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  1. The six-dose regimen of artemether-lumefantrine (AL) is now considered the gold standard for the treatment of uncomplicated Plasmodium falciparum malaria. There are few reports evaluating co-artemether in very yo...

    Authors: Catherine O Falade, Oluwatoyin O Ogunkunle, Hannah O Dada-Adegbola, Adegoke G Falade, Patricia Ibarra de Palacios, Philip Hunt, Mailis Virtanen, Ayoade M Oduola and Lateef A Salako

    Citation: Malaria Journal 2008 7:246

    Content type: Research

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  2. A fixed-dose combination of artemether-lumefantrine (AL, Coartem®) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium falcipar...

    Authors: Zulfiqarali G Premji, Salim Abdulla, Bernhards Ogutu, Alice Ndong, Catherine O Falade, Issaka Sagara, Nathan Mulure, Obiyo Nwaiwu and Gilbert Kokwaro

    Citation: Malaria Journal 2008 7:244

    Content type: Review

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  3. Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled tr...

    Authors: Bertrand Graz, Moussa Dicko, Merlin L Willcox, Bernard Lambert, Jacques Falquet, Mathieu Forster, Sergio Giani, Chiaka Diakite, Eugène M Dembele, Drissa Diallo and Hubert Barennes

    Citation: Malaria Journal 2008 7:242

    Content type: Research

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  4. Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine. Ato...

    Authors: Colin J Sutherland, Matt Laundy, Nicholas Price, Martina Burke, Quinton L Fivelman, Geoffrey Pasvol, John L Klein and Peter L Chiodini

    Citation: Malaria Journal 2008 7:240

    Content type: Research

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  5. Malaria rapid diagnostic tests (RDTs) may assist in diagnosis, improve prescribing practices and reduce potential drug resistance development. Without understanding operational issues or acceptance and usage b...

    Authors: Holly Ann Williams, Louise Causer, Emmy Metta, Aggrey Malila, Terrence O'Reilly, Salim Abdulla, S Patrick Kachur and Peter B Bloland

    Citation: Malaria Journal 2008 7:239

    Content type: Research

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  6. The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B ce...

    Authors: Amolo S Asito, Ann M Moormann, Chelimo Kiprotich, Zipporah W Ng'ang'a, Robert Ploutz-Snyder and Rosemary Rochford

    Citation: Malaria Journal 2008 7:238

    Content type: Research

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  7. Many countries have implemented artemisinin-based combination therapy (ACT) for the first-line treatment of malaria. Although many studies have been performed on efficacy and tolerability of the combination ar...

    Authors: Petra F Mens, Patrick Sawa, Sandra M van Amsterdam, Inge Versteeg, Sabah A Omar, Henk DFH Schallig and Piet A Kager

    Citation: Malaria Journal 2008 7:237

    Content type: Research

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  8. Malaria is the infectious disease causing the highest morbidity and mortality in Angola and due to widespread chloroquine (CQ) resistance, the country has recently changed its first-line treatment recommendati...

    Authors: Paula Figueiredo, Carla Benchimol, Dinora Lopes, Luís Bernardino, Virgílio E do Rosário, Luís Varandas and Fátima Nogueira

    Citation: Malaria Journal 2008 7:236

    Content type: Research

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  9. Two thirds of all falciparum malaria cases reported in the United Kingdom (UK) are acquired in West Africa (WA). To ensure recommendations and guidelines for malaria prophylaxis in travellers to West Africa co...

    Authors: Ron H Behrens, Bernadette Carroll, Valerie Smith and Neal Alexander

    Citation: Malaria Journal 2008 7:235

    Content type: Research

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  10. Intermittent preventive treatment with s ulphadoxine-pyrimethamine (SP) is recommended for reducing the risk of malaria in pregnancy and its consequences on mothers and babies (IPTp-SP). Indicators of implementat...

    Authors: Piero L Olliaro, Henriette Delenne, Moustafa Cisse, Malick Badiane, Alberto Olliaro, Michel Vaillant and Philippe Brasseur

    Citation: Malaria Journal 2008 7:234

    Content type: Research

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  11. The use of artemisinin derivatives has increased exponentially with the deployment of artemisinin combination therapy (ACT) in all malarious areas. They are highly effective and are considered safe, but in ani...

    Authors: Verena I Carrara, Aung P Phyo, Paw Nwee, Ma Soe, Hsar Htoo, Jaruwan Arunkamomkiri, Pratap Singhasivanon and François Nosten

    Citation: Malaria Journal 2008 7:233

    Content type: Research

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  12. Adequate malaria diagnosis and treatment remain major difficulties in rural sub-Saharan Africa. These issues deserve renewed attention in the light of first-line treatment with expensive artemisinin-combinatio...

    Authors: Charles Mwanziva, Seif Shekalaghe, Arnold Ndaro, Bianca Mengerink, Simon Megiroo, Frank Mosha, Robert Sauerwein, Chris Drakeley, Roly Gosling and Teun Bousema

    Citation: Malaria Journal 2008 7:232

    Content type: Research

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  13. Malaria epidemics remain a significant public health issue in the East African highlands. The aim of this study was to monitor temporal variations in vector densities in relation to changes in meteorological f...

    Authors: Mojca Kristan, Tarekegn A Abeku, James Beard, Michael Okia, Beth Rapuoda, James Sang and Jonathan Cox

    Citation: Malaria Journal 2008 7:231

    Content type: Research

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  14. Evaluation of mosquito responses towards different trap-bait combinations in field trials is a time-consuming process that can be shortened by experiments in contained semi-field systems. Possible use of the B...

    Authors: Wolfgang H Schmied, Willem Takken, Gerry F Killeen, Bart GJ Knols and Renate C Smallegange

    Citation: Malaria Journal 2008 7:230

    Content type: Research

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  15. Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncer...

    Authors: Wirichada Pongtavornpinyo, Shunmay Yeung, Ian M Hastings, Arjen M Dondorp, Nicholas PJ Day and Nicholas J White

    Citation: Malaria Journal 2008 7:229

    Content type: Research

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  16. The aim of this study was to analyse willingness to pay (WTP) and ability to pay (ATP) for ACT for children below five years of age in a rural setting in Tanzania before the introduction of artemisinin-based c...

    Authors: Eleonor C Saulo, Birger C Forsberg, Zul Premji, Scott M Montgomery and Anders Björkman

    Citation: Malaria Journal 2008 7:227

    Content type: Research

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  17. Anopheles funestus is a major malaria vector in southern Africa. Vector control relies on the use of insecticide chemicals to significantly reduce the number of malaria vectors by targeting that portion of the fe...

    Authors: Belinda L Spillings, Maureen Coetzee, Lizette L Koekemoer and Basil D Brooke

    Citation: Malaria Journal 2008 7:226

    Content type: Research

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  18. This study investigated the pharmacokinetics of fosmidomycin when given in combination with clindamycin at two dosage regimens in patients with acute uncomplicated falciparum malaria.

    Authors: Ronnatrai Ruangweerayut, Sornchai Looareesuwan, David Hutchinson, Anurak Chauemung, Vick Banmairuroi and Kesara Na-Bangchang

    Citation: Malaria Journal 2008 7:225

    Content type: Research

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  19. A sound local understanding of preventive measures and health-seeking behaviour is important for the effective control of malaria. The purpose of this study was to assess the knowledge, attitudes, practices an...

    Authors: Clémence Essé, Jürg Utzinger, Andres B Tschannen, Giovanna Raso, Constanze Pfeiffer, Stefanie Granado, Benjamin G Koudou, Eliézer K N'Goran, Guéladio Cissé, Olivier Girardin, Marcel Tanner and Brigit Obrist

    Citation: Malaria Journal 2008 7:224

    Content type: Research

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  20. Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount of DNA. Such...

    Authors: Rachel Daniels, Sarah K Volkman, Danny A Milner, Nira Mahesh, Daniel E Neafsey, Daniel J Park, David Rosen, Elaine Angelino, Pardis C Sabeti, Dyann F Wirth and Roger C Wiegand

    Citation: Malaria Journal 2008 7:223

    Content type: Methodology

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  21. Cloning of parasites by limiting dilution is an essential and rate-limiting step in many aspects of malaria research including genomic and genetic manipulation studies. The standard Giemsa-stained blood smears...

    Authors: Steven P Maher, Bharath Balu, Doug A Shoue, Matthew E Weissenbach and John H Adams

    Citation: Malaria Journal 2008 7:222

    Content type: Methodology

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  22. Parasite-based diagnosis of malaria by microscopy requires laboratory skills that are generally unavailable at peripheral health facilities. Rapid diagnostic tests (RDTs) require less expertise, but accuracy u...

    Authors: Daniel J Kyabayinze, James K Tibenderana, George W Odong, John B Rwakimari and Helen Counihan

    Citation: Malaria Journal 2008 7:221

    Content type: Research

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  23. Plasmodium vivax accounts for about 40% of all malaria infection in Ethiopia. Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country. The first report of CQ treatment failure i...

    Authors: Hiwot Teka, Beyene Petros, Lawrence Yamuah, Gezahegn Tesfaye, Ibrahim Elhassan, Simon Muchohi, Gilbert Kokwaro, Abraham Aseffa and Howard Engers

    Citation: Malaria Journal 2008 7:220

    Content type: Research

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  24. Rapid diagnostic tests (RDTs) are becoming increasingly indispensable in malaria management, as a means of increasing the accuracy of diagnosis. The WHO has issued recommendations, but the selection of the mos...

    Authors: Natacha Mariette, Céline Barnadas, Christiane Bouchier, Magali Tichit and Didier Ménard

    Citation: Malaria Journal 2008 7:219

    Content type: Research

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  25. The efficient allocation of financial resources for malaria control and the optimal distribution of appropriate interventions require accurate information on the geographic distribution of malaria risk and of ...

    Authors: Andrew J Tatem, Carlos A Guerra, Caroline W Kabaria, Abdisalan M Noor and Simon I Hay

    Citation: Malaria Journal 2008 7:218

    Content type: Research

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  26. Reported malaria cases in rice growing areas in western Tajikistan were at the root of a rapid appraisal of the local malaria situation in a selected agro-ecological setting where only scarce information was a...

    Authors: Barbara Matthys, Tohir Sherkanov, Saifudin S Karimov, Zamonidin Khabirov, Till Mostowlansky, Jürg Utzinger and Kaspar Wyss

    Citation: Malaria Journal 2008 7:217

    Content type: Research

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  27. Across tropical Africa the bulk of malaria-related morbidity and mortality is particularly high during childhood. Classical malariometric surveys have relied on assessing malaria infection prevalence. The last...

    Authors: Samuel Mabunda, Sónia Casimiro, Llorenç Quinto and Pedro Alonso

    Citation: Malaria Journal 2008 7:216

    Content type: Research

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  28. In Thailand, South Africa and Zanzibar, a decrease in malaria morbidity was observed following the introduction of artemisinin-based combination therapy (ACT). In Senegal, therapeutic trials supervised the in ...

    Authors: Sophie Sarrassat, Paul Senghor and Jean Yves Le Hesran

    Citation: Malaria Journal 2008 7:215

    Content type: Research

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  29. Intra-specific variation in sperm length influences male reproductive success in several species of insects. In males of the malaria vector Anopheles gambiae, sperm length is highly variable but the significance ...

    Authors: Maarten J Voordouw, Jacob C Koella and Hilary Hurd

    Citation: Malaria Journal 2008 7:214

    Content type: Research

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  30. Intermittent preventive treatment of malaria in infants (IPTi) reduces the incidence of clinical malaria. However, before making decisions about implementation, it is essential to ensure that IPTi is acceptabl...

    Authors: Robert Pool, Adiel Mushi, Joanna Armstrong Schellenberg, Mwifadhi Mrisho, Pedro Alonso, Catherine Montgomery, Marcel Tanner, Hassan Mshinda and David Schellenberg

    Citation: Malaria Journal 2008 7:213

    Content type: Research

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  31. There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of isolates from patients with differen...

    Authors: Pannapa Susomboon, Moritoshi Iwagami, Noppadon Tangpukdee, Srivicha Krusood, Sornchai Looareesuwan and Shigeyuki Kano

    Citation: Malaria Journal 2008 7:212

    Content type: Research

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  32. In order to establish a successful infection in the human host, the malaria parasite Plasmodium falciparum must establish interactions with a variety of human proteins on the surface of different cell types, as w...

    Authors: Marissa Vignali, Anastasia McKinlay, Douglas J LaCount, Rakesh Chettier, Russell Bell, Sudhir Sahasrabudhe, Robert E Hughes and Stanley Fields

    Citation: Malaria Journal 2008 7:211

    Content type: Research

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  33. Haematological changes associated with malaria in pregnancy are not well documented, and have focused predominantly on anaemia. Examined here is thrombocytopaenia in pregnant women infected with Plasmodium falcip...

    Authors: Saw Oo Tan, Rose McGready, Julien Zwang, Mupawjay Pimanpanarak, Kanlaya Sriprawat, Kyaw Lai Thwai, Yoe Moo, Elizabeth A Ashley, Bridget Edwards, Pratap Singhasivanon, Nicholas J White and François Nosten

    Citation: Malaria Journal 2008 7:209

    Content type: Research

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  34. Certain distinctive components of the severe systemic inflammatory syndrome are now well-recognized to be common to malaria, sepsis, viral infections, and post-trauma illness. While their connection with cytok...

    Authors: Ian A Clark, Alison C Budd and Lisa M Alleva

    Citation: Malaria Journal 2008 7:208

    Content type: Review

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  35. The patho-mechanisms leading to brain damage due to cerebral malaria (CM) are yet not fully understood. Immune-mediated and ischaemic mechanisms have been implicated. The role of complement factors C1q, C3 and...

    Authors: Peter Lackner, Christian Hametner, Ronny Beer, Christoph Burger, Gregor Broessner, Raimund Helbok, Cornelia Speth and Erich Schmutzhard

    Citation: Malaria Journal 2008 7:207

    Content type: Research

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  36. Malaria has re-emerged in Anhui Province, China, and this province was the most seriously affected by malaria during 2005–2006. It is necessary to understand the spatial distribution of malaria cases and to id...

    Authors: Wenyi Zhang, Liping Wang, Liqun Fang, Jiaqi Ma, Youfu Xu, Jiafu Jiang, Fengming Hui, Jianjun Wang, Song Liang, Hong Yang and Wuchun Cao

    Citation: Malaria Journal 2008 7:206

    Content type: Research

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  37. Maps of the distribution of malaria vectors are useful tools for stratification of malaria risk and for selective vector control strategies. Although the distribution of members of the Anopheles gambiae complex i...

    Authors: Nafomon Sogoba, Penelope Vounatsou, Magaran M Bagayoko, Seydou Doumbia, Guimogo Dolo, Laura Gosoniu, Sékou F Traoré, Thomas A Smith and Yéya T Touré

    Citation: Malaria Journal 2008 7:205

    Content type: Research

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  38. A subset of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1SM) is involved in the cytoadherence of P. falciparum-infected red blood cells (iRBC) contributing to the pathogenesis of severe disease...

    Authors: Pamela A Magistrado, Trine Staalsoe, Thor G Theander, Lars Hviid and Anja TR Jensen

    Citation: Malaria Journal 2008 7:204

    Content type: Research

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  39. In vitro cultivation of Plasmodium falciparum is usually carried out through the continuous preservation of infected erythrocytes deposited in static thin layers of settled haematocrit. This technique, called the...

    Authors: Jordi Ferrer, Marina D Rosal, Jaume M Vidal, Clara Prats, Joaquim Valls, Esperanza A Herreros, Daniel López and Domingo Gargallo

    Citation: Malaria Journal 2008 7:203

    Content type: Methodology

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  40. The accuracy of malaria diagnosis has received renewed interest in recent years due to changes in treatment policies in favour of relatively high-cost artemisinin-based combination therapies. The use of rapid ...

    Authors: Tarekegn A Abeku, Mojca Kristan, Caroline Jones, James Beard, Dirk H Mueller, Michael Okia, Beth Rapuoda, Brian Greenwood and Jonathan Cox

    Citation: Malaria Journal 2008 7:202

    Content type: Research

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  41. Home Management of Malaria (HMM) is one of the key strategies to reduce the burden of malaria for vulnerable population in endemic countries. It is based on the evidence that well-trained communities health wo...

    Authors: Alfred B Tiono, Youssouf Kaboré, Abdoulaye Traoré, Nathalie Convelbo, Franco Pagnoni and Sodiomon B Sirima

    Citation: Malaria Journal 2008 7:201

    Content type: Research

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  42. Prescribing antimalarial medicines based on parasite confirmed diagnosis of malaria is critical to rational drug use and optimal outcome of febrile illness. The impact of microscopy-based versus clinical-based...

    Authors: Billy Ngasala, Marycelina Mubi, Marian Warsame, Max G Petzold, Amos Y Massele, Lars L Gustafsson, Goran Tomson, Zul Premji and Anders Bjorkman

    Citation: Malaria Journal 2008 7:199

    Content type: Research

    Published on:

  43. Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) reduces the incidence of malaria episodes in young children. The exact mechanism by which the protective effect is media...

    Authors: Jürgen May, Samuel Adjei, Wibke Busch, Julian J Gabor, Saadou Issifou, Robin Kobbe, Benno Kreuels, Bertrand Lell, Norbert G Schwarz, Ohene Adjei, Peter G Kremsner and Martin P Grobusch

    Citation: Malaria Journal 2008 7:198

    Content type: Research

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  44. Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites to the cost-effective c...

    Authors: Lyn-Marie Birkholtz, Gregory Blatch, Theresa L Coetzer, Heinrich C Hoppe, Esmaré Human, Elizabeth J Morris, Zoleka Ngcete, Lyndon Oldfield, Robyn Roth, Addmore Shonhai, Linda Stephens and Abraham I Louw

    Citation: Malaria Journal 2008 7:197

    Content type: Review

    Published on:

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