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  1. Effective case management is central to reducing malaria mortality and morbidity worldwide, but only a minority of those affected by malaria, have access to prompt effective treatment.

    Authors: Jane Chuma, Timothy Abuya, Dorothy Memusi, Elizabeth Juma, Willis Akhwale, Janet Ntwiga, Andrew Nyandigisi, Gladys Tetteh, Rima Shretta and Abdinasir Amin
    Citation: Malaria Journal 2009 8:243
  2. In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehy...

    Authors: Elizabeth A Ashley, Malek Touabi, Margareta Ahrer, Robert Hutagalung, Khayae Htun, Jennifer Luchavez, Christine Dureza, Stephane Proux, Mara Leimanis, Myo Min Lwin, Alena Koscalova, Eric Comte, Prudence Hamade, Anne-Laure Page, François Nosten and Philippe J Guerin
    Citation: Malaria Journal 2009 8:241
  3. Previous studies of Anopheles funestus chromosomal inversion polymorphisms in Burkina Faso showed large departures from Hardy-Weinberg equilibrium and linkage disequilibrium among inversions located on different ...

    Authors: Wamdaogo M Guelbeogo, N'Fale Sagnon, Olga Grushko, Malgaouende A Yameogo, Daniela Boccolini, Nora J Besansky and Carlo Costantini
    Citation: Malaria Journal 2009 8:239
  4. Artesunate plus sulphadoxine-pyrimethamine is one of the four artemisinin-based combination therapies currently recommended by WHO as first-line treatment for falciparum malaria. Sulphadoxine-pyrimethamine is ...

    Authors: Grace O Gbotosho, Christian T Happi, Abayomi O Sijuade, Akin Sowunmi and Ayoade MJ Oduola
    Citation: Malaria Journal 2009 8:238
  5. Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presump...

    Authors: Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa and James K Tumwine
    Citation: Malaria Journal 2009 8:237
  6. Malaria chemoprophylaxis compliance is suboptimal among French soldiers despite the availability of free malaria chemoprophylaxis and repeated health education before, during and after deployment to malaria en...

    Authors: Lénaïck Ollivier, Olivier Romand, Catherine Marimoutou, Rémy Michel, Corinne Pognant, Alain Todesco, René Migliani, Dominique Baudon and Jean-Paul Boutin
    Citation: Malaria Journal 2009 8:236
  7. MB2 protein is a sporozoite surface antigen on the human malaria parasite Plasmodium falciparum. MB2 was identified by screening a P. falciparum sporozoite cDNA expression library using immune sera from a protect...

    Authors: Thanh V Nguyen, John B Sacci Jr, Patricia de la Vega, Chandy C John, Anthony A James and Angray S Kang
    Citation: Malaria Journal 2009 8:235
  8. Although the occurrence of malaria vector larvae in the valleys of western Kenya highlands is well documented, knowledge of larval habitats in the uphill sites is lacking. Given that most inhabitants of the hi...

    Authors: Yousif E Himeidan, Guofa Zhou, Laith Yakob, Yaw Afrane, Stephen Munga, Harrysone Atieli, El-Amin El-Rayah, Andrew K Githeko and Guiyun Yan
    Citation: Malaria Journal 2009 8:234
  9. Pyrethroid resistance is now widespread in Anopheles gambiae, the major vector for malaria in sub-Saharan Africa. This resistance may compromise malaria vector control strategies that are currently in use in ende...

    Authors: Armel Djènontin, Joseph Chabi, Thierry Baldet, Seth Irish, Cédric Pennetier, Jean-Marc Hougard, Vincent Corbel, Martin Akogbéto and Fabrice Chandre
    Citation: Malaria Journal 2009 8:233
  10. It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the presen...

    Authors: Izumi Naka, Nao Nishida, Jintana Patarapotikul, Pornlada Nuchnoi, Katsushi Tokunaga, Hathairad Hananantachai, Naoyuki Tsuchiya and Jun Ohashi
    Citation: Malaria Journal 2009 8:232
  11. Approximately 40% of the world's population is at risk for malaria. In highly endemic tropical areas, malaria is a major cause of morbidity and mortality during infancy. There is a complex interrelationship be...

    Authors: Sheila Vitor-Silva, Roberto C Reyes-Lecca, Tamam RA Pinheiro and Marcus VG Lacerda
    Citation: Malaria Journal 2009 8:230
  12. A number of molecular tools have been developed to monitor the emergence and spread of anti-malarial drug resistance to Plasmodium falciparum. One of the major obstacles to the wider implementation of these tools...

    Authors: Nicolas Steenkeste, Marie-Agnès Dillies, Nimol Khim, Odile Sismeiro, Sophy Chy, Pharath Lim, Andreas Crameri, Christiane Bouchier, Odile Mercereau-Puijalon, Hans-Peter Beck, Mallika Imwong, Arjen M Dondorp, Duong Socheat, Christophe Rogier, Jean-Yves Coppée and Frédéric Ariey
    Citation: Malaria Journal 2009 8:229
  13. Daily mortality is an important determinant of a vector's ability to transmit pathogens. Original simplifying assumptions in malaria transmission models presume vector mortality is independent of age, infectio...

    Authors: Emma J Dawes, Thomas S Churcher, Shijie Zhuang, Robert E Sinden and María-Gloria Basáñez
    Citation: Malaria Journal 2009 8:228
  14. This study describes patterns of falciparum and vivax malaria in a private comprehensive-care, multi-specialty hospital in New Delhi from July 2006 to July 2008.

    Authors: Sangeeta Gupta, James T Gunter, Robert J Novak and James L Regens
    Citation: Malaria Journal 2009 8:227
  15. The standard in vitro test to assess anti-malarial activity of chemical compounds is the [3H]hypoxanthine incorporation assay. It is a radioactivity-based method to measure DNA replication of Plasmodium in red bl...

    Authors: Lucienne Tritten, Hugues Matile, Reto Brun and Sergio Wittlin
    Citation: Malaria Journal 2009 8:226
  16. Malaria is one of the most significant causes of morbidity and mortality worldwide. Every year, nearly one million deaths result from malaria infection. Malaria can be controlled in endemic countries by using ...

    Authors: Karen I Barnes, Pascalina Chanda and Gebre Ab Barnabas
    Citation: Malaria Journal 2009 8(Suppl 1):S8

    This article is part of a Supplement: Volume 8 Supplement 1

  17. Infants and children under five years of age are the most vulnerable to malaria with over 1,700 deaths per day from malaria in this group. However, until recently, there were no WHO-endorsed paediatric anti-ma...

    Authors: Salim Abdulla and Issaka Sagara
    Citation: Malaria Journal 2009 8(Suppl 1):S7

    This article is part of a Supplement: Volume 8 Supplement 1

  18. This article reviews the comprehensive data on the safety and tolerability from over 6,300 patients who have taken artemether/lumefantrine (Coartem®) as part of Novartis-sponsored or independently-sponsored clini...

    Authors: Catherine Falade and Christine Manyando
    Citation: Malaria Journal 2009 8(Suppl 1):S6

    This article is part of a Supplement: Volume 8 Supplement 1

  19. Current World Health Organization (WHO) guidelines for the treatment of uncomplicated falciparum malaria recommend the use of artemisinin-based combination therapy (ACT). Artemether/lumefantrine is an ACT preq...

    Authors: Michael Makanga and Srivicha Krudsood
    Citation: Malaria Journal 2009 8(Suppl 1):S5

    This article is part of a Supplement: Volume 8 Supplement 1

  20. Artemether and lumefantrine (AL), the active constituents of Coartem® exhibit complementary pharmacokinetic profiles. Artemether is absorbed quickly; peak concentrations of artemether and its main active metaboli...

    Authors: Abdoulaye Djimdé and Gilbert Lefèvre
    Citation: Malaria Journal 2009 8(Suppl 1):S4

    This article is part of a Supplement: Volume 8 Supplement 1

  21. Artemisinin, from which the artemether component of Coartem®(artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chin...

    Authors: Zulfiqarali G Premji
    Citation: Malaria Journal 2009 8(Suppl 1):S3

    This article is part of a Supplement: Volume 8 Supplement 1

  22. Malaria has traditionally been a major endemic disease in Equatorial Guinea. Although parasitaemia prevalence on the insular region has been substantially reduced by vector control in the past few years, the p...

    Authors: Estefanía Custodio, Miguel Ángel Descalzo, Eduardo Villamor, Laura Molina, Ignacio Sánchez, Magdalena Lwanga, Cristina Bernis, Agustín Benito and Jesús Roche
    Citation: Malaria Journal 2009 8:225
  23. The weekly chemoprophylaxis of malaria during pregnancy with chloroquine (CQ) has become problematic with the increasing resistance of Plasmodium falciparum to this drug. There was a need to test the benefits of ...

    Authors: Alfred B Tiono, Alphonse Ouedraogo, Edith C Bougouma, Amidou Diarra, Amadou T Konaté, Issa Nébié and Sodiomon B Sirima
    Citation: Malaria Journal 2009 8:224
  24. Drug resistant malaria poses an increasing public health problem in Indonesia, especially eastern Indonesia, where malaria is highly endemic. Widespread chloroquine (CQ) resistance and increasing sulphadoxine-...

    Authors: Puji BS Asih, William O Rogers, Agustina I Susanti, Agus Rahmat, Ismail E Rozi, Mariska A Kusumaningtyas, Krisin, Sekartuti, Rita M Dewi, Farah N Coutrier, Awalludin Sutamihardja, Andre JAM van der Ven, Robert W Sauerwein and Din Syafruddin
    Citation: Malaria Journal 2009 8:222
  25. Malaria transmission in Africa occurs predominantly inside houses where the primary vectors prefer to feed. Human preference and investment in blocking of specific entry points for mosquitoes into houses was e...

    Authors: Sheila B Ogoma, Khadija Kannady, Maggy Sikulu, Prosper P Chaki, Nicodem J Govella, Wolfgang R Mukabana and Gerry F Killeen
    Citation: Malaria Journal 2009 8:221
  26. Information on the epidemiology of malaria is essential for designing and interpreting results of clinical trials of drugs, vaccines and other interventions. As a background to the establishment of a site for ...

    Authors: Seth Owusu-Agyei, Kwaku Poku Asante, Martin Adjuik, George Adjei, Elizabeth Awini, Mohammed Adams, Sam Newton, David Dosoo, Dominic Dery, Akua Agyeman-Budu, John Gyapong, Brian Greenwood and Daniel Chandramohan
    Citation: Malaria Journal 2009 8:220
  27. Prompt access to effective treatment for malaria is unacceptably low in Malawi. Less than 20% of children under the age of five with fever receive appropriate anti-malarial treatment within 24 hours of fever o...

    Authors: Alinafe I Chibwana, Don P Mathanga, Jobiba Chinkhumba and Carl H Campbell Jr
    Citation: Malaria Journal 2009 8:219
  28. Insecticide-treated nets (ITNs) are a key intervention to control malaria. The intervention coverage varies as a consequence of geographical accessibility to remote villages and limitations of financial and hu...

    Authors: Yoshihisa Shirayama, Samlane Phompida and Kenji Shibuya
    Citation: Malaria Journal 2009 8:217
  29. Autoregressive regression coefficients for Anopheles arabiensis aquatic habitat models are usually assessed using global error techniques and are reported as error covariance matrices. A global statistic, however...

    Authors: Benjamin G Jacob, Daniel A Griffith, Ephantus J Muturi, Erick X Caamano, John I Githure and Robert J Novak
    Citation: Malaria Journal 2009 8:216
  30. Sequestration of parasitized red blood cells in the microvasculature of major organs involves a sequence of events that is believed to contribute to the pathogenesis of severe falciparum malaria. Plasmodium falci...

    Authors: Happy Phiri, Jacqui Montgomery, Malcolm Molyneux and Alister Craig
    Citation: Malaria Journal 2009 8:214
  31. As malaria control efforts intensify, it is critical to monitor trends in disease burden and measure the impact of interventions. A key surveillance indicator is the incidence of malaria. Yet measurement of in...

    Authors: Trevor P Jensen, Hasifa Bukirwa, Denise Njama-Meya, Damon Francis, Moses R Kamya, Philip J Rosenthal and Grant Dorsey
    Citation: Malaria Journal 2009 8:213
  32. Malaria has recently been identified as a candidate for global eradication. This process will take the form of a series of national eliminations. Key issues must be considered specifically for elimination stra...

    Authors: Lisa J White, Richard J Maude, Wirichada Pongtavornpinyo, Sompob Saralamba, Ricardo Aguas, Thierry Van Effelterre, Nicholas PJ Day and Nicholas J White
    Citation: Malaria Journal 2009 8:212
  33. An assessment of the accuracy of two malaria rapid diagnostic tests (RDT) for the detection of Plasmodium falciparum histidine-rich protein 2 (Pf HRP2) or Pf lactate dehydrogenase (Pf LDH) was undertaken in child...

    Authors: Sandrine Houzé, Mainoumata Dicko Boly, Jacques Le Bras, Philippe Deloron and Jean-François Faucher
    Citation: Malaria Journal 2009 8:211
  34. Past studies in India included only symptomatic pregnant women and thus may have overestimated the proportion of women with malaria. Given the large population at risk, a cross sectional study was conducted in...

    Authors: Davidson H Hamer, Mrigendra P Singh, Blair J Wylie, Kojo Yeboah-Antwi, Jordan Tuchman, Meghna Desai, Venkatachalam Udhayakumar, Priti Gupta, Mohamad I Brooks, Manmohan M Shukla, Kiran Awasthy, Lora Sabin, William B MacLeod, Aditya P Dash and Neeru Singh
    Citation: Malaria Journal 2009 8:210
  35. The global health community is interested in the health impact of the billions of dollars invested to fight malaria in Africa. A recent publication used trends in malaria cases and deaths based on health facil...

    Authors: Alexander K Rowe, S Patrick Kachur, Steven S Yoon, Matthew Lynch, Laurence Slutsker and Richard W Steketee
    Citation: Malaria Journal 2009 8:209
  36. The purpose of this study was to establish whether the "bottle assay", a tool for monitoring insecticide resistance in mosquitoes, can complement and augment the capabilities of the established WHO assay, part...

    Authors: Elvira Zamora Perea, Rosario Balta León, Miriam Palomino Salcedo, William G Brogdon and Gregor J Devine
    Citation: Malaria Journal 2009 8:208
  37. Mefloquine and artesunate combination therapy is the recommended first-line treatment for uncomplicated malaria throughout much of south-east Asia. Concerns have been raised about the potential central nervous...

    Authors: Michael T Ambler, Lilly M Dubowitz, Ratree Arunjerdja, Eh Paw Hla, Kyaw Lay Thwai, Jacher Viladpainguen, Pratap Singhasivanon, Christine Luxemburger, François Nosten and Rose McGready
    Citation: Malaria Journal 2009 8:207
  38. Imported malaria occurs as a relatively rare event in developed countries. As a consequence, most clinicians have little experience in making clinical assessments of disease severity and decisions regarding th...

    Authors: Dennis A Hesselink, Jan-Steven Burgerhart, Hanna Bosmans-Timmerarends, Pieter Petit and Perry JJ van Genderen
    Citation: Malaria Journal 2009 8:206
  39. The spread of drug resistance has been a major obstacle to the control of malaria. The mechanisms underlying drug resistance in malaria seem to be complex and multigenic. The current literature on multiple dru...

    Authors: Reginald A Kavishe, Jeroen MW van den Heuvel, Marga van de Vegte-Bolmer, Adrian JF Luty, Frans GM Russel and Jan B Koenderink
    Citation: Malaria Journal 2009 8:205
  40. Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone...

    Authors: David J Bell, Dan Wootton, Mavuto Mukaka, Jacqui Montgomery, Noel Kayange, Phillips Chimpeni, Dyfrig A Hughes, Malcolm E Molyneux, Steve A Ward, Peter A Winstanley and David G Lalloo
    Citation: Malaria Journal 2009 8:204
  41. Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of ACT, recently adopted by the World...

    Authors: Julien Zwang, Piero Olliaro, Hubert Barennes, Maryline Bonnet, Philippe Brasseur, Hasifa Bukirwa, Sandra Cohuet, Umberto D'Alessandro, Abdulaye Djimdé, Corine Karema, Jean-Paul Guthmann, Sally Hamour, Jean-Louis Ndiaye, Andreas Mårtensson, Claude Rwagacondo, Issaka Sagara…
    Citation: Malaria Journal 2009 8:203
  42. Endemic malaria has been eradicated from France, but some falciparum malaria cases have been described in patients who have never travelled outside the country. Ms. V. 21 year-old and Mr. M. 23 year-old living...

    Authors: Christelle Pomares-Estran, Pascal Delaunay, Annie Mottard, Eric Cua, Pierre-Marie Roger, Bruno Pradines, Daniel Parzy, Hervé Bogreau, Christophe Rogier, Charles Jeannin, Saïd Karch, Didier Fontenille, Dominique Dejour-Salamanca, Fabrice Legros and Pierre Marty
    Citation: Malaria Journal 2009 8:202
  43. In the past decade there has been increasing visibility of malaria control efforts at the national and international levels. The factors that have enhanced this scenario are the availability of proven interven...

    Authors: Ritha JA Njau, Don de Savigny, Lucy Gilson, Eleuther Mwageni and Franklin W Mosha
    Citation: Malaria Journal 2009 8:201

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