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  1. Content type: Research

    The inflammatory nature of falciparum malaria has been acknowledged since increased circulating levels of tumour necrosis factor (TNF) were first measured, but precisely where the mediators downstream from thi...

    Authors: Ian A Clark, Melissa M Awburn, Richard O Whitten, Clive G Harper, N George Liomba, Malcolm E Molyneux and Terrie E Taylor

    Citation: Malaria Journal 2003 2:6

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  2. Content type: Research

    Resistance of Plasmodium falciparum to atovaquone in vitro and in vivo has been associated to mutations in the parasite cytochrome b gene.

    Authors: Babett Schwöbel, Michael Alifrangis, Ali Salanti and Tomas Jelinek

    Citation: Malaria Journal 2003 2:5

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  3. Content type: Research

    There is no known biochemical basis for the adverse neurological events attributed to mefloquine. Identification of genes modulated by toxic agents using microarrays may provide sufficient information to gener...

    Authors: Geoffrey S Dow

    Citation: Malaria Journal 2003 2:4

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  4. Content type: Research

    Anopheles gambiae is the main vector of Plasmodium falciparum in Africa. The mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted. Despite the central role of ...

    Authors: GI Prévot, C Laurent-Winter, F Rodhain and C Bourgouin

    Citation: Malaria Journal 2003 2:1

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  5. Content type: Methodology

    The development and implementation of innovative vector control strategies for malaria control in Africa requires in-depth ecological studies in contained semi-field environments. This particularly applies to ...

    Authors: Bart GJ Knols, Basilio N Njiru, Evan M Mathenge, Wolfgang R Mukabana, John C Beier and Gerry F Killeen

    Citation: Malaria Journal 2002 1:19

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  6. Content type: Research

    Many studies have suggested that variability in the attractiveness of humans to host-seeking mosquitoes is caused by differences in the make-up of body emanations, and olfactory signals in particular. Most inv...

    Authors: Wolfgang R Mukabana, Willem Takken, Richard Coe and Bart GJ Knols

    Citation: Malaria Journal 2002 1:17

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  7. Content type: Research

    Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to c...

    Authors: Nadine Fievet, Germaine Tami, Bertrand Maubert, Marlène Moussa, Ian K Shaw, Michel Cot, Anthony A Holder, Gérard Chaouat and Philippe Deloron

    Citation: Malaria Journal 2002 1:16

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  8. Content type: Research

    Insecticide-treated materials (ITMs) are effective in substantially reducing the burden of malaria and other vector-borne diseases; but how can high coverage rates of ITMs be achieved and maintained? In south ...

    Authors: Axel Kroeger, Ana Aviñna, José Ordoñnez-Gonzalez and Celia Escandon

    Citation: Malaria Journal 2002 1:15

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  9. Content type: Methodology

    Sequential analysis enables repeated statistical analyses to be performed throughout a trial recruitment period, while maintaining a pre-specified power and type I error. Thus the trial can be stopped as soon ...

    Authors: Stéphane Ranque, Sékéné Badiaga, Jean Delmont and Philippe Brouqui

    Citation: Malaria Journal 2002 1:13

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  10. Content type: Research

    The increasing levels of Plasmodium falciparum resistance to chloroquine (CQ) in Thailand have led to the use of alternative antimalarials, which are at present also becoming ineffective. In this context, any str...

    Authors: Dinora Lopes, Kanchana Rungsihirunrat, Fátima Nogueira, Aree Seugorn, José Pedro Gil, Virgilio E do Rosário and Pedro Cravo

    Citation: Malaria Journal 2002 1:12

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  11. Content type: Research

    Results from numerous studies point convincingly to correlations between mutations at selected genes and phenotypic resistance to antimalarials in Plasmodium falciparum isolates. In order to move molecular assays...

    Authors: Tomas Jelinek, Gabriele Peyerl-Hoffmann, Nikolai Mühlberger, Ole Wichmann, Michael Wilhelm, Nadja Schmider, Martin P Grobusch, Frank von Sonnenburg, Joaquim Gascon, Hermann Laferl, Christoph Hatz, Michael Alifrangis, Gerd Burchard, Paul McWhinney, Marco Schulze, Herwig Kollaritsch…

    Citation: Malaria Journal 2002 1:11

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  12. Content type: Research

    Plasmodium-refractory mosquitoes are being rapidly developed for malaria control but will only succeed if they can successfully compete for mates when released into the wild. Pre-copulatory behavioural traits mai...

    Authors: FM Okanda, A Dao, BN Njiru, J Arija, HA Akelo, Y Touré, A Odulaja, JC Beier, JI Githure, G Yan, LC Gouagna, BGJ Knols and GF Killeen

    Citation: Malaria Journal 2002 1:10

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  13. Content type: Research

    Much communicable disease control research has had little impact on local control programme policy and practice for want of an operational component. The operational research model – the systematic search for ...

    Authors: David N Durrheim, Richard Speare and Anthony D Harries

    Citation: Malaria Journal 2002 1:9

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  14. Content type: Opinion

    Based on sensitivity analysis of the MacDonald-Ross model, it has long been argued that the best way to reduce malaria transmission is to target adult female mosquitoes with insecticides that can reduce the lo...

    Authors: Gerry F Killeen, Ulrike Fillinger and Bart GJ Knols

    Citation: Malaria Journal 2002 1:8

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  15. Content type: Methodology

    Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would be important to determine whether there are CD4 T cells t...

    Authors: Latifu A Sanni, Catherine EM Allsopp, Lieke Reubsaet, Ambaliou Sanni, Chris Newbold, Virander S Chauhan and Jean Langhorne

    Citation: Malaria Journal 2002 1:7

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  16. Content type: Methodology

    In host erythrocytes, the malaria parasite must contend with ion and drug transport across three membranes; its own plasma membrane, the parasitophorous membrane and the host plasma membrane. Isolation of pure...

    Authors: Laurence M Elandalloussi and Pete J Smith

    Citation: Malaria Journal 2002 1:6

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  17. Content type: Research

    Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria. Members of ...

    Authors: Rajinder Kumar, Brian Adams, Anja Oldenburg, Alla Musiyenko and Sailen Barik

    Citation: Malaria Journal 2002 1:5

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  18. Content type: Case report

    We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two ...

    Authors: Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst and Geoffrey Pasvol

    Citation: Malaria Journal 2002 1:1

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