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  1. Previous studies have revealed high malaria transmission in Bouaké, Côte d’Ivoire. The sociopolitical crisis in the country and the resulting environmental changes have raised the need to update existing knowl...

    Authors: Florence Fournet, Akre M. Adja, Kouassi A. Adou, Milossé M. C. Dahoui, Baba Coulibaly, Konan F. Assouho, Dounin D. Zoh, Moussa Koné, Aboubacar Koné, Koffi L. Niamien, Sylvie Cornelie, Emmanuel Tia and Nicolas Moiroux
    Citation: Malaria Journal 2022 21:275
  2. Evidence suggests that pre-referral Rectal Artesunate (RAS) can be a life-saving intervention for severe malaria in remote settings in Africa. Recognition of danger signs indicative of severe malaria is critic...

    Authors: Jean Okitawutshu, Aita Signorell, Jean-Claude Kalenga, Eric Mukomena, Giulia Delvento, Christian Burri, Fatou Mwaluke, Valentina Buj, Moulaye Sangare, Sylvie Luketa, Nina Brunner, Tristan Lee, Manuel Hetzel, Christian Lengeler and Antoinette Tshefu
    Citation: Malaria Journal 2022 21:274
  3. Every evening, chimpanzees (Pan troglodytes) build a sleeping platform so called “nest” by intertwining branches of tree. Most of chimpanzees’ communities studied have a preference for tree species in which they ...

    Authors: Camille Lacroux, Emmanuelle Pouydebat, Marie Rossignol, Sophie Durand, Alfred Aleeje, Edward Asalu, Fabrice Chandre and Sabrina Krief
    Citation: Malaria Journal 2022 21:271
  4. Although IPTp-SP is a lifesaving World Health Organization (WHO) recommended preventive intervention for pregnant women in malaria-endemic regions, IPTp-SP uptake in the Northern region of Ghana is much lower ...

    Authors: Abdul Gafaru Mohammed, Dwomoh Duah, Ernest Kenu, Justice Nonvignon, Alex Manu and Harriet Affran Bonful
    Citation: Malaria Journal 2022 21:273
  5. Long-lasting insecticidal nets (LLINs) have been the primary vector control strategy until indoor residual spraying (IRS) was added in Homa Bay and Migori Counties in western Kenya. The objective of this study...

    Authors: Collince J. Omondi, Wilfred O. Otambo, David Odongo, Kevin O. Ochwedo, Antony Otieno, Shirley A. Onyango, Pauline Orondo, Benyl M. Ondeto, Ming-Chieh Lee, Daibin Zhong, James W. Kazura, Andrew K. Githeko and Guiyun Yan
    Citation: Malaria Journal 2022 21:272
  6. Malaria is a major public health concern in The Gambia. There is limited data on the clinical manifestation and outcome of severe malaria in adult patients in The Gambia. The study therefore assessed the clini...

    Authors: Sheikh Omar Bittaye, Abubacarr Jagne, Lamin ES Jaiteh, Behzad Nadjm, Alfred Amambua-Ngwa, Abdul Karim Sesay, Yankuba Singhateh, Emmanuel Effa, Ousman Nyan and Ramou Njie
    Citation: Malaria Journal 2022 21:270
  7. In sub-Saharan Africa, malaria is the common diagnosis for febrile illness and related clinical features, resulting in the under-diagnosis of other aetiologies, such as arboviruses and Rickettsia. While these may...

    Authors: Tatenda Chiuya, Jandouwe Villinger, Laura C. Falzon, Lorren Alumasa, Fredrick Amanya, Armanda D. S. Bastos, Eric M. Fèvre and Daniel K. Masiga
    Citation: Malaria Journal 2022 21:268
  8. Plasmodium falciparum is the most serious, genetically most complex and fastest-evolving malaria parasite. Information on genetic diversity of this parasite would guide policy decision and malaria elimination end...

    Authors: Abeba Gebretsadik Reda, Alebachew Messele, Hussein Mohammed, Ashenafi Assefa, Lemu Golassa and Hassen Mamo
    Citation: Malaria Journal 2022 21:267
  9. Over the last two decades, the scale-up of vector control and changes in the first-line anti-malarial, from chloroquine (CQ) to sulfadoxine-pyrimethamine (SP) and then to artemether-lumefantrine (AL), have res...

    Authors: Zhiyong Zhou, John E. Gimnig, Sheila B. Sergent, Ying Liu, Bernard Abong’o, Kephas Otieno, Winnie Chebore, Monica P. Shah, John Williamson, Feiko O. ter Kuile, Mary J. Hamel, Simon Kariuki, Meghna Desai, Aaron M. Samuels, Edward D. Walker and Ya Ping Shi
    Citation: Malaria Journal 2022 21:265
  10. Sporozoites isolated from the salivary glands of Plasmodium-infected mosquitoes are a prerequisite for several basic and pre-clinical applications. Although salivary glands are pooled to maximize sporozoite recov...

    Authors: Ashutosh K. Pathak, Justine C. Shiau, Blandine Franke-Fayard, Lisa M. Shollenberger, Donald A. Harn, Dennis E. Kyle and Courtney C. Murdock
    Citation: Malaria Journal 2022 21:264
  11. Sri Lanka, an island nation, has eliminated endemic malaria transmission. Maintaining elimination in the continued presence of vectors requires vigilance in screening people travelling from high malaria-risk a...

    Authors: Deepika Fernando, Priyaleela Thota, Saveen Semege, Rahuman Booso, David Bell, Kumudunayana T. de A. W. Gunasekera and Prasad Ranaweera
    Citation: Malaria Journal 2022 21:263
  12. Malaria is extremely common in Ethiopia, and it is one of the country's most serious public health and economic problems. Traditional medicines have long been utilized in Ethiopia by people of various ethnic g...

    Authors: Gashaw Nigussie and Minychel Wale
    Citation: Malaria Journal 2022 21:262
  13. Rapid diagnostic tests (RDT) for malaria are the primary tool for malaria diagnosis in sub-Saharan Africa but the utility of the most commonly used histidine-rich protein 2 (HRP2) antigen-based tests is limite...

    Authors: Emily Lynch, Tomas O. Jensen, Bachir Assao, Menard Chihana, Thadeous Turuho, Dan Nyehangane, John B. Manyok, Harriet Pasquale, Nimol Khim, Benoit Witkowski and Matthew E. Coldiron
    Citation: Malaria Journal 2022 21:261
  14. Glucose-6-phosphate dehydrogenase (G6PD) is cytosolic enzyme, which has a vital role for the integrity and functioning of red blood cells. Lower activity of this enzyme leads to the occurrence of acute haemoly...

    Authors: Tassew Tefera Shenkutie, Desalegn Nega, Asrat Hailu, Daniel Kepple, Logan Witherspoon, Eugenia Lo, Meshesha Tsigie Negash, Aderaw Adamu, Shewayiref Geremew Gebremichael, Bokretsion Gidey, Geremew Tasew, Sindew M. Feleke and Tadesse Kebede
    Citation: Malaria Journal 2022 21:260
  15. Anti-malarial resistance remains an important public health challenge in Cambodia. The effectiveness of three therapies for uncomplicated falciparum malaria was evaluated in Oddar Meanchey province in Northern...

    Authors: Dysoley Lek, Agus Rachmat, Dustin Harrison, Geoffrey Chin, Suwanna Chaoratanakawee, David Saunders, Didier Menard and William O. Rogers
    Citation: Malaria Journal 2022 21:259
  16. Continuous vector surveillance and sustainable interventions are mandatory in order to prevent anopheline proliferation (or spread to new areas) and interrupt malaria transmission. Anopheline abundance and ric...

    Authors: Anne Caroline Alves Meireles, Lucas Rosendo da Silva, Marlon Ferreira Simplício, Alzemar Alves de Lima, Flávia Geovana Fontineles Rios, Carla Augusta de Menezes, Luiz Henrique Maciel Feitoza and Genimar Rebouças Julião
    Citation: Malaria Journal 2022 21:258
  17. Malaria represents one of the most important imported tropical infectious diseases in European travellers. The objective of the study was to identify changes in the epidemiological features of imported malaria...

    Authors: Milan Trojánek, Vyacheslav Grebenyuk, Lenka Richterová, Ivana Zicklerová, Eva Nohýnková, Zdenka Manďáková, Jakub Kantor, Hana Roháčová and František Stejskal
    Citation: Malaria Journal 2022 21:257
  18. Artesunate is recommended by the World Health Organization (WHO) for parenteral treatment of severe Plasmodium falciparum malaria. However, artesunate is inherently unstable in an aqueous solution and hydrolyses ...

    Authors: Fanta Gashe, Evelien Wynendaele, Bart De Spiegeleer and Sultan Suleman
    Citation: Malaria Journal 2022 21:256
  19. Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.

    Authors: Leo Leonardo, Enny Kenangalem, Jeanne R. Poespoprodjo, Rintis Noviyanti, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo and Steven Kho
    Citation: Malaria Journal 2022 21:255
  20. South Africa has set a mandate to eliminate local malaria transmission by 2023. In pursuit of this objective a Sterile Insect Technique programme targeting the main vector Anopheles arabiensis is currently under ...

    Authors: Nonhlanhla L. Ntoyi, Thabo Mashatola, Jérémy Bouyer, Carina Kraupa, Hamidou Maiga, Wadaka Mamai, Nanwintoum S. Bimbile-Somda, Thomas Wallner, Danilo O. Carvalho, Givemore Munhenga and Hanano Yamada
    Citation: Malaria Journal 2022 21:254
  21. The Democratic Republic of the Congo (DRC) organized a first mass distribution campaign of long-lasting insecticidal nets (LLINs) with digitalized data management with coordinated support from the Ministry of ...

    Authors: Joris Losimba Likwela, Phillipe Lukanu Ngwala, Albert Kalonji Ntumba, Deogratias Cibinda Ntale, Eric Mukomena Sompwe, Godé Kanyeba Mpiana, Joseph Kalonji Tshula, Tathy Kalonda Likwela, Patrick Kanku-Ka-Munabe, Adrien N.’siala Kumbi, Gilbert Kulimushi Ndahambara, Helen Cibinda Ntale, Michele Luntadila Kiamenga, Jules Kabongo Njila, Ghislain Makhan Yav, Didier Gasigwa Baneti…
    Citation: Malaria Journal 2022 21:253
  22. Simple and accurate diagnosis is a key component of malaria control programmes. Microscopy is the current gold standard, however it requires extensive training and the results largely rely on the skill of the ...

    Authors: Wataru Kagaya, Ikki Takehara, Kyoko Kurihara, Michael Maina, Chim W. Chan, Gordon Okomo, James Kongere, Jesse Gitaka and Akira Kaneko
    Citation: Malaria Journal 2022 21:252
  23. The ABO blood groups consist of A, B, and H carbohydrate antigens, which regulate protein activities during malaria infection in humans. Understanding the interplay between the malaria parasite and blood group...

    Authors: Redemptah Yeda, Charles Okudo, Eunice Owiti, Gladys Biwot, Cliff Momanyi, Winnie Korir, Thoya Mitsanze, Caroline Tegerei, Dennis Juma, Benjamin Opot, Edwin Mwakio, Gladys Chemwor, Raphael Okoth, Douglas O. Ochora, Agnes C. Cheruiyot, Amanda Roth…
    Citation: Malaria Journal 2022 21:251
  24. Glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PKLR) deficiencies are common causes of erythrocyte haemolysis in the presence of antimalarial drugs such as primaquine and tafenoquine. The presen...

    Authors: Punchalee Mungkalasut, Patcharakorn Kiatamornrak, Watcharapong Jugnam-Ang, Srivicha Krudsood, Poonlarp Cheepsunthorn and Chalisa Louicharoen Cheepsunthorn
    Citation: Malaria Journal 2022 21:250
  25. Plasmodium parasites that cause bird malaria occur in all continents except Antarctica and are primarily transmitted by mosquitoes in the genus Culex. Culex quinquefasciatus, the mosquito vector of avian malaria ...

    Authors: Francisco C. Ferreira, Elin Videvall, Christa M. Seidl, Nicole E. Wagner, A. Marm Kilpatrick, Robert C. Fleischer and Dina M. Fonseca
    Citation: Malaria Journal 2022 21:249
  26. Plasmodium falciparum malaria is recognized as a major global public health problem. The malaria vaccine was important because the case fatality rate of falciparum malaria was high. Plasmodium falciparum circumsp...

    Authors: Zhi-quan He, Qun-qun Zhang, Dan Wang, Ya-bo Hu, Rui-min Zhou, Dan Qian, Cheng-yun Yang, De-ling Lu, Su-hua Li, Ying Liu and Hong-wei Zhang
    Citation: Malaria Journal 2022 21:248
  27. Plasmodium falciparum (Pf) sporozoite (SPZ) vaccines are the only candidate malaria vaccines that induce > 90% vaccine efficacy (VE) against controlled human malaria infection and the only malaria vaccines to ha...

    Authors: Sumana Chakravarty, Melanie J. Shears, Eric R. James, Urvashi Rai, Natasha KC, Solomon Conteh, Lynn E. Lambert, Patrick E. Duffy, Sean C. Murphy and Stephen L. Hoffman
    Citation: Malaria Journal 2022 21:247
  28. Since 2013, the National Malaria Control Programme in mainland Tanzania has deployed annual distributions of insecticide-treated nets (ITNs) through primary schools to maintain ITN access and use. This School ...

    Authors: Hannah Koenker, Matt Worges, Benjamin Kamala, Peter Gitanya, Frank Chacky, Samwel Lazaro, Charles Dismas Mwalimu, Sijenunu Aaron, Deodatus Mwingizi, David Dadi, Ato Selby, Naomi Serbantez, Lulu Msangi, Dana Loll and Joshua Yukich
    Citation: Malaria Journal 2022 21:246
  29. The goal of this study was to understand the epidemiological characteristics of imported malaria in Shanghai specifically during the epidemic period of novel corona-virus pneumonia (COVID-19), to provide a ref...

    Authors: Min Zhu, Chengang Zhang, Yaoguang Zhang, Zhenyu Wang, Xiaojiang Ma, Simin Dai and Jian Chen
    Citation: Malaria Journal 2022 21:245
  30. Parasites are recognized for their ability to modify host physiology and behaviours in ways that increase parasite fitness. Protozoan parasites of the genus Plasmodium are a group of widespread vector-borne paras...

    Authors: Dayvion R. Adams, Andrew J. Golnar, Jacob I. Meyers, Michel A. Slotman and Gabriel L. Hamer
    Citation: Malaria Journal 2022 21:244
  31. The search for pharmacologically effective agents among molecules bearing multiple functionalities is commonly practiced. In continuation of the search for new anti-malarial agents, new pyrazole-hydrazine coup...

    Authors: Akachukwu Ibezim, Martha N. Ofokansi, Xavier Ndukwe, Chidera S. Chiama, Bonaventure C. Obi, Ogechukwu N. Isiogugu, Peter E. Ikechukwu, Akachukwu M. Onwuka, Stella A. Ihim, Jonnie N. Asegbeloyin and Ngozi J. Nwodo
    Citation: Malaria Journal 2022 21:243
  32. Targeted research on residual malaria transmission is important to improve strategies in settings pursuing elimination, where transmission reductions prove challenging. This study aimed to detect and character...

    Authors: Jean Marius Rakotondramanga, Inès Vigan-Womas, Laura C. Steinhardt, Aina Harimanana, Elisabeth Ravaoarisoa, Tsikiniaina L. Rasoloharimanana, Seheno Razanatsiorimalala, Amy Wesolowski, Milijaona Randrianarivelojosia, Benjamin Roche and Andres Garchitorena
    Citation: Malaria Journal 2022 21:242
  33. As Indonesia aims for malaria elimination by 2030, provisional malaria epidemiology and risk factors evaluation are important in pursue of this national goal. Therefore, this study aimed to understand the risk...

    Authors: Fahmi Fahmi, Ayodhia Pitaloka Pasaribu, Minerva Theodora and Kinley Wangdi
    Citation: Malaria Journal 2022 21:241

    The Correction to this article has been published in Malaria Journal 2022 21:335

  34. Malaria infection during pregnancy can cause significant morbidity and mortality to a pregnant woman, her fetus and newborn. In areas of high endemic transmission, gravidity is an important risk factor for inf...

    Authors: Ayodele Akinnawo, Kaali Seyram, Ellen Boamah Kaali, Samuel Harrison, David Dosoo, Matthew Cairns and Kwaku Poku Asante
    Citation: Malaria Journal 2022 21:240
  35. Globally, nearly half of all deaths among children under the age of 5 years can be attributed to malaria, diarrhoea, and pneumonia. A significant proportion of these deaths occur in sub-Saharan Africa. Despite...

    Authors: Neha Batura, Frida Kasteng, Juliao Condoane, Benson Bagorogosa, Ana Cristina Castel-Branco, Edmound Kertho, Karin Källander, Seyi Soremekun, Raghu Lingam and Anna Vassall
    Citation: Malaria Journal 2022 21:239
  36. Pyrethroid resistance observed in populations of malaria vectors is widespread in Ethiopia and could potentially compromise the effectiveness of insecticide-based malaria vector control interventions. In this ...

    Authors: Delenasaw Yewhalaw, Meshesha Balkew, Endalew Zemene, Sheleme Chibsa, Peter Mumba, Cecilia Flatley, Aklilu Seyoum, Melissa Yoshimizu, Sarah Zohdy, Dereje Dengela and Seth Irish
    Citation: Malaria Journal 2022 21:238
  37. The vector species in the Amazon River Basin are regionally and locally diverse, which makes it imperative to understand and compare their roles in malaria transmission to help select appropriate methods of in...

    Authors: Robert H. Zimmerman, Allan K. R. Galardo, L Philip Lounibos, Clicia Galardo, A. Kadir Bahar and Edzard van Santen
    Citation: Malaria Journal 2022 21:237
  38. Malaria rapid diagnostic tests (RDTs) have expanded diagnostic service to remote endemic communities in Ethiopia, where 70% of malaria services per annum are reliant on them. However, diagnostic strategies are...

    Authors: Sindew Mekasha Feleke, Bokretsion Gidey, Hussein Mohammed, Desalegn Nega, Dereje Dillu, Mebrhatom Haile, Hiwot Solomon, Jonathan B. Parr, Getachew Tollera, Geremew Tasew, Hassen Mamo and Beyene Petros
    Citation: Malaria Journal 2022 21:236
  39. Evolutionary pressures lead to the selection of efficient malaria vectors either resistant or susceptible to Plasmodium parasites. These forces may favour the introduction of species genotypes that adapt to new b...

    Authors: Shirley A. Onyango, Kevin O. Ochwedo, Maxwell G. Machani, Julius O. Olumeh, Isaiah Debrah, Collince J. Omondi, Sidney O. Ogolla, Ming-Chieh Lee, Guofa Zhou, Elizabeth Kokwaro, James W. Kazura, Yaw A. Afrane, Andrew K. Githeko, Daibin Zhong and Guiyun Yan
    Citation: Malaria Journal 2022 21:235
  40. To contribute to the mission of the National Malaria Control Programme (NMCP) and guide future interventions in Cameroon in general, and in Makenene in particular, this study assessed the knowledge, attitudes ...

    Authors: Joel Djoufounna, Roland Bamou, Marie Paul Audrey Mayi, Nelly Armanda Kala-Chouakeu, Raymond Tabue, Parfait Awono-Ambene, Dorothy Achu-Fosah, Christophe Antonio-Nkondjio and Timoléon Tchuinkam
    Citation: Malaria Journal 2022 21:234
  41. Rapid diagnostic tests (RDTs) that rely on the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) have become key tools for diagnosing P. falciparum infection. The utility of RDTs can be limited...

    Authors: Louise Marquart, Lachlan Webb, Peter O’Rourke, Michelle L. Gatton, Michelle S. Hsiang, Michael Kalnoky, Ihn Kyung Jang, Henry Ntuku, Davis R. Mumbengegwi, Gonzalo J. Domingo, James S. McCarthy and Sumudu Britton
    Citation: Malaria Journal 2022 21:233
  42. Data integration and visualisation techniques have been widely used in scientific research to allow the exploitation of large volumes of data and support highly complex or long-lasting research questions. Inte...

    Authors: Alberto Pietro Sironi, Juracy Bertoldo, Vanderson Sampaio, Danilo Coimbra, Davide Rasella and Marcos Ennes Barreto
    Citation: Malaria Journal 2022 21:232
  43. The increase in detections of Plasmodium vivax infection in Duffy-negative individuals in Africa has challenged the dogma establishing the unique P. vivax Duffy Binding Protein-Duffy antigen receptor for chemokin...

    Authors: Andargie Abate, Isabelle Bouyssou, Solenne Mabilotte, Cecile Doderer-Lang, Laurent Dembele, Didier Menard and Lemu Golassa
    Citation: Malaria Journal 2022 21:230
  44. The automated haematology analyzer XN-31 prototype (XN-31p) is a new flow cytometry-based device developed to measure the number and the ratio of malaria-infected red blood cells (MI-RBC) with a complete blood...

    Authors: Kanako Komaki-Yasuda, Satoshi Kutsuna, Miki Kawaguchi, Mina Kamei, Kinya Uchihashi, Keiji Nakamura, Takato Nakamoto, Norio Ohmagari and Shigeyuki Kano
    Citation: Malaria Journal 2022 21:229
  45. The use of long-lasting insecticide-treated nets (LLINs) is one of the main malaria prevention method promoted by the World Health Organization (WHO) in Côte d'Ivoire. LLIN-coverage has reached 95% since 2015 ...

    Authors: Gnagoran Kouakou Daniel N’Guessan, Fangala Hamidou Coulibaly, Antoine Marc Gaby Barreaux, Roseline Josée Yapo, Kouassi Arsène Adou, Emmanuel Tia and Florence Fournet
    Citation: Malaria Journal 2022 21:228
  46. Rapid diagnostic tests (RDT) are widely used for malaria diagnosis in Madagascar, where Plasmodium falciparum is the predominant species. Molecular diagnosis is essential for malaria surveillance, but requires ad...

    Authors: Voahangy Hanitriniaina I. Andrianaranjaka, Elisabeth Ravaoarisoa, Tovonahary A. Rakotomanga, Fanomezantsoa Ralinoro, Danielle A. Doll Rakoto, Ranjàna H. Randrianarivo, Victor Jeannoda and Arsène Ratsimbasoa
    Citation: Malaria Journal 2022 21:227
  47. Gene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a promising new vector control strategy to reinvigorate the fight agains...

    Authors: Shirley Leung, Nikolai Windbichler, Edward A Wenger, Caitlin A Bever and Prashanth Selvaraj
    Citation: Malaria Journal 2022 21:226

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