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  1. Despite intensive research, malaria remains a major health concern for non-immune residents and travelers in malaria-endemic regions. Efficient adjunctive therapies against life-threatening complications such ...

    Authors: Katrien Deroost, Natacha Lays, Sam Noppen, Erik Martens, Ghislain Opdenakker and Philippe E Van den Steen
    Citation: Malaria Journal 2012 11:166
  2. International public health workers are challenged by a burden of arthropod-borne disease that remains elevated despite best efforts in control programmes. With this challenge comes the opportunity to develop ...

    Authors: Nicole L Achee, Michael J Bangs, Robert Farlow, Gerry F Killeen, Steve Lindsay, James G Logan, Sarah J Moore, Mark Rowland, Kevin Sweeney, Steve J Torr, Laurence J Zwiebel and John P Grieco
    Citation: Malaria Journal 2012 11:164
  3. Several studies indicate that people of the Fulani ethnic group are less susceptible to malaria compared to those of other ethnic groups living sympatrically in Africa, including the Dogon ethnic group. Althou...

    Authors: Silvia Portugal, Didier Doumtabe, Boubacar Traore, Louis H Miller, Marita Troye-Blomberg, Ogobara K Doumbo, Amagana Dolo, Susan K Pierce and Peter D Crompton
    Citation: Malaria Journal 2012 11:162
  4. Malaria is commonly considered a disease of the poor, but there is very little evidence of a possible two-way causality in the association between malaria and poverty. Until now, limitations to examine that du...

    Authors: Marcia Caldas de Castro and Monica G Fisher
    Citation: Malaria Journal 2012 11:161
  5. In Côte d’Ivoire, an estimated 767,000 disability-adjusted life years are due to malaria, placing the country at position number 14 with regard to the global burden of malaria. Risk maps are important to guide...

    Authors: Giovanna Raso, Nadine Schur, Jürg Utzinger, Benjamin G Koudou, Emile S Tchicaya, Fabian Rohner, Eliézer K N’Goran, Kigbafori D Silué, Barbara Matthys, Serge Assi, Marcel Tanner and Penelope Vounatsou
    Citation: Malaria Journal 2012 11:160
  6. The malaria aldolase is widely used as rapid diagnostic test (RDT), but the efficacy in aspect of its serological effectiveness in diagnosis is not known. The genetic variation of Korean isolates was analysed ...

    Authors: Jung-Yeon Kim, Hyung-Hwan Kim, Hyun-ll Shin, Youngjoo Sohn, Hyuck Kim, Sang-Wook Lee, Won-Ja Lee and Hyeong-Woo Lee
    Citation: Malaria Journal 2012 11:159
  7. Severe falciparum malaria is associated with considerable rates of mortality, despite the administration of appropriate anti-malarial treatment. Since overall survival is associated with total parasite biomass...

    Authors: Lorenz Auer-Hackenberg, Thomas Staudinger, Andja Bojic, Gottfried Locker, Gerda C Leitner, Wolfgang Graninger, Stefan Winkler, Michael Ramharter and Nina Worel
    Citation: Malaria Journal 2012 11:158
  8. The malaria burden remains a major public health concern, especially in sub-Saharan Africa. The complex biology of Plasmodium, the apicomplexan parasite responsible for this disease, challenges efforts to develop...

    Authors: Piero Bagnaresi, Nilana MT Barros, Diego M Assis, Pollyana MS Melo, Raphael G Fonseca, Maria A Juliano, João B Pesquero, Luiz Juliano, Philip J Rosenthal, Adriana K Carmona and Marcos L Gazarini
    Citation: Malaria Journal 2012 11:156
  9. Viewing Plasmodium in Romanovsky-stained blood has long been considered the gold standard for diagnosis and a cornerstone in management of the disease. This method however, requires a subjective evaluation by ...

    Authors: William R Prescott, Robert G Jordan, Martin P Grobusch, Vernon M Chinchilli, Immo Kleinschmidt, Joseph Borovsky, Mark Plaskow, Miguel Torrez, Maximo Mico and Christopher Schwabe
    Citation: Malaria Journal 2012 11:155
  10. Genetic factors play a key role in determining resistance/susceptibility to infectious disease. Susceptibility of the human host to malaria infection has been reported to be influenced by genetic factors, whic...

    Authors: Edith C Bougouma, Alfred B Tiono, Alphonse Ouédraogo, Issiaka Soulama, Amidou Diarra, Jean-Baptiste Yaro, Espérance Ouédraogo, Souleymane Sanon, Amadou T Konaté, Issa Nébié, Nora L Watson, Megan Sanza, Tina JT Dube and Sodiomon B Sirima
    Citation: Malaria Journal 2012 11:154
  11. A practical and simple regimen for all malaria species is needed towards malaria elimination in Indonesia. It is worth to compare the efficacy and safety of a single dose of artemisinin-naphthoquine (AN) with ...

    Authors: Emiliana Tjitra, Armedy R Hasugian, Hadjar Siswantoro, Budi Prasetyorini, Riyanti Ekowatiningsih, Endah A Yusnita, Telly Purnamasari, Srilaning Driyah, Ervi Salwati, Eni Yuwarni, Lidwina Januar, Joseph Labora, Bambang Wijayanto, Fajar Amansyah, Tersila AD Dedang and Asep Purnama
    Citation: Malaria Journal 2012 11:153
  12. Although early diagnosis and prompt treatment is an important strategy for control of malaria, using fever to initiate presumptive treatment with expensive artemisinin combination therapy is a major challenge;...

    Authors: Acleus S M Rutta, Filbert Francis, Bruno P Mmbando, Deus S Ishengoma, Samwel H Sembuche, Ezekiel K Malecela, Johari Y Sadi, Mathias L Kamugisha and Martha M Lemnge
    Citation: Malaria Journal 2012 11:152
  13. In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been co...

    Authors: Seunghyun Kang, Jongwoo Jung, Sanghui Lee, Heeseung Hwang and Won Kim
    Citation: Malaria Journal 2012 11:151
  14. Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda...

    Authors: Atis Muehlenbachs, Carolyn Nabasumba, Rose McGready, Eleanor Turyakira, Benon Tumwebaze, Mehul Dhorda, Dan Nyehangane, Aisha Nalusaji, Franois Nosten, Philippe J Guerin and Patrice Piola
    Citation: Malaria Journal 2012 11:150
  15. Quality control of drugs in formulations is still a major challenge in developing countries. For the quality control of artesunate and amodiaquine tablets in fixed-dose combination, only liquid chromatographic...

    Authors: N’Cho Christophe Amin, Marie-Dominique Blanchin, Michèle Aké, Jérôme Montels and Huguette Fabre
    Citation: Malaria Journal 2012 11:149
  16. Clinical observations suggest that Canadian-born (CB) travellers are prone to more severe malaria, characterized by higher parasite density in the blood, and severe symptoms, such as cerebral malaria and renal...

    Authors: Gregory MacMullin, Ronald Mackenzie, Rachel Lau, Julie Khang, Haibo Zhang, Nimerta Rajwans, W Conrad Liles and Dylan R Pillai
    Citation: Malaria Journal 2012 11:148
  17. Artemisinin-based combination therapies (ACT) are widely used in African countries, including Cameroon. Between 2005 and 2007, five randomized studies comparing different treatment arms among artesunate-amodia...

    Authors: Solange Whegang Youdom, Adeline Samson, Leonardo K Basco and Jean-Christophe Thalabard
    Citation: Malaria Journal 2012 11:147
  18. The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone‐proguanil (Malarone®) has shown high efficacy against Pla...

    Authors: Nathalie Wurtz, Aurélie Pascual, Adeline Marin-Jauffre, Housem Bouchiba, Nicolas Benoit, Marc Desbordes, Maryse Martelloni, Vincent Pommier de Santi, Georges Richa, Nicolas Taudon, Bruno Pradines and Sébastien Briolant
    Citation: Malaria Journal 2012 11:146
  19. Highly sensitive polymerase chain reaction (PCR) methods offer an alternative to the light microscopy examination of mosquito salivary glands for the determination of malaria sporozoite rates in wild caught fe...

    Authors: Desmond H Foley, Genelle Harrison, Jittawadee R Murphy, Megan Dowler, Leopoldo M Rueda and Richard C Wilkerson
    Citation: Malaria Journal 2012 11:145
  20. Infection by Plasmodium vivax has been considered rarely threatening to life, but recent studies challenge this notion. This study documented the frequency and character of severe illness in paediatric patients a...

    Authors: Salma Shaikh, Hafeezullah Memon, Bhagchand Iohano, Amna Shaikh, Imran Ahmed and J Kevin Baird
    Citation: Malaria Journal 2012 11:144
  21. Artemisinin-based combination therapy (ACT) is currently recommended as first-line treatment for uncomplicated malaria, but of concern, it has been observed that the effectiveness of the main artemisinin deriv...

    Authors: Kris M Jamsen, Stephen B Duffull, Joel Tarning, Niklas Lindegardh, Nicholas J White and Julie A Simpson
    Citation: Malaria Journal 2012 11:143
  22. Dengue and malaria are two major arthropod-borne infections in tropical areas, but dual infections were only described for the first time in 2005. Reports of these concomitant infections are scarce and there i...

    Authors: Loïc Epelboin, Matthieu Hanf, Philippe Dussart, Sihem Ouar-Epelboin, Félix Djossou, Mathieu Nacher and Bernard Carme
    Citation: Malaria Journal 2012 11:142
  23. Malaria during pregnancy, particularly Plasmodium falciparum malaria, has been linked to increased morbidity and mortality, which must be reduced by both preventive measures and effective case management. The Wor...

    Authors: Christine Manyando, Kassoum Kayentao, Umberto D’Alessandro, Henrietta U Okafor, Elizabeth Juma and Kamal Hamed
    Citation: Malaria Journal 2012 11:141
  24. Artemisinin-based combination therapy (ACT) has been promoted as a means to reduce malaria transmission due to their ability to kill both asexual blood stages of malaria parasites, which sustain infections ove...

    Authors: Rashid A Khatib, Jacek Skarbinski, Joseph D Njau, Catherine A Goodman, Berty F Elling, Elizeus Kahigwa, Jacquelin M Roberts, John R MacArthur, Julie R Gutman, Abdunoor M Kabanywanyi, Ernest E Smith, Masha F Somi, Thomas Lyimo, Alex Mwita, Blaise Genton, Marcel Tanner…
    Citation: Malaria Journal 2012 11:140
  25. Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal dis...

    Authors: Carine Van Malderen, Jean-Pierre Van Geertruyden, Sonia Machevo, Raquel González, Quique Bassat, Ambrose Talisuna, Adoke Yeka, Carolyn Nabasumba, Patrice Piola, Atwine Daniel, Eleanor Turyakira, Pascale Forret, Chantal Van Overmeir, Harry Van Loen, Annie Robert and Umberto D’ Alessandro
    Citation: Malaria Journal 2012 11:139
  26. Real-time quantitative nucleic acid sequence-based amplification (QT-NASBA) is a sensitive method for detection of sub-microscopic gametocytaemia by measuring gametocyte-specific mRNA. Performing analysis on f...

    Authors: Michael Pritsch, Andreas Wieser, Victor Soederstroem, David Poluda, Teferi Eshetu, Michael Hoelscher, Soeren Schubert, Jonathan Shock, Thomas Loescher and Nicole Berens-Riha
    Citation: Malaria Journal 2012 11:138
  27. As HIV becomes a chronic infection, an increasing number of HIV-infected patients are travelling to malaria-endemic areas. Association of malaria with HIV/AIDS can be clinically severe. Severe falciparum malar...

    Authors: Silvia García-Bujalance, Carolina Navarro-San Francisco, José M Rubio, José R Arribas and Avelino Gutierrez
    Citation: Malaria Journal 2012 11:136
  28. Plasmodium vivax threatens nearly half the world’s population and is a significant impediment to achievement of the millennium development goals. It is an important, but incompletely understood, cause of anaemia....

    Authors: Nicholas M Douglas, Nicholas M Anstey, Pierre A Buffet, Jeanne R Poespoprodjo, Tsin W Yeo, Nicholas J White and Ric N Price
    Citation: Malaria Journal 2012 11:135
  29. Resistance to sulphadoxine-pyrimethamine (SP) in Plasmodium falciparum parasites is associated with mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes and has spread worldwi...

    Authors: Nnaemeka C Iriemenam, Monica Shah, Wangeci Gatei, Anna M van Eijk, John Ayisi, Simon Kariuki, Jodi Vanden Eng, Simon O Owino, Ashima A Lal, Yusuf O Omosun, Kephas Otieno, Meghna Desai, Feiko O ter Kuile, Bernard Nahlen, Julie Moore, Mary J Hamel…
    Citation: Malaria Journal 2012 11:134
  30. Anopheles gambiae sensu stricto (s.s.) is a primary vector of Plasmodium falciparum in sub-Saharan Africa. Although some physiological differences among molecular and chromosomal forms of this species have been d...

    Authors: Rebecca T Trout Fryxell, Catelyn C Nieman, Abdrahamane Fofana, Yoosook Lee, Sekou F Traoré, Anthony J Cornel, Shirley Luckhart and Gregory C Lanzaro
    Citation: Malaria Journal 2012 11:133
  31. Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to asses...

    Authors: Pauline Byakika-Kibwika, Mohammed Lamorde, Jonathan Mayito, Lillian Nabukeera, Harriet Mayanja-Kizza, Elly Katabira, Warunee Hanpithakpong, Celestino Obua, Nadine Pakker, Niklas Lindegardh, Joel Tarning, Peter J de Vries and Concepta Merry
    Citation: Malaria Journal 2012 11:132
  32. Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins...

    Authors: Dylan R Pillai, Rachel Lau, Krishna Khairnar, Rosalba Lepore, Allegra Via, Henry M Staines and Sanjeev Krishna
    Citation: Malaria Journal 2012 11:131
  33. The risk of Plasmodium falciparum malaria increases during pregnancy and at early postpartum. Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to th...

    Authors: Alfredo Mayor, Elisa Serra-Casas, Eduard Rovira-Vallbona, Alfons Jiménez, Llorenç Quintó, Betuel Sigaúque, Carlota Dobaño, Azucena Bardají, Pedro L Alonso and Clara Menéndez
    Citation: Malaria Journal 2012 11:130
  34. Members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion antigen family are major contributors to the pathogenesis of P. falciparum malaria infections. The PfEMP1-encoding var genes a...

    Authors: Christian W Wang, Thomas Lavstsen, Dominique C Bengtsson, Pamela A Magistrado, Sanne S Berger, Andrea M Marquard, Michael Alifrangis, John P Lusingu, Thor G Theander and Louise Turner
    Citation: Malaria Journal 2012 11:129
  35. Plasmodium falciparum exports proteins that remodel the erythrocyte membrane. One such protein, called Pf155/RESA (RESA1) contributes to parasite fitness, optimizing parasite survival during febrile episodes. Res...

    Authors: Rémy Durand, Florence Migot-Nabias, Valérie Andriantsoanirina, Elise Seringe, Firmine Viwami, Gratien Sagbo, Francis Lalya, Philippe Deloron, Odile Mercereau-Puijalon and Serge Bonnefoy
    Citation: Malaria Journal 2012 11:128
  36. In the Adami Tulu District, indoor residual spraying (IRS) and insecticide-treated nets (ITNs) has been the main tool used to control malaria. The purpose of this study was to assess the effect of IRS and ITNs...

    Authors: Damtew Bekele, Yeshambel Belyhun, Beyene Petros and Wakgari Deressa
    Citation: Malaria Journal 2012 11:127
  37. In malaria endemic areas, continuous exposure to Plasmodium parasites leads to asymptomatic carriers that provide a fundamental reservoir of parasites, contributing to the persistence of malaria transmission. The...

    Authors: Samaneh Zoghi, Akram A Mehrizi, Ahmad Raeisi, Ali A Haghdoost, Habibollah Turki, Reza Safari, Asadallah Ahmadi Kahanali and Sedigheh Zakeri
    Citation: Malaria Journal 2012 11:126
  38. The aim of this study was to investigate cytochrome P450 2C8*2 (CYP2C8*2) distribution and allele frequency in three populations from West and East Africa exposed to Plasmodium falciparum malaria. CYP2C8 enzyme i...

    Authors: Giacomo M Paganotti, Silvia Gramolelli, Francesca Tabacchi, Gianluca Russo, David Modiano, Mario Coluzzi and Rita Romano
    Citation: Malaria Journal 2012 11:125
  39. Molecular and cellular studies of Plasmodium falciparum require cloning of parasites by limiting dilution cultivation, typically performed in microplates. The parasite's slow replication rate combined with labori...

    Authors: Brian Lyko, Elizabeth A Hammershaimb, Wang Nguitragool, Thomas E Wellems and Sanjay A Desai
    Citation: Malaria Journal 2012 11:124
  40. Progress in malaria control over the past decade has been striking, with malaria mortality rates falling by approximately one quarter globally and more than a third in the World Health Organization African Reg...

    Authors: Robert D Newman
    Citation: Malaria Journal 2012 11:123
  41. Considerable declines in malaria have accompanied increased funding for control since the year 2000, but historical failures to maintain gains against the disease underscore the fragility of these successes. A...

    Authors: Justin M Cohen, David L Smith, Chris Cotter, Abigail Ward, Gavin Yamey, Oliver J Sabot and Bruno Moonen
    Citation: Malaria Journal 2012 11:122
  42. Honduras is a tropical country with more than 70% of its population living at risk of being infected with either Plasmodium vivax or Plasmodium falciparum. Laboratory diagnosis is a very important factor for adeq...

    Authors: Gustavo A Fontecha, Meisy Mendoza, Engels Banegas, Mitra Poorak, Alexandre M De Oliveira, Tamara Mancero, Venkatachalam Udhayakumar, Naomi W Lucchi and Rosa E Mejia
    Citation: Malaria Journal 2012 11:119
  43. Artemisinin-based combination therapy (ACT) for treating malaria has activity against immature gametocytes. In theory, this property may complement the effect of terminating otherwise lengthy malaria infection...

    Authors: Bernadette J Huho, Gerard F Killeen, Heather M Ferguson, Adriana Tami, Christian Lengeler, J Derek Charlwood, Aniset Kihonda, Japhet Kihonda, S Patrick Kachur, Thomas A Smith and Salim MK Abdulla
    Citation: Malaria Journal 2012 11:118
  44. Malaria is a significant threat to population health in the border areas of Yunnan Province, China. How to accurately measure malaria transmission is an important issue. This study aimed to examine the role of...

    Authors: Yan Bi, Wenbiao Hu, Huaxin Liu, Yujiang Xiao, Yuming Guo, Shimei Chen, Laifa Zhao and Shilu Tong
    Citation: Malaria Journal 2012 11:117
  45. Malaria parasites (Plasmodium sp.), including new species, have recently been discovered as low grade mixed infections in three wild chimpanzees (Pan troglodytes schweinfurthii) sampled randomly in Kibale Nationa...

    Authors: Sabrina Krief, Florence Levrero, Jean-Michel Krief, Supinya Thanapongpichat, Mallika Imwong, Georges Snounou, John M Kasenene, Marie Cibot and Jean-Charles Gantier
    Citation: Malaria Journal 2012 11:116
  46. Genetic polymophisms of the Duffy antigen receptor for the chemokines (DARC) gene successfully protected against blood stage infection by Plasmodium vivax infection. The Fy (a-, b-) phenotype is predominant among...

    Authors: Agnieszka Kempińska-Podhorodecka, Oktawian Knap, Arleta Drozd, Mariusz Kaczmarczyk, Miroslaw Parafiniuk, Milosz Parczewski and Andrzej Ciechanowicz
    Citation: Malaria Journal 2012 11:115
  47. Pregnant women are more susceptible to malaria than their non-pregnant counterparts. Less is known about the risk of malaria in the postpartum period. The epidemiology of postpartum malaria was systematically ...

    Authors: Machteld E Boel, Marcus J Rijken, Bernard J Brabin, François Nosten and Rose McGready
    Citation: Malaria Journal 2012 11:114
  48. Regular monitoring of the levels of anti-malarial resistance of Plasmodium falciparum is an essential policy to adapt therapy and improve malaria control. This monitoring can be facilitated by using molecular too...

    Authors: Sandie Menard, Isabelle Morlais, Rachida Tahar, Collins Sayang, Pembe Issamou Mayengue, Xavier Iriart, Françoise Benoit-Vical, Brigitte Lemen, Jean-François Magnaval, Parfait Awono-Ambene, Leonardo K Basco and Antoine Berry
    Citation: Malaria Journal 2012 11:113

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