where Plasmodium falciparum and Plasmodium vivax are sympatric has achieved effective reductions in P. falciparum prevalence and incidence rates, but has been less su...

    Authors: Waraphon Phimpraphi, Richard E Paul, Surapon Yimsamran, Supalarp Puangsa-art, Nipon Thanyavanich, Wanchai Maneeboonyang, Sutthiporn Prommongkol, Samarn Sornklom, Wutthichai Chaimungkun, Irwin F Chavez, Herve Blanc, Sornchai Looareesuwan, Anavaj Sakuntabhai and Pratap Singhasivanon

    Citation: Malaria Journal 2008 7:99

    Content type: Research

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  8. Tanzania has a well-developed network of commercial ITN retailers. In 2004, the government introduced a voucher subsidy for pregnant women and, in mid 2005, helped distribute free nets to under-fives in small ...

    Authors: Rashid A Khatib, Gerry F Killeen, Salim MK Abdulla, Elizeus Kahigwa, Peter D McElroy, Rene PM Gerrets, Hassan Mshinda, Alex Mwita and S Patrick Kachur

    Citation: Malaria Journal 2008 7:98

    Content type: Research

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  9. Plasmodium falciparum infection is known to be associated with a spectrum of systemic complications ranging from mild and self-limiting to life-threatening. This case report illustrates a patient who had a protra...

    Authors: Pratibha Seshadri, Anand Vimal Dev, Surekha Viggeswarpu, Sowmya Sathyendra and John Victor Peter

    Citation: Malaria Journal 2008 7:97

    Content type: Case report

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  10. There is concern about an increasing infiltration of markets by substandard and fake medications against life-threatening diseases in developing countries. This is particularly worrying with regard to the incr...

    Authors: Maike Tipke, Salou Diallo, Boubacar Coulibaly, Dominic Störzinger, Torsten Hoppe-Tichy, Ali Sie and Olaf Müller

    Citation: Malaria Journal 2008 7:95

    Content type: Research

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  11. Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidati...

    Authors: Wesley W Sharrock, Rossarin Suwanarusk, Usa Lek-Uthai, Michael D Edstein, Varakorn Kosaisavee, Thomas Travers, Anchalee Jaidee, Kanlaya Sriprawat, Ric N Price, François Nosten and Bruce Russell

    Citation: Malaria Journal 2008 7:94

    Content type: Research

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  12. Several of the intended Plasmodium falciparum vaccine candidate antigens are highly polymorphic and could render a vaccine ineffective if their antigenic sites were not represented in the vaccine. In this study, ...

    Authors: Stella M Chenet, OraLee H Branch, Ananias A Escalante, Carmen M Lucas and David J Bacon

    Citation: Malaria Journal 2008 7:93

    Content type: Research

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  13. Pyrethroid insecticide-treated mosquito nets are massively being scaled-up for malaria prevention particularly in children under five years of age and pregnant mothers in sub-Saharan Africa. However, there is ...

    Authors: Rubaihayo John, Tukesiga Ephraim and Abaasa Andrew

    Citation: Malaria Journal 2008 7:92

    Content type: Research

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  14. Antipyretic drugs are widely used in children with fever, though there is a controversy about the benefit of reducing fever in children with malaria. In order to assess the effect of ibuprofen on fever compare...

    Authors: Pierre-Blaise Matsiégui, Michel A Missinou, Magdalena Necek, Elie Mavoungou, Saadou Issifou, Bertrand Lell and Peter G Kremsner

    Citation: Malaria Journal 2008 7:91

    Content type: Research

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  15. Rapid and correct diagnosis of malaria is considered an important strategy in the control of the disease. However, it remains to be determined how well these tests can perform in those who harbour the parasite...

    Authors: Samuel Wanji, Helen K Kimbi, Joan E Eyong, Nicholas Tendongfor and Judith L Ndamukong

    Citation: Malaria Journal 2008 7:89

    Content type: Research

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  16. In Zambia the first-line treatment for uncomplicated malaria is artemisinin combination therapy (ACT), with artemether-lumefantrine currently being used. However, the antifolate regimen, sulphadoxine-pyrimetha...

    Authors: Mtawa AP Mkulama, Sandra Chishimba, Jay Sikalima, Petrica Rouse, Philip E Thuma and Sungano Mharakurwa

    Citation: Malaria Journal 2008 7:87

    Content type: Research

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  17. In order to assess the effectiveness of long-lasting insecticide-treated nets (LLINs) as a method for malaria control, there is a need to determine how high is the retention of bed nets, how they are utilized,...

    Authors: Saad El-Din Hussein Hassan, Elfatih M Malik, Somia I Okoued and Elsadig M Eltayeb

    Citation: Malaria Journal 2008 7:85

    Content type: Research

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  18. Plasmodium falciparum in a subset of patients can lead to cerebral malaria (CM), a major contributor to malaria-associated mortality. Despite treatment, CM mortality can be as high as 30%, while 10% of survivors ...

    Authors: Vidhan Jain, Henry B Armah, Jon E Tongren, Renée M Ned, Nana O Wilson, Sara Crawford, Pradeep K Joel, Mrigendra P Singh, Avinash C Nagpal, AP Dash, Venkatachalam Udhayakumar, Neeru Singh and Jonathan K Stiles

    Citation: Malaria Journal 2008 7:83

    Content type: Research

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  19. Two Plasmodium berghei ookinete micronemal proteins, circumsporozoite and TRAP related protein (CTRP) and secreted ookinete adhesive protein (SOAP) both interact with the basal lamina component laminin. Following...

    Authors: Adéla Nacer, Ann Underhill and Hilary Hurd

    Citation: Malaria Journal 2008 7:82

    Content type: Research

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  20. The relationship between malaria and obesity are largely unknown. This is partly due to the fact that malaria occurs mainly in tropical areas where, until recently, obesity was not prevalent. It now appears, h...

    Authors: Vincent Robert, Catherine Bourgouin, Delphine Depoix, Catherine Thouvenot, Marie-Noëlle Lombard and Philippe Grellier

    Citation: Malaria Journal 2008 7:81

    Content type: Research

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  21. The Atelier Paludisme (Malaria Workshop) is an international training course organized by the Institut Pasteur de Madagascar, which has been held annually for the past five years. The course was designed for both...

    Authors: Olivier Domarle, Milijaona Randrianarivelojosia, Jean-Bernard Duchemin, Vincent Robert and Frédéric Ariey

    Citation: Malaria Journal 2008 7:80

    Content type: Commentary

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  22. Intermittent preventive treatment (IPTp) is efficacious in reducing the adverse outcomes associated with pregnancy-associated malaria, however uptake of the recommended two doses is low in Tanzania, and little...

    Authors: Katherine Anders, Tanya Marchant, Pili Chambo, Pasiens Mapunda and Hugh Reyburn

    Citation: Malaria Journal 2008 7:79

    Content type: Research

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  23. The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified and measure...

    Authors: Sonja Schoepflin, Jutta Marfurt, Mary Goroti, Moses Baisor, Ivo Mueller and Ingrid Felger

    Citation: Malaria Journal 2008 7:78

    Content type: Research

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  24. Rainfall data have potential use for malaria prediction. However, the relationship between rainfall and the number of malaria cases is indirect and complex.

    Authors: Olivier JT Briët, Penelope Vounatsou, Dissanayake M Gunawardena, Gawrie NL Galappaththy and Priyanie H Amerasinghe

    Citation: Malaria Journal 2008 7:77

    Content type: Research

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  25. Malaria in Sri Lanka is unstable and fluctuates in intensity both spatially and temporally. Although the case counts are dwindling at present, given the past history of resurgence of outbreaks despite effectiv...

    Authors: Olivier JT Briët, Penelope Vounatsou, Dissanayake M Gunawardena, Gawrie NL Galappaththy and Priyanie H Amerasinghe

    Citation: Malaria Journal 2008 7:76

    Content type: Research

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  26. In the Global Strategy for Malaria Control, one of the basic elements is early detection and prompt treatment of malaria cases, especially in areas where health care facilities are inadequate. Establishing or ...

    Authors: Lalit K Das, Purushothaman Jambulingam and Candasamy Sadanandane

    Citation: Malaria Journal 2008 7:75

    Content type: Research

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  27. Knock-down resistance (kdr) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations at amino acid position 1014 of the ...

    Authors: Federica Santolamazza, Maria Calzetta, Josiane Etang, Elena Barrese, Ibrahima Dia, Adalgisa Caccone, Martin J Donnelly, Vincenzo Petrarca, Frederic Simard, Joao Pinto and Alessandra della Torre

    Citation: Malaria Journal 2008 7:74

    Content type: Research

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  28. To evaluate the cost-effectiveness of the first nationwide delivery of long-lasting insecticide-treated nets (LLITNs) as part of the 2004 measles vaccination campaign in Togo to all children between nine month...

    Authors: Dirk H Mueller, Virginia Wiseman, Dankom Bakusa, Kodjo Morgah, Aboudou Daré and Potougnima Tchamdja

    Citation: Malaria Journal 2008 7:73

    Content type: Research

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  29. In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populati...

    Authors: Vivian N Hawkins, Alyson Auliff, Surendra Kumar Prajapati, Kanchana Rungsihirunrat, Hapuarachchige C Hapuarachchi, Amanda Maestre, Michael T O'Neil, Qin Cheng, Hema Joshi, Kesara Na-Bangchang and Carol Hopkins Sibley

    Citation: Malaria Journal 2008 7:72

    Content type: Research

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  30. The diverse physiological and pathological role of nitric oxide in innate immune defenses against many intra and extracellular pathogens, have led to the development of various methods for determining nitric o...

    Authors: Arun Sharma, Kamaraju Raghavendra, Tridibesh Adak and Aditya P Dash

    Citation: Malaria Journal 2008 7:71

    Content type: Methodology

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  31. A simple real-time PCR assay using one set of primer and probe for rapid, sensitive and quantitative detection of Plasmodium species, with simultaneous differentiation of Plasmodium falciparum from the three othe...

    Authors: Innocent Safeukui, Pascal Millet, Sébastien Boucher, Laurence Melinard, Frédéric Fregeville, Marie-Catherine Receveur, Thierry Pistone, Pierre Fialon, Philippe Vincendeau, Hervé Fleury and Denis Malvy

    Citation: Malaria Journal 2008 7:70

    Content type: Methodology

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  32. To evaluate the performance of a novel malaria outbreak identification system in the epidemic prone rural area of Mpumalanga Province, South Africa, for timely identification of malaria outbreaks and guiding i...

    Authors: Marlize Coleman, Michael Coleman, Aaron M Mabuza, Gerdalize Kok, Maureen Coetzee and David N Durrheim

    Citation: Malaria Journal 2008 7:69

    Content type: Methodology

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  33. Severe malarial anaemia is a major complication of malaria infection and is multi-factorial resulting from loss of circulating red blood cells (RBCs) from parasite replication, as well as immune-mediated mecha...

    Authors: Tracey J Lamb and Jean Langhorne

    Citation: Malaria Journal 2008 7:68

    Content type: Research

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  34. Aggregated haemozoin crystals within malaria-infected erythrocytes confer susceptibility of parasitized cells to a magnetic field. Here the utility of this method for diagnosis of human malaria is evaluated in...

    Authors: Stephan Karl, Makindi David, Lee Moore, Brian T Grimberg, Pascal Michon, Ivo Mueller, Maciej Zborowski and Peter A Zimmerman

    Citation: Malaria Journal 2008 7:66

    Content type: Research

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  35. The work described in this article forms part of a study to suppress a population of the malaria vector Anopheles arabiensis in Northern State, Sudan, with the Sterile Insect Technique. No data have previously be...

    Authors: Michelle EH Helinski, Mo'awia M Hassan, Waleed M El-Motasim, Colin A Malcolm, Bart GJ Knols and Badria El-Sayed

    Citation: Malaria Journal 2008 7:65

    Content type: Methodology

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  36. Daily assessment of the percentage of erythrocytes that are infected ('percent-parasitaemia') across a time-course is a necessary step in many experimental studies of malaria, but represents a time-consuming a...

    Authors: Owen Proudfoot, Nathan Drew, Anja Scholzen, Sue Xiang and Magdalena Plebanski

    Citation: Malaria Journal 2008 7:62

    Content type: Methodology

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  37. In Papua New Guinea (PNG), combination therapy with amodiaquine (AQ) or chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) was introduced as first-line treatment against uncomplicated malaria in 2000.

    Authors: Jutta Marfurt, Ivo Müller, Albert Sie, Olive Oa, John C Reeder, Thomas A Smith, Hans-Peter Beck and Blaise Genton

    Citation: Malaria Journal 2008 7:61

    Content type: Research

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  38. Insecticide-treated bed nets (ITNs) range among the most effective measures of malaria prophylaxis, yet their implementation level in sub-Saharan Africa is still low. The goal of this study was to investigate ...

    Authors: Julia N Goesch, Norbert G Schwarz, Marie-Luise Decker, Sunny Oyakhirome, Lea B Borchert, Ulrich D Kombila, Marc Poetschke, Bertrand Lell, Saadou Issifou, Peter G Kremsner and Martin P Grobusch

    Citation: Malaria Journal 2008 7:60

    Content type: Research

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  39. Entomological surveys are of great importance in decision-making processes regarding malaria control strategies because they help to identify associations between vector abundance both species-specific ecology...

    Authors: Eliningaya J Kweka, Watoky MM Nkya, Aneth M Mahande, Charles Assenga, Franklin W Mosha, Ester E Lyatuu, Charles P Massenga, Edwin M Nyale, Stephen B Mwakalinga and Asanterabi Lowassa

    Citation: Malaria Journal 2008 7:59

    Content type: Research

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  40. Combination therapy has become a new paradigm in malaria treatment. Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its e...

    Authors: Germain Mandi, Frank P Mockenhaupt, Boubacar Coulibaly, Peter Meissner and Olaf Müller

    Citation: Malaria Journal 2008 7:58

    Content type: Research

    Published on:

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