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  1. Malaria in pregnancy is characterized by accumulation of infected erythrocytes (IE) in the placenta. The key ligand identified as mediating this process is a Plasmodium falciparum erythrocyte membrane protein 1 f...

    Authors: Francisca Yosaatmadja, Katherine T Andrews, Michael F Duffy, Graham V Brown, James G Beeson and Stephen J Rogerson

    Citation: Malaria Journal 2008 7:51

    Content type: Research

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  2. In the rural areas of sub-Saharan Africa, the majority of young children affected by malaria have no access to formal health services. Home treatment through mothers of febrile children supported by mother gro...

    Authors: Bocar Kouyaté, Florent Somé, Albrecht Jahn, Boubacar Coulibaly, Jaran Eriksen, Rainer Sauerborn, Lars Gustafsson, Göran Tomson, Heiko Becher and Olaf Mueller

    Citation: Malaria Journal 2008 7:50

    Content type: Research

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  3. In order to evaluate whether criteria for LLIN field performance (phase III) set by the WHO Pesticide Evaluation Scheme are met, first and second generations of one of these products, PermaNet®, a polyester net u...

    Authors: Albert Kilian, Wilson Byamukama, Olivier Pigeon, Francis Atieli, Stephan Duchon and Chi Phan

    Citation: Malaria Journal 2008 7:49

    Content type: Research

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  4. Sulphadoxine-pyrimethamine has been abandoned as first- or second-line treatment by most African malaria endemic countries in favour of artemisinin-based combination treatments, but the drug is still used as i...

    Authors: Petra F Mens, Chantal van Overmeir, Maryline Bonnet, Jean-Claude Dujardin and Umberto d'Alessandro

    Citation: Malaria Journal 2008 7:48

    Content type: Methodology

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  5. The transcriptional regulation of Plasmodium during its complex life cycle requires sequential activation and/or repression of different genetic programmes. MicroRNAs (miRNAs) are a highly conserved class of non-...

    Authors: Xiangyang Xue, Qingfeng Zhang, Yufu Huang, Le Feng and Weiqing Pan

    Citation: Malaria Journal 2008 7:47

    Content type: Research

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  6. Segmental duplications (SD) have been found in genomes of various organisms, often accumulated at the ends of chromosomes. It has been assumed that the sequence homology in-between the SDs allow for ectopic in...

    Authors: Bobo W Mok, Ulf Ribacke, Ellen Sherwood and Mats Wahlgren

    Citation: Malaria Journal 2008 7:46

    Content type: Research

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  7. Parasite concentration methods facilitate molecular, biochemical and immunological research on the erythrocytic stages of Plasmodium. In this paper, an adaptation of magnetic MACS® columns for the purification of...

    Authors: Clotilde Ribaut, Antoine Berry, Séverine Chevalley, Karine Reybier, Isabelle Morlais, Daniel Parzy, Françoise Nepveu, Françoise Benoit-Vical and Alexis Valentin

    Citation: Malaria Journal 2008 7:45

    Content type: Methodology

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  8. To reduce the intolerable burden of malaria in pregnancy, the Ministry of Health in Uganda improved the antenatal care package by including a strong commitment to increase distribution of insecticide-treated n...

    Authors: Mpungu S Kiwuwa and Patrobas Mufubenga

    Citation: Malaria Journal 2008 7:44

    Content type: Research

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  9. Studies were conducted between April 2004 and February 2006 to determine the blood-feeding pattern of Anopheles mosquitoes in Mwea Kenya.

    Authors: Simon M Muriu, Ephantus J Muturi, Josephat I Shililu, Charles M Mbogo, Joseph M Mwangangi, Benjamin G Jacob, Lucy W Irungu, Richard W Mukabana, John I Githure and Robert J Novak

    Citation: Malaria Journal 2008 7:43

    Content type: Research

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  10. In Plasmodium falciparum-infected children, the relationships between blood cell histopathology, blood plasma components, development of immunocompetence and disease severity remain poorly understood. Blood from ...

    Authors: Virginia S Baker, Godwin E Imade, Norman B Molta, Pallavi Tawde, Sunday D Pam, Michael O Obadofin, Soloman A Sagay, Daniel Z Egah, Daniel Iya, Bangmboye B Afolabi, Murray Baker, Karen Ford, Robert Ford, Kenneth H Roux and Thomas CS Keller III

    Citation: Malaria Journal 2008 7:41

    Content type: Research

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  11. Transmission of Plasmodium falciparum generally decreases with increasing elevation, in part because lower temperature slows the development of both parasites and mosquitoes. However, other aspects of the terrain...

    Authors: Justin M Cohen, Kacey C Ernst, Kim A Lindblade, John M Vulule, Chandy C John and Mark L Wilson

    Citation: Malaria Journal 2008 7:40

    Content type: Research

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  12. Urban malaria is likely to become increasingly important as a consequence of the growing proportion of Africans living in cities. A novel sampling strategy was developed for urban areas to generate a sample si...

    Authors: Jose G Siri, Kim A Lindblade, Daniel H Rosen, Bernard Onyango, John M Vulule, Laurence Slutsker and Mark L Wilson

    Citation: Malaria Journal 2008 7:39

    Content type: Research

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  13. Long-lasting insecticidal nets (LLINs) are advocated by WHO for protection against malaria. Of the three brands of LLINs currently approved by WHO, Olyset® is the only one currently granted full recommendation. W...

    Authors: Robert C Malima, Stephen M Magesa, Patrick K Tungu, Victor Mwingira, Frank S Magogo, Wema Sudi, Frank W Mosha, Christopher F Curtis, Caroline Maxwell and Mark Rowland

    Citation: Malaria Journal 2008 7:38

    Content type: Research

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  14. Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the ...

    Authors: Quique Bassat, Caterina Guinovart, Betuel Sigaúque, Pedro Aide, Jahit Sacarlal, Tacilta Nhampossa, Azucena Bardají, Ariel Nhacolo, Eusébio Macete, Inácio Mandomando, John J Aponte, Clara Menéndez and Pedro L Alonso

    Citation: Malaria Journal 2008 7:37

    Content type: Research

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  15. Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentat...

    Authors: Caterina Guinovart, Quique Bassat, Betuel Sigaúque, Pedro Aide, Jahit Sacarlal, Tacilta Nhampossa, Azucena Bardají, Ariel Nhacolo, Eusébio Macete, Inácio Mandomando, John J Aponte, Clara Menéndez and Pedro L Alonso

    Citation: Malaria Journal 2008 7:36

    Content type: Research

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  16. Four of five Plasmodium species infecting humans are present in Madagascar. Plasmodium vivax remains the second most prevalent species, but is understudied. No data is available on its susceptibility to sulphadox...

    Authors: Céline Barnadas, Magali Tichit, Christiane Bouchier, Arsène Ratsimbasoa, Laurence Randrianasolo, Rogelin Raherinjafy, Martial Jahevitra, Stéphane Picot and Didier Ménard

    Citation: Malaria Journal 2008 7:35

    Content type: Research

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  17. Although sub-Saharan Africa (SSA) is rapidly urbanizing, the terms used to classify urban ecotypes are poorly defined in the context of malaria epidemiology. Lack of clear definitions may cause misclassificati...

    Authors: Jose G Siri, Kim A Lindblade, Daniel H Rosen, Bernard Onyango, John Vulule, Laurence Slutsker and Mark L Wilson

    Citation: Malaria Journal 2008 7:34

    Content type: Methodology

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  18. It is estimated that over 70% of patients with suspected malaria in sub-Saharan Africa, diagnose and manage their illness at home without referral to a formal health clinic. Of those patients who do attend a f...

    Authors: Jen CC Hume, Guy Barnish, Tara Mangal, Luiz Armázio, Elizabeth Streat and Imelda Bates

    Citation: Malaria Journal 2008 7:33

    Content type: Research

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  19. In Gabon, following the adoption of amodiaquine/artesunate combination (AQ/AS) as first-line treatment of malaria and of sulphadoxine/pyrimethamine (SP) for preventive intermittent treatment of pregnant women,...

    Authors: Basile Nsimba, Vincent Guiyedi, Modeste Mabika-Mamfoumbi, Jean Romain Mourou-Mbina, Edgard Ngoungou, Marielle Bouyou-Akotet, Romaric Loembet, Rémy Durand, Jacques Le Bras and Maryvonne Kombila

    Citation: Malaria Journal 2008 7:31

    Content type: Research

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  20. Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention w...

    Authors: Beatrice Wasunna, Dejan Zurovac, Catherine A Goodman and Robert W Snow

    Citation: Malaria Journal 2008 7:29

    Content type: Research

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  21. In Central Vietnam, forest malaria remains difficult to control due to the complex interactions between human, vector and environmental factors.

    Authors: Ngo Duc Thang, Annette Erhart, Niko Speybroeck, Le Xuan Hung, Le Khanh Thuan, Cong Trinh Hung, Pham Van Ky, Marc Coosemans and Umberto D'Alessandro

    Citation: Malaria Journal 2008 7:28

    Content type: Research

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  22. There is a widespread notion, based on limited information, that in areas of stable malaria transmission most pregnant women with Plasmodium falciparum infection are asymptomatic. This study aim to characterize t...

    Authors: Azucena Bardají, Betuel Sigauque, Laia Bruni, Cleofé Romagosa, Sergi Sanz, Samuel Mabunda, Inacio Mandomando, John Aponte, Esperança Sevene, Pedro L Alonso and Clara Menéndez

    Citation: Malaria Journal 2008 7:27

    Content type: Research

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  23. Placental malaria (PM) is an important cause of maternal and foetal mortality in tropical areas, and severe sequelae and mortality are related to inflammation in the placenta. Diagnosis is difficult because PM...

    Authors: Edward R Kabyemela, Atis Muehlenbachs, Michal Fried, Jonathan D Kurtis, Theonest K Mutabingwa and Patrick E Duffy

    Citation: Malaria Journal 2008 7:26

    Content type: Research

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  24. Following the recognition that morbidity and mortality due to malaria had dramatically increased in the last three decades, in 2002 the government of Zambia reviewed its efforts to prevent and treat malaria. C...

    Authors: Naawa Sipilanyambe, Jonathon L Simon, Pascalina Chanda, Peter Olumese, Robert W Snow and Davidson H Hamer

    Citation: Malaria Journal 2008 7:25

    Content type: Case study

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  25. Many Nigerian children with malaria are treated at home. Treatments are mostly incorrect, due to caregivers' poor knowledge of appropriate and correct dose of drugs. A comparative study was carried out in two ...

    Authors: Ikeoluwapo O Ajayi, Catherine O Falade, E Afolabi Bamgboye, Ayo MJ Oduola and Oladele O Kale

    Citation: Malaria Journal 2008 7:24

    Content type: Research

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  26. The emergence of Plasmodium falciparum resistant to most currently used antimalarial drugs is the major problem in malaria control along the Thai-Myanmar and Thai-Cambodia borders. Although artemisinin-based comb...

    Authors: Rommanee Khositnithikul, Peerapan Tan-ariya and Mathirut Mungthin

    Citation: Malaria Journal 2008 7:23

    Content type: Research

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  27. Malaria microscopy remains the reference standard for malaria diagnosis in clinical trials (drug and vaccine), new diagnostic evaluation, as well as in clinical care in much of the world today. It is known tha...

    Authors: Colin Ohrt, Wendy Prudhomme O'Meara, Shon Remich, Peter McEvoy, Bernhards Ogutu, Ramadan Mtalib and James Sande Odera

    Citation: Malaria Journal 2008 7:22

    Content type: Research

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  28. Rapid diagnostic tests (RDTs) for malaria are increasingly being considered for routine use in Africa. However, many RDTs are available and selecting the ideal test for a particular setting is challenging. The...

    Authors: Yoel Lubell, Heidi Hopkins, Christopher JM Whitty, Sarah G Staedke and Anne Mills

    Citation: Malaria Journal 2008 7:21

    Content type: Research

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  29. As the population of Africa rapidly urbanizes, large populations could be protected from malaria by controlling aquatic stages of mosquitoes if cost-effective and scalable implementation systems can be designed.

    Authors: Ulrike Fillinger, Khadija Kannady, George William, Michael J Vanek, Stefan Dongus, Dickson Nyika, Yvonne Geissbühler, Prosper P Chaki, Nico J Govella, Evan M Mathenge, Burton H Singer, Hassan Mshinda, Steven W Lindsay, Marcel Tanner, Deo Mtasiwa, Marcia C de Castro…

    Citation: Malaria Journal 2008 7:20

    Content type: Methodology

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  30. The human malaria parasite Plasmodium falciparum exploits antigenic diversity and within-host antigenic variation to evade the host's immune system. Of particular importance are the highly polymorphic var genes t...

    Authors: Mario Recker, Nimalan Arinaminpathy and Caroline O Buckee

    Citation: Malaria Journal 2008 7:18

    Content type: Research

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  31. Individuals living in malaria endemic areas generally harbour multiple parasite strains. Multiplicity of infection (MOI) can be an indicator of immune status. However, whether this is good or bad for the devel...

    Authors: Manijeh Vafa, Marita Troye-Blomberg, Judith Anchang, André Garcia and Florence Migot-Nabias

    Citation: Malaria Journal 2008 7:17

    Content type: Research

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  32. Artesunate plus amodiaquine is a coblistered ACT, given as a single daily intake. It has been suggested that, in view of the number of tablets to be taken (particularly in adults), it may be possible to improv...

    Authors: Jean Louis A Ndiaye, Babacar Faye, Amadou M Diouf, Thomas Kuété, Moustapha Cisse, Papa A Seck, Phillipe Brasseur, Albert Same-Ekobo, Valerie Lameyre and Oumar Gaye

    Citation: Malaria Journal 2008 7:16

    Content type: Research

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  33. Malaria is a leading cause of death in children below five years of age in sub-Saharan Africa. All-cause and malaria-specific mortality rates for children under-five years old in a mesoendemic malaria area (Th...

    Authors: Robert P Ndugwa, Heribert Ramroth, Olaf Müller, Momodou Jasseh, Ali Sié, Bocar Kouyaté, Brian Greenwood and Heiko Becher

    Citation: Malaria Journal 2008 7:15

    Content type: Review

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  34. Cytoadherence of Plasmodium falciparum-infected red blood cells is mediated by var gene-encoded P. falciparum erythrocyte membrane protein-1 and host receptor preference depends in most cases on which of the 50–6...

    Authors: Uta Gölnitz, Letusa Albrecht and Gerhard Wunderlich

    Citation: Malaria Journal 2008 7:14

    Content type: Methodology

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  35. Susceptibility/resistance to Plasmodium falciparum malaria has been correlated with polymorphisms in more than 30 human genes with most association analyses having been carried out on patients from Africa and sou...

    Authors: Swapnil Sinha, Shrawan K Mishra, Shweta Sharma, Phani K Patibandla, Prashant K Mallick, Surya K Sharma, Sanjib Mohanty, Sudhanshu S Pati, Saroj K Mishra, Bheshaj K Ramteke, RM Bhatt, Hema Joshi, Aditya P Dash, Ramesh C Ahuja, Shally Awasthi, Vimala Venkatesh…

    Citation: Malaria Journal 2008 7:13

    Content type: Research

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  36. The distribution of anopheline mosquitoes in Vietnam was examined, with a particular interest for the two sibling species of the Anopheles minimus complex (Cellia: Myzomyia), An. minimus and Anopheles harrisoni, ...

    Authors: Claire Garros, Cam Van Nguyen, Ho Dinh Trung, Wim Van Bortel, Marc Coosemans and Sylvie Manguin

    Citation: Malaria Journal 2008 7:11

    Content type: Research

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  37. Pregnant women develop protective anti-VSA IgG1 and IgG3 when infected by Plasmodium falciparum. The major target of IgG from serum of infected pregnant women is VAR2CSA.

    Authors: Juliette Guitard, Gilles Cottrell, Nellie Moulopo Magnouha, Ali Salanti, Tengfei Li, Sokhna Sow, Philippe Deloron and Nicaise Tuikue Ndam

    Citation: Malaria Journal 2008 7:10

    Content type: Research

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  38. The Kilombero Valley is a highly malaria-endemic agricultural area in south-eastern Tanzania. Seasonal flooding of the valley is favourable to malaria transmission. During the farming season, many households m...

    Authors: Manuel W Hetzel, Sandra Alba, Mariette Fankhauser, Iddy Mayumana, Christian Lengeler, Brigit Obrist, Rose Nathan, Ahmed M Makemba, Christopher Mshana, Alexander Schulze and Hassan Mshinda

    Citation: Malaria Journal 2008 7:7

    Content type: Research

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  39. The Home Management of Malaria (HMM) strategy was developed using chloroquine, a now obsolete drug, which has been replaced by artemisinin-based combination therapy (ACT) in health facility settings. Incorpora...

    Authors: Ikeoluwapo O Ajayi, Edmund N Browne, Bertha Garshong, Fred Bateganya, Bidemi Yusuf, Peter Agyei-Baffour, Leticia Doamekpor, Andrew Balyeku, Kaendi Munguti, Simon Cousens and Franco Pagnoni

    Citation: Malaria Journal 2008 7:6

    Content type: Research

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  40. Equitable improvement of treatment-seeking for malaria will depend partly on how different socio-economic groups perceive the ease of accessing and utilizing malaria treatment services from different healthcar...

    Authors: Obinna Onwujekwe, Benjamin Uzochukwu, Soludo Eze, Eric Obikeze, Chijioke Okoli and Ogbonnia Ochonma

    Citation: Malaria Journal 2008 7:5

    Content type: Research

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  41. The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT). However, little evidence is available on the full costs associat...

    Authors: Joseph D Njau, Catherine A Goodman, S Patrick Kachur, Jo Mulligan, John S Munkondya, Naiman Mchomvu, Salim Abdulla, Peter Bloland and Anne Mills

    Citation: Malaria Journal 2008 7:4

    Content type: Case study

    Published on:

  42. Cerebral malaria (CM) is an acute encephalopathy with increased pro-inflammatory cytokines, sequestration of parasitized erythrocytes and localized ischaemia. In children CM induces cognitive impairment in abo...

    Authors: Lothar Wiese, Casper Hempel, Milena Penkowa, Nikolai Kirkby and Jørgen AL Kurtzhals

    Citation: Malaria Journal 2008 7:3

    Content type: Research

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  43. In the pre-intervention year of a randomized controlled trial investigating the protective effects of house screening against malaria-transmitting vectors, a multi-factorial risk factor analysis study was used...

    Authors: Matthew J Kirby, Clare Green, Paul M Milligan, Charalambos Sismanidis, Momadou Jasseh, David J Conway and Steven W Lindsay

    Citation: Malaria Journal 2008 7:2

    Content type: Research

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