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  1. Malarial anaemia is characterized by destruction of malaria infected red blood cells and suppression of erythropoiesis. Interleukin 12 (IL12) significantly boosts erythropoietic responses in murine models of m...

    Authors: Lyna Zhang, Donald Prather, Jodi Vanden Eng, Sara Crawford, Simon Kariuki, Feiko ter Kuile, Dianne Terlouw, Bernard Nahlen, Altaf A Lal, Laurence Slutsker, Venkatachalam Udhayakumar and Ya Ping Shi
    Citation: Malaria Journal 2010 9:87
    Content type: Research Published on:

  2. In the advent of increasing international collaborative research involving participants drawn from populations with diverse cultural backgrounds, community engagement becomes very critical for the smooth condu...

    Authors: Aceme Nyika, Roma Chilengi, Deus Ishengoma, Sally Mtenga, Mahamadou A Thera, Mahamadou S Sissoko, John Lusingu, Alfred B Tiono, Ogobara Doumbo, Sodiomon B Sirima, Martha Lemnge and Wen L Kilama
    Citation: Malaria Journal 2010 9:86
    Content type: Case study Published on:

  3. Plasmodium berghei ANKA infection in C57Bl/6 mice induces cerebral malaria (CM), which reproduces, to a large extent, the pathological features of human CM. However, experimental CM incidence is variable (50-100%...

    Authors: Yuri C Martins, Guilherme L Werneck, Leonardo J Carvalho, Beatriz PT Silva, Bruno G Andrade, Tadeu M Souza, Diogo O Souza and Cláudio T Daniel-Ribeiro
    Citation: Malaria Journal 2010 9:85
    Content type: Methodology Published on:

  5. The emergence of pyrethroid resistance in Anopheles gambiae has become a serious concern to the future success of malaria control. In Benin, the National Malaria Control Programme has recently planned to scaling ...

    Authors: Anges W Yadouleton, Gil Padonou, Alex Asidi, Nicolas Moiroux, Sahabi Bio-Banganna, Vincent Corbel, Raphael N'guessan, Dina Gbenou, Imorou Yacoubou, Kinde Gazard and Martin C Akogbeto
    Citation: Malaria Journal 2010 9:83
    Content type: Research Published on:

  6. Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias ...

    Authors: Michael T White, Jamie T Griffin, Chris J Drakeley and Azra C Ghani
    Citation: Malaria Journal 2010 9:82
    Content type: Research Published on:

  7. The mechanisms by which malaria up and down-regulates CYP activities are not understood yet. It is also unclear whether CYP activities are modulated during non-lethal malaria infections. This study was underta...

    Authors: Ana Cecilia AX De-Oliveira, Renato S Carvalho, Flavio HM Paixão, Hellen S Tavares, Luciana S Gueiros, Carolina M Siqueira and Francisco JR Paumgartten
    Citation: Malaria Journal 2010 9:81
    Content type: Research Published on:

  8. With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) an...

    Authors: Florence Fouque, Pascal Gaborit, Romuald Carinci, Jean Issaly and Romain Girod
    Citation: Malaria Journal 2010 9:80
    Content type: Research Published on:

  10. Several cases of malaria are frequently recorded during the dry period in Ouagadougou town (Burkina Faso). This has led to the design of a series of studies focusing on both parasitological and entomological i...

    Authors: Florence Fournet, Maud Cussac, Ali Ouari, Pierre-Erwann Meyer, Hyacinthe K Toé, Louis-Clément Gouagna and Roch K Dabiré
    Citation: Malaria Journal 2010 9:78
    Content type: Research Published on:

  11. Plasmodium falciparum merozoites expose at their surface a large protein complex, which is composed of fragments of merozoite surface protein 1 (MSP-1; called MSP-183, MSP-130, MSP-138, and MSP-142) plus associat...

    Authors: Ute Woehlbier, Christian Epp, Fiona Hackett, Michael J Blackman and Hermann Bujard
    Citation: Malaria Journal 2010 9:77
    Content type: Research Published on:

  12. The Plasmodium falciparum chimeric protein PfCP-2.9 is a promising asexual-stage malaria vaccine evaluated in clinical trials. This chimeric protein consists of two cysteine-rich domains: domain III of the apical...

    Authors: Heng Peng, Yunfei Hu, Aiguo Zhou, Changwen Jin and Weiqing Pan
    Citation: Malaria Journal 2010 9:76
    Content type: Research Published on:

  13. Analysis of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations in Plasmodium vivax wild isolates has been considered to be a valuable molecular approach for mapping resistance to sulphad...

    Authors: Sedigheh Zakeri, Mandana Afsharpad, Faezeh Ghasemi, Ahmad Raeisi, Najibullah Safi, Waqar Butt, Hoda Atta and Navid D Djadid
    Citation: Malaria Journal 2010 9:75
    Content type: Research Published on:

  14. Parasite resistance to the anti-malarial drug chloroquine is common in eastern Sudan. Dynamic within-host changes in the relative abundance of both sensitive and resistant Plasmodium falciparum parasites were exa...

    Authors: Nahla B Gadalla, Salah Eldin Elzaki, Ebtihal Mukhtar, David C Warhurst, Badria El-Sayed and Colin J Sutherland
    Citation: Malaria Journal 2010 9:74
    Content type: Research Published on:

  15. Azithromycin (AZM) is a macrolide antibiotic that displays an excellent safety profile even in children and pregnant women and has been shown to have anti-malarial activity against blood stage Plasmodium falcipar...

    Authors: Shoichi Shimizu, Yoshio Osada, Tamotsu Kanazawa, Yoshiya Tanaka and Meiji Arai
    Citation: Malaria Journal 2010 9:73
    Content type: Research Published on:

  16. Definite diagnosis of malaria relies on microscopy detection of blood stages of parasites in peripheral blood and requires blood sample collection. The nested PCR method has shown to be more sensitive and supe...

    Authors: Pattakorn Buppan, Chaturong Putaporntip, Urassaya Pattanawong, Sunee Seethamchai and Somchai Jongwutiwes
    Citation: Malaria Journal 2010 9:72
    Content type: Methodology Published on:

  17. Control of the major African malaria vector species continues to rely extensively on the application of residual insecticides through indoor house spraying or bed net impregnation. Insecticide resistance is un...

    Authors: Christophe K Kikankie, Basil D Brooke, Bart GJ Knols, Lizette L Koekemoer, Marit Farenhorst, Richard H Hunt, Matthew B Thomas and Maureen Coetzee
    Citation: Malaria Journal 2010 9:71
    Content type: Research Published on:

  18. The world is facing an increased threat from new and emerging diseases, and there is concern that climate change will expand areas suitable for transmission of vector borne diseases. The likelihood of vivax ma...

    Authors: Steven W Lindsay, David G Hole, Robert A Hutchinson, Shane A Richards and Stephen G Willis
    Citation: Malaria Journal 2010 9:70
    Content type: Research Published on:

  19. A detailed knowledge of the distribution of the main Anopheles malaria vectors in Kenya should guide national vector control strategies. However, contemporary spatial distributions of the locally dominant Anophel...

    Authors: Robi M Okara, Marianne E Sinka, Noboru Minakawa, Charles M Mbogo, Simon I Hay and Robert W Snow
    Citation: Malaria Journal 2010 9:69
    Content type: Research Published on:

  20. The development of Plasmodium falciparum resistance to chloroquine (CQ) has limited its use in many malaria endemic areas of the world. However, despite recent drug policy changes to adopt the more effective arte...

    Authors: Sabelo V Dlamini, Khalid Beshir and Colin J Sutherland
    Citation: Malaria Journal 2010 9:68
    Content type: Review Published on:

  21. Interest in indoor residual spray (IRS) has been rekindled in recent years, as it is increasingly considered to be a key component of integrated malaria management. Regular spraying of each human dwelling beco...

    Authors: Guofa Zhou, Andrew K Githeko, Noboru Minakawa and Guiyun Yan
    Citation: Malaria Journal 2010 9:67
    Content type: Research Published on:

  22. The wide use of gametocytocidal artemisinin-based combination therapy (ACT) lead to a reduction of Plasmodium falciparum transmission in several African endemic settings. An increased impact on malaria burden may...

    Authors: Leonardo Lucantoni, Rakiswendé S Yerbanga, Giulio Lupidi, Luciano Pasqualini, Fulvio Esposito and Annette Habluetzel
    Citation: Malaria Journal 2010 9:66
    Content type: Research Published on:

  23. Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competiti...

    Authors: Kiattawee Choowongkomon, Sasikrit Theppabutr, Napat Songtawee, Nicholas PJ Day, Nicholas J White, Charles J Woodrow and Mallika Imwong
    Citation: Malaria Journal 2010 9:65
    Content type: Research Published on:

  24. Infection with Plasmodium is the cause of malaria, a disease characterized by a high inflammatory response in the blood. Dendritic cells (DC) participate in both adaptive and innate immune responses, influencing ...

    Authors: Esther Bettiol, Daniel Carapau, Cristina Galan-Rodriguez, Carlos Ocaña-Morgner and Ana Rodriguez
    Citation: Malaria Journal 2010 9:64
    Content type: Research Published on:

  25. Although malaria in pregnancy can cause very significant neonatal morbidity, congenital malaria is a very rare condition in both endemic and non-endemic areas. A case of congenital malaria by Plasmodium vivax, in...

    Authors: Veronica Del Punta, Maurizio Gulletta, Alberto Matteelli, Vania Spinoni, Antonio Regazzoli and Francesco Castelli
    Citation: Malaria Journal 2010 9:63
    Content type: Case report Published on:

  26. High coverage of insecticide-treated bed nets in Asembo and low coverage in Seme, two adjacent communities in western Nyanza Province, Kenya; followed by expanded coverage of bed nets in Seme, as the Kenya nat...

    Authors: M Nabie Bayoh, Derrick K Mathias, Maurice R Odiere, Francis M Mutuku, Luna Kamau, John E Gimnig, John M Vulule, William A Hawley, Mary J Hamel and Edward D Walker
    Citation: Malaria Journal 2010 9:62
    Content type: Research Published on:

  27. New malaria treatment guidelines in Tanzania have led to the large-scale deployment of artemether-lumefantrine (Coartem®), popularly known as ALu or dawa mseto. Very little is known about how people in malaria en...

    Authors: Vinay R Kamat and Daniel J Nyato
    Citation: Malaria Journal 2010 9:61
    Content type: Research Published on:

  29. Accurate information on the geographical distribution of malaria is important for efficient resource allocation. The Lao People's Democratic Republic has experienced a major decline in malaria morbidity and mo...

    Authors: Pernille Jorgensen, Simone Nambanya, Deyer Gopinath, Bouasy Hongvanthong, Kongxay Luangphengsouk, David Bell, Samlane Phompida and Rattanaxay Phetsouvanh
    Citation: Malaria Journal 2010 9:59
    Content type: Research Published on:

  30. In 2005, a nationwide survey estimated that 6.5% of households in Ethiopia owned an insecticide-treated net (ITN), 17% of households had been sprayed with insecticide, and 4% of children under five years of ag...

    Authors: Daddi Jima, Asefaw Getachew, Hana Bilak, Richard W Steketee, Paul M Emerson, Patricia M Graves, Teshome Gebre, Richard Reithinger and Jimee Hwang
    Citation: Malaria Journal 2010 9:58
    Content type: Research Published on:

  31. Previous efforts to eradicate malaria parasites, particularly Plasmodium falciparum, have failed in part due to the emergence of drug resistant parasites and mosquitoes resistant to insecticides. Using an artemis...

    Authors: Jianping Song, Duong Socheat, Bo Tan, Prak Dara, Changsheng Deng, Sreng Sokunthea, Suon Seila, Fengzhen Ou, Huaxiang Jian and Guoqiao Li
    Citation: Malaria Journal 2010 9:57
    Content type: Research Published on:

  32. The use of drug combinations, including non-artemisinin-based and artemisinin-based combination therapy (ACT), is a novel strategy that enhances therapeutic efficacy and delays the emergence of multidrug-resis...

    Authors: Solange Youdom Whegang, Rachida Tahar, Vincent Ngane Foumane, Georges Soula, Henri Gwét, Jean-Christophe Thalabard and Leonardo K Basco
    Citation: Malaria Journal 2010 9:56
    Content type: Research Published on:

  33. Larval mosquito habitats of potential malaria vectors and related species of Anopheles from three provinces (Gyeonggi, Gyeongsangbuk, Chungcheongbuk Provinces) of the Republic of Korea were surveyed in 2007. This...

    Authors: Leopoldo M Rueda, Tracy L Brown, Heung Chul Kim, Sung-Tae Chong, Terry A Klein, Desmond H Foley, Assaf Anyamba, Matthew Smith, Edwin P Pak and Richard C Wilkerson
    Citation: Malaria Journal 2010 9:55
    Content type: Research Published on:

  34. The Tanzanian government recommends women who attend antenatal care (ANC) clinics to accept receiving intermittent preventive treatment against malaria during pregnancy (IPTp) and vouchers for insecticide-trea...

    Authors: Godfrey M Mubyazi, Paul Bloch, Pascal Magnussen, Øystein E Olsen, Jens Byskov, Kristian S Hansen and Ib C Bygbjerg
    Citation: Malaria Journal 2010 9:54
    Content type: Research Published on:

  35. Drug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of t...

    Authors: Akintunde Sowunmi, Elsie O Adewoye, Grace O Gbotsho, Christian T Happi, Abayomi Sijuade, Onikepe A Folarin, Titilope M Okuboyejo and Obaro S Michael
    Citation: Malaria Journal 2010 9:53
    Content type: Research Published on:

  36. Chloroquine was used as first-line treatment for Plasmodium falciparum or Plasmodium vivax in Indonesia before the initial launch of artemisinin combination therapy in 2004. A study to evaluate efficacies of chlo...

    Authors: Inge Sutanto, Dedeh Endawati, Liem Hui Ling, Ferdinand Laihad, Rianto Setiabudy and J Kevin Baird
    Citation: Malaria Journal 2010 9:52
    Content type: Research Published on:

  37. The clinical utility for mefloquine has been eroded due to its association with adverse neurological effects. Better-tolerated alternatives are required. The objective of the present study was the identificati...

    Authors: Erin Milner, William McCalmont, Jayendra Bhonsle, Diana Caridha, Jose Cobar, Sean Gardner, Lucia Gerena, Duane Goodine, Charlotte Lanteri, Victor Melendez, Norma Roncal, Jason Sousa, Peter Wipf and Geoffrey Stuart Dow
    Citation: Malaria Journal 2010 9:51
    Content type: Research Published on:

  38. In many low-income countries, the retail sector plays an important role in the treatment of malaria and is increasingly being considered as a channel for improving medicine availability. Retailers are the last...

    Authors: Edith Patouillard, Kara G Hanson and Catherine A Goodman
    Citation: Malaria Journal 2010 9:50
    Content type: Research Published on:

  39. The activity of promising anti-malarial drugs against Plasmodium gametocytes is hard to evaluate even in vitro. This is because visual examination of stained smears, which is commonly used, is not totally conveni...

    Authors: Séverine Chevalley, Agnès Coste, Alexandrine Lopez, Bernard Pipy and Alexis Valentin
    Citation: Malaria Journal 2010 9:49
    Content type: Methodology Published on:

  40. Controlled clinical trials have shown that a six-dose regimen of artemether-lumefantrine (AL) therapy for uncomplicated Plasmodium falciparum malaria results in cure rates >95% with good tolerability.

    Authors: Abdunoor M Kabanywanyi, Christian Lengeler, Prudensiana Kasim, Said King'eng'ena, Raymond Schlienger, Nathan Mulure and Blaise Genton
    Citation: Malaria Journal 2010 9:48
    Content type: Research Published on:

  41. Malaria remains the most important public health problem in tropical and subtropical areas. Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes a...

    Authors: Delenasaw Yewhalaw, Wondwossen Kassahun, Kifle Woldemichael, Kora Tushune, Morankar Sudaker, Daniel Kaba, Luc Duchateau, Wim Van Bortel and Niko Speybroeck
    Citation: Malaria Journal 2010 9:47
    Content type: Research Published on:

  42. The merozoite surface protein (MSP)-1 is a target antigen of protective immunity and a malaria vaccine candidate. The nature of this protective immune response warrants further investigation: although specific...

    Authors: Irosoki Eslava, Gilberto Payares, Beatriz M Pernia, Anthony A Holder and Lilian M Spencer
    Citation: Malaria Journal 2010 9:46
    Content type: Research Published on:

  43. Placental malaria (PM) is associated with poor foetal development, but the pathophysiological processes involved are poorly understood. Cyclooxygenase (COX) and lipoxygenase (LOX) which convert fatty acids to ...

    Authors: Demba Sarr, Delphine Aldebert, Laurence Marrama, Emilie Frealle, Alioune Gaye, Hamoud O Brahim, Makhtar Niang, Jean Marie Dangou, Odile Mercereau-Puijalon, Jean Yves Lehesran and Ronan Jambou
    Citation: Malaria Journal 2010 9:45
    Content type: Research Published on:

  44. Scaling up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) with support from the Global Fund and President's Malaria Initiative is providing increased opportunities for malaria con...

    Authors: Raphael N'Guessan, Pelagie Boko, Abibathou Odjo, Joseph Chabi, Martin Akogbeto and Mark Rowland
    Citation: Malaria Journal 2010 9:44
    Content type: Research Published on:

  45. Artemisinin-based combination therapy (ACT) is presently recommended by the World Health Organization as first-line treatment for uncomplicated Plasmodium falciparum malaria in several countries, as a mean of pro...

    Authors: Kanungnit Congpuong, Pongwit Bualombai, Vick Banmairuroi and Kesara Na-Bangchang
    Citation: Malaria Journal 2010 9:43
    Content type: Research Published on:

  46. There have been a number of interventions to date aimed at improving malaria diagnostic accuracy in sub-Saharan Africa. Yet, limited success is often reported for a number of reasons, especially in rural setti...

    Authors: Lisa K Allen, Erin Hetherington, Mange Manyama, Jennifer M Hatfield and Guido van Marle
    Citation: Malaria Journal 2010 9:42
    Content type: Case study Published on:

  47. The effectiveness of malaria chemoprophylaxis is limited by the lack of compliance whose determinants are not well known.

    Authors: Noémie Resseguier, Vanessa Machault, Lénaick Ollivier, Eve Orlandi-Pradines, Gaetan Texier, Bruno Pradines, Jean Gaudart, Alain Buguet, Catherine Tourette-Turgis and Christophe Rogier
    Citation: Malaria Journal 2010 9:41
    Content type: Research Published on:

  48. The island of Timor lies at the south-eastern edge of Indonesia on the boundary of the Oriental and Australian faunal regions. The country of Timor-Leste, which occupies the eastern part of the island, is mala...

    Authors: Robert D Cooper, Michael D Edstein, Stephen P Frances and Nigel W Beebe
    Citation: Malaria Journal 2010 9:40
    Content type: Research Published on:

  49. A moderate association has been found between asymptomatic parasitaemia and undernutrition. However, additional investigation using the gold standard for asymptomatic parasitaemia confirmation, polymerase chai...

    Authors: Benjamin T Crookston, Stephen C Alder, Isaac Boakye, Ray M Merrill, John H Amuasi, Christina A Porucznik, Joseph B Stanford, Ty T Dickerson, Kirk A Dearden, DeVon C Hale, Justice Sylverken, Bryce S Snow, Alex Osei-Akoto and Daniel Ansong
    Citation: Malaria Journal 2010 9:39
    Content type: Research Published on:

  50. Highly purified infected red blood cells (irbc), or highly synchronized parasite cultures, are regularly required in malaria research. Conventional isolation and synchronization rely on density and osmotic fra...

    Authors: Sebastian C Bhakdi, Annette Ottinger, Sangdao Somsri, Panudda Sratongno, Peeranad Pannadaporn, Pattamawan Chimma, Prida Malasit, Kovit Pattanapanyasat and Hartmut PH Neumann
    Citation: Malaria Journal 2010 9:38
    Content type: Methodology Published on:
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Malaria Journal

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