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  1. The current first-line treatments for uncomplicated malaria recommended by the National Malaria Control Programme in Mali are artemether–lumefantrine (AL) and artesunate–amodiaquine (ASAQ). From 2015 to 2016, ...

    Authors: Youssouf Diarra, Oumar Koné, Lansana Sangaré, Lassina Doumbia, Dade Bouye Ben Haidara, Mouctar Diallo, Ababacar Maiga, Hamadoun A. Sango, Halidou Sidibé, Jules Mihigo, Douglas Nace, Dragan Ljolje, Eldin Talundzic, Venkatachalam Udhayakumar, Erin Eckert, Celia J. Woodfill…

    Citation: Malaria Journal 2021 20:235

    Content type: Research

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  2. The coronavirus disease 2019 (COVID-19) pandemic has posed a unique challenge to health care systems globally. To curb COVID-19 transmission, mitigation measures such as travel restrictions, border closures, c...

    Authors: Samuel Gavi, Oscar Tapera, Joseph Mberikunashe and Mufaro Kanyangarara

    Citation: Malaria Journal 2021 20:233

    Content type: Case study

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  3. Current standard interventions are not universally sufficient for malaria elimination. The effects of community-based house improvement (HI) and larval source management (LSM) as supplementary interventions to...

    Authors: Robert S. McCann, Alinune N. Kabaghe, Paula Moraga, Steven Gowelo, Monicah M. Mburu, Tinashe Tizifa, Michael G. Chipeta, William Nkhono, Aurelio Di Pasquale, Nicolas Maire, Lucinda Manda-Taylor, Themba Mzilahowa, Henk van den Berg, Peter J. Diggle, Dianne J. Terlouw, Willem Takken…

    Citation: Malaria Journal 2021 20:232

    Content type: Research

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  4. In malaria endemic regions, intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for all pregnant women during prenatal consultation, from the fourth month of pregnancy up ...

    Authors: Oumar Sangho, Moctar Tounkara, Lillian Joyce Whiting-Collins, Madeleine Beebe, Peter J. Winch and Seydou Doumbia

    Citation: Malaria Journal 2021 20:231

    Content type: Research

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  5. Mosquito species from the Anopheles gambiae complex and the Anopheles funestus group are dominant African malaria vectors. Mosquito microbiota play vital roles in physiology and vector competence. Recent research...

    Authors: Bianca E Silva, Zvifadzo Matsena Zingoni, Lizette L. Koekemoer and Yael L. Dahan-Moss

    Citation: Malaria Journal 2021 20:230

    Content type: Research

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  6. Malaria is a major public health problem in India and accounts for about 88% of malaria burden in South-East Asia. India alone accounted for 2% of total malaria cases globally. Anti-malarial drug resistance is...

    Authors: Sri Krishna, Sweta Mishra, Prakash Tiwari, Anup K. Vishwakarma, Sushrikanta Khandai, Suyesh Shrivastava, Anil K. Verma, Shashikant Tiwari, Hari Barman, Surendra Jhariya, Pradeep Tiwari, Anup S. Tidgam, Brij M. Varun, Sunil Singh, Naresh Yerane, Chintaman R. Tembhurne…

    Citation: Malaria Journal 2021 20:229

    Content type: Research

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  7. The over-distributed pattern of malaria transmission has led to attempts to define malaria “hotspots” that could be targeted for purposes of malaria control in Africa. However, few studies have investigated th...

    Authors: Alice Kamau, Grace Mtanje, Christine Mataza, Philip Bejon and Robert W. Snow

    Citation: Malaria Journal 2021 20:227

    Content type: Research

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  8. Malaria vector control relies upon the use of insecticide-treated nets and indoor residual spraying. However, as the emergency of insecticide resistance in malaria vectors grows, the effectiveness of these mea...

    Authors: Alphonse Traoré, Gérard Niyondiko, Antoine Sanou, Franck Langevin, N’Falé Sagnon, Adama Gansané and Moussa Wamdaogo Guelbeogo

    Citation: Malaria Journal 2021 20:226

    Content type: Research

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  9. Loop-mediated isothermal amplification (LAMP) for malaria diagnosis at the point of care (POC) depends on the detection capacity of synthesized nucleic acids and the specificity of the amplification target. To...

    Authors: Oscar Nolasco, Jhoel Montoya, Ana L. Rosales Rosas, Scarlett Barrientos, Anna Rosanas-Urgell and Dionicia Gamboa

    Citation: Malaria Journal 2021 20:225

    Content type: Research

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  10. Sixty percent of the Ethiopia population is at risk of malaria, with the highest prevalence reported in Gambella (6%) and Benishangul-Gumuz (3%) regions. Within these regions are large agricultural development...

    Authors: Yehualashet Tadesse, Seth R. Irish, Sheleme Chibsa, Sisay Dugassa, Lena M. Lorenz, Asfawesen Gebreyohannes, Hiwot Teka, Hiwot Solomon, Eshetu Gezahegn, Yonas Petros, Mesfin Haile, Mesfin Eshetu and Matthew Murphy

    Citation: Malaria Journal 2021 20:224

    Content type: Research

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  11. To improve the coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) in Africa, Medicines for Malaria Venture (MMV) developed, tested and validated a new packaging of sulfadoxine–pyrimet...

    Authors: Sylvain Landry Birane Faye and Maud Majeres Lugand

    Citation: Malaria Journal 2021 20:223

    Content type: Research

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  12. For uncomplicated Plasmodium falciparum malaria, highly efficacious single-dose treatments are expected to increase compliance and improve treatment outcomes, and thereby may slow the development of resistance. T...

    Authors: Yeka Adoke, Rella Zoleko-Manego, Serge Ouoba, Alfred B. Tiono, Grace Kaguthi, Juvêncio Eduardo Bonzela, Tran Thanh Duong, Alain Nahum, Marielle Bouyou-Akotet, Bernhards Ogutu, Alphonse Ouedraogo, Fiona Macintyre, Andreas Jessel, Bart Laurijssens, Mohammed H. Cherkaoui-Rbati, Cathy Cantalloube…

    Citation: Malaria Journal 2021 20:222

    Content type: Research

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  13. Efforts to study the biology of Plasmodium vivax liver stages, particularly the latent hypnozoites, have been hampered by the limited availability of P. vivax sporozoites. Anopheles stephensi is a major urban mal...

    Authors: Ajeet Kumar Mohanty, Charles de Souza, Deepika Harjai, Prathamesh Ghavanalkar, Mezia Fernandes, Anvily Almeida, Jayashri Walke, Suresh Kumar Manoharan, Ligia Pereira, Rashmi Dash, Anjali Mascarenhas, Edwin Gomes, Thanyapit Thita, Laura Chery, Anupkumar R. Anvikar, Ashwani Kumar…

    Citation: Malaria Journal 2021 20:221

    Content type: Research

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  14. Sleeping under an ITN reduces contact with mosquitoes through the combination of a physical barrier and an insecticidal effect, which reduces the incidence of malaria. The 2016–2020 Burkina Faso National Malar...

    Authors: Mahamadi Tassembedo, Soumaila Coulibaly and Boukary Ouedraogo

    Citation: Malaria Journal 2021 20:220

    Content type: Research

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  15. Insecticide-treated bed nets (ITNs) are widely used for the prevention and control of malaria. In Guatemala, since 2006, ITNs have been distributed free of charge in the highest risk malaria-endemic areas and ...

    Authors: María Eugenia Castellanos, Soledad Rodas, José Guillermo Juárez, Juan Carlos Lol, Sayra Chanquin, Zoraida Morales, Lucrecia Vizcaino, Stephen C. Smith, Jodi Vanden Eng, Henok G. Woldu, Audrey Lenhart and Norma Padilla

    Citation: Malaria Journal 2021 20:219

    Content type: Research

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  16. Malaria control and elimination strategies are based on levels of transmission that are usually determined by data collected from health facilities. In endemic areas, asymptomatic Plasmodium infection is thought ...

    Authors: Aida Sadikh Badiane, Tolla Ndiaye, Alphonse Birane Thiaw, Deme Awa Binta, Mamadou Alpha Diallo, Mame Cheikh Seck, Khadim Diongue, Mamane Nassirou Garba, Mouhamadou Ndiaye and Daouda Ndiaye

    Citation: Malaria Journal 2021 20:218

    Content type: Research

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  17. The radical cure of Plasmodium vivax requires treatment with an 8-aminoquinoline drug, such as primaquine and tafenoquine, to eradicate liver hypnozoite stages, which can reactivate to cause relapsing infections....

    Authors: Nora Engel, Cristian Ghergu, Mohammad Abdul Matin, Mohammad Golam Kibria, Kamala Thriemer, Ric N. Price, Xavier C. Ding, Rosalind E. Howes, Benedikt Ley, Sandra Incardona and Mohammad Shafiul Alam

    Citation: Malaria Journal 2021 20:217

    Content type: Research

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  18. In French Guiana, gold miners working illegally represents a major reservoir of malaria. This mobile population, mainly of Brazilian descent, enters the French Guianese forest from neighbouring countries, Suri...

    Authors: Muriel Suzanne Galindo, Yann Lambert, Louise Mutricy, Laure Garancher, Jane Bordalo Miller, José Hermenegildo Gomes, Alice Sanna, Cassio Peterka, Hélène Hilderal, Hedley Cairo, Helene Hiwat, Mathieu Nacher, Martha Cecilia Suárez-Mutis, Stephen Vreden and Maylis Douine

    Citation: Malaria Journal 2021 20:216

    Content type: Methodology

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  19. European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac issues, of art...

    Authors: Nicolas Vignier, Olivier Bouchaud, Andrea Angheben, Emmanuel Bottieau, Guido Calleri, Joaquín Salas-Coronas, Charlotte Martin, José Manuel Ramos, Matthieu Mechain, Christophe Rapp, Hans-Dieter Nothdurft, Maria Velasco, Azucena Bardají, Gerardo Rojo-Marcos, Leo G. Visser, Christoph Hatz…

    Citation: Malaria Journal 2021 20:214

    Content type: Research

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  20. Regular monitoring of anti-malarial drug efficacy is vital for establishing rational malaria treatment guidelines and ensuring adequate treatment outcomes. This study aimed to synthesize the available evidence...

    Authors: Abdulhakim Abamecha, Daniel Yilma, Wondimagegn Adissu, Delenasaw Yewhalaw and Alemseged Abdissa

    Citation: Malaria Journal 2021 20:213

    Content type: Research

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  21. Understanding of the impacts of climatic variability on human health remains poor despite a possibly increasing burden of vector-borne diseases under global warming. Numerous socioeconomic variables make such ...

    Authors: Tzu Tung Chen, Fredrik Charpentier Ljungqvist, Helene Castenbrandt, Franziska Hildebrandt, Mathias Mølbak Ingholt, Jenny C. Hesson, Johan Ankarklev, Kristina Seftigen and Hans W. Linderholm

    Citation: Malaria Journal 2021 20:212

    Content type: Case study

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  22. Malaria in endemic countries is often asymptomatic during pregnancy, but it has substantial consequences for both the mother and her unborn baby. During pregnancy, anaemia is an important consequence of malari...

    Authors: Toussaint Rouamba, Sékou Samadoulougou, Mady Ouédraogo, Hervé Hien, Halidou Tinto and Fati Kirakoya-Samadoulougou

    Citation: Malaria Journal 2021 20:211

    Content type: Research

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  23. Imported malaria parasites with anti-malarial drug resistance (ADR) from Africa is a serious public health challenge in non-malarial regions, including Wuhan, China. It is crucial to assess the ADR status in A...

    Authors: Weijia Cheng, Xiaonan Song, Huabing Tan, Kai Wu and Jian Li

    Citation: Malaria Journal 2021 20:209

    Content type: Research

    Published on:

  24. In malaria elimination settings, available metrics for malaria surveillance have been insufficient to measure the performance of passive case detection adequately. An indicator for malaria suspected cases with...

    Authors: Diego Rios-Zertuche, Keith H. Carter, Katie Panhorst Harris, Max Thom, Maria Paola Zúñiga-Brenes, Pedro Bernal-Lara, Álvaro González-Marmol, Casey K. Johanns, Bernardo Hernández, Erin Palmisano, Rebecca Cogen, Paulami Naik, Charbel El Bcheraoui, David L. Smith, Ali H. Mokdad and Emma Iriarte

    Citation: Malaria Journal 2021 20:208

    Content type: Research

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  25. The Plasmodium falciparum antigen histidine rich protein 2 (HRP2) is a preferred target for malaria rapid diagnostic tests (RDTs) because of its abundant production by the parasite and thermal stability. As a res...

    Authors: Amy Kong, Scott A. Wilson, Yong Ah, Douglas Nace, Eric Rogier and Michael Aidoo

    Citation: Malaria Journal 2021 20:207

    Content type: Research

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  26. Post-artesunate delayed haemolysis (PADH) is common after severe malaria episodes. PADH is related to the “pitting” phenomenon and the synchronous delayed clearance of once-infected erythrocytes, initially spa...

    Authors: Tommaso Ascoli Bartoli, Luciana Lepore, Alessandra D’Abramo, Giovanna Adamo, Angela Corpolongo, Laura Scorzolini, Maria Letizia Giancola, Nazario Bevilacqua, Claudia Palazzolo, Andrea Mariano, Giuseppe Ippolito, Pierre Buffet and Emanuele Nicastri

    Citation: Malaria Journal 2021 20:206

    Content type: Research

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  27. Drug-resistant falciparum malaria is an increasing public health burden. This study examined the magnitude of Plasmodium falciparum infection and the patterns and predictors of treatment failure in Vietnam.

    Authors: Minh Cuong Duong, Oanh Kieu Nguyet Pham, Phong Thanh Nguyen, Van Vinh Chau Nguyen and Phu Hoan Nguyen

    Citation: Malaria Journal 2021 20:205

    Content type: Research

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  28. An assessment of the Sterile Insect Technique (SIT) as a complementary malaria vector control tool, is at an advanced stage in South Africa. The technique involves the release of laboratory-reared sterilized m...

    Authors: Pinky N. Manana, Sara Jewett, Jabulani Zikhali, Dumsani Dlamini, Nondumiso Mabaso, Zothile Mlambo, Roxanne Ngobese and Givemore Munhenga

    Citation: Malaria Journal 2021 20:204

    Content type: Research

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  29. To further reduce malaria burden, identification of areas with highest burden for targeted interventions needs to occur. Routine health information has the potential to indicate where and when clinical malaria...

    Authors: Tinashe A. Tizifa, William Nkhono, Spencer Mtengula, Michele van Vugt, Zachary Munn and Alinune N. Kabaghe

    Citation: Malaria Journal 2021 20:203

    Content type: Research

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  30. Malaysia is on track towards malaria elimination. However, several cases of malaria still occur in the country. Contributing factors and communal aspects have noteworthy effects on any malaria elimination acti...

    Authors: Mohd Bakhtiar Munajat, Mohd Amirul Fitri A. Rahim, Wathiqah Wahid, Mohd Ikhwan Mukmin Seri Rakna, Paul C. S. Divis, Sriwipa Chuangchaiya, Inke Nadia D. Lubis, Emelia Osman, Muhd Rafiq Mohd Kasri and Zulkarnain Md Idris

    Citation: Malaria Journal 2021 20:202

    Content type: Research

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  31. Thailand’s National Malaria Elimination Strategy 2017–2026 introduced the 1-3-7 strategy as a robust surveillance and response approach for elimination that would prioritize timely, evidence-based action. Unde...

    Authors: Cheewanan Lertpiriyasuwat, Prayuth Sudathip, Suravadee Kitchakarn, Darin Areechokchai, Sathapana Naowarat, Jui A. Shah, David Sintasath, Niparueradee Pinyajeerapat, Felicity Young, Krongthong Thimasarn, Deyer Gopinath and Preecha Prempree

    Citation: Malaria Journal 2021 20:201

    Content type: Case study

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  32. Insecticide-treated net (ITN) use is crucial for preventing malaria infection. Despite significant improvements in ITN access and use over the past two decades, many malaria-endemic countries in sub-Saharan Af...

    Authors: Julia Scott, Mufaro Kanyangarara, Abel Nhama, Eusebio Macete, William John Moss and Francisco Saute

    Citation: Malaria Journal 2021 20:200

    Content type: Research

    Published on:

  33. The aim of this study was to investigate and analyse the characteristics of malaria in Shanghai from 2010 to 2019 and to provide suggestions for areas with a similar elimination process in China in order to pr...

    Authors: Simin Dai, Min Zhu, Huanyu Wu, Yaoguang Zhang, Zhenyu Wang, Chengang Zhang, Xiaojiang Ma and Li Jiang

    Citation: Malaria Journal 2021 20:199

    Content type: Research

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  34. The World Health Organization (WHO) recommends consideration of mass drug administration (MDA) for malaria control in low-endemic settings approaching elimination. However, MDA remains a controversial strategy...

    Authors: Alexandra Fehr, Claudia Nieto-Sanchez, Joan Muela, Fatou Jaiteh, Omar Ceesay, Ebrima Maneh, Dullo Baldeh, Jane Achan, Edgard Dabira, Bakary Conteh, Joske Bunders-Aelen, Tom Smekens, Henk Broekhuizen, Umberto D’Alessandro and Koen Peeters Grietens

    Citation: Malaria Journal 2021 20:198

    Content type: Research

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  35. The lack of background disease incidence rates in sub-Saharan countries where the RTS,S/AS01E malaria vaccine is being implemented may hamper the assessment of vaccine safety and effectiveness. This study aimed t...

    Authors:

    Citation: Malaria Journal 2021 20:197

    Content type: Research

    Published on:

    The Correction to this article has been published in Malaria Journal 2021 20:252

  36. Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-T...

    Authors: Gabriela Samayoa-Reyes, Conner Jackson, Sidney Ogolla, Katherine Sabourin, Adeola Obajemu, Arlene E. Dent, Ludmilla Prokunina-Olsson and Rosemary Rochford

    Citation: Malaria Journal 2021 20:196

    Content type: Research

    Published on:

  37. Multi-pronged malaria elimination strategies are increasingly being considered for accelerating efforts against malaria transmission in Southeast Asia. Two malaria prevention interventions used in in the regio...

    Authors: Breagh Cheng, Saw Nay Htoo, Naw Pue Pue Mhote and Colleen M. Davison

    Citation: Malaria Journal 2021 20:195

    Content type: Research

    Published on:

  38. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy in humans, is prevalent in tropical and subtropical areas where malaria is endemic. Anti-malarial drugs, such as primaquine and ...

    Authors: Usa Boonyuen, Duantida Songdej, Sasipa Tanyaratsrisakul, Suparat Phuanukoonnon, Kamonwan Chamchoy, Aun Praoparotai, Phonchanan Pakparnich, Sirapapha Sudsumrit, Thomas Edwards, Christopher T. Williams, Rachel L. Byrne, Emily R. Adams and Mallika Imwong

    Citation: Malaria Journal 2021 20:194

    Content type: Research

    Published on:

  39. High altitude settings in Eastern Africa have been reported to experience increased malaria burden due to vector habitat expansion. This study explored possible associations between malaria test positivity rat...

    Authors: Nancy A. Kassam, Robert D. Kaaya, Damian J. Damian, Christentze Schmiegelow, Reginald A. Kavishe, Michael Alifrangis and Christian W. Wang

    Citation: Malaria Journal 2021 20:193

    Content type: Research

    Published on:

  40. Private sector malaria programmes contribute to government-led malaria elimination strategies in Cambodia, Lao PDR, and Myanmar by increasing access to quality malaria services and surveillance data. However, ...

    Authors: Ann Levin, Rebecca Potter, Kemi Tesfazghi, Saysana Phanalangsy, Phally Keo, Elijah Filip, Si Hein Phone and M. James Eliades

    Citation: Malaria Journal 2021 20:192

    Content type: Research

    Published on:

  41. Mosquito feeding assays using venous blood are commonly used for evaluating the transmission potential of malaria infected individuals. To improve the accuracy of these assays, care must be taken to prevent pr...

    Authors: Harouna M. Soumare, Wamdaogo Moussa Guelbeogo, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Zongo Soumanaba, Alphonse Ouedraogo, Maurice S. Ouattara, Ahmad Abdullahi, Lamin Jadama, Muhammed M. Camara, Pa Modou Gaye, Michael Mendy, Nwakanma Davis, Alfred B. Tiono, Umberto D’Alessandro, Chris Drakeley…

    Citation: Malaria Journal 2021 20:191

    Content type: Research

    Published on:

  42. Two recent initiatives, the World Health Organization (WHO) Strategic Advisory Group on Malaria Eradication and the Lancet Commission on Malaria Eradication, have assessed the feasibility of achieving global m...

    Authors: Hannah Nissan, Israel Ukawuba and Madeleine Thomson

    Citation: Malaria Journal 2021 20:190

    Content type: Review

    Published on:

    The Correction to this article has been published in Malaria Journal 2021 20:215

  43. Many public health interventions lead to disruption or decrease of transmission, providing a beneficial effect for people in the population regardless of whether or not they individually participate in the int...

    Authors: Sai Thein Than Tun, Daniel M. Parker, Ricardo Aguas and Lisa J. White

    Citation: Malaria Journal 2021 20:189

    Content type: Research

    Published on:

  44. Malaria remains a global health concern and is endemic in Limpopo, Mpumalanga and KwaZulu Natal Provinces of South Africa, which aims to eliminate malaria by 2025. Community engagement plays a significant role...

    Authors: Mukhethwa Munzhedzi, Elizabeth T. Rogawski McQuade, Jennifer L. Guler, Piper E. Shifflett, Sara Krivacsy, Rebecca Dillingham and Pascal O. Bessong

    Citation: Malaria Journal 2021 20:188

    Content type: Research

    Published on:

  45. Uganda's clinical management guidelines recommend a malaria laboratory test in all patients presenting with fever (history of fever or an axillary temperature ≥ 37.5 °C), and only those with a positive test re...

    Authors: Angella Atukunda, Mwaka Amos Deogratius, Emmanuel Arinaitwe, Philip Orishaba, Moses R. Kamya and Joaniter I. Nankabirwa

    Citation: Malaria Journal 2021 20:187

    Content type: Research

    Published on:

  46. Pregnant women are particularly vulnerable to malaria infections, increasing the risk of maternal–fetal complications, mainly in high-endemicity areas. However, few studies of malaria in pregnancy (MiP) have b...

    Authors: Mariestéfany Romero, Elízabeth Leiba, Fhabián S. Carrión-Nessi, Diana C. Freitas-De Nobrega, Serris Kaid-Bay, Ángel F. Gamardo, Melynar Chavero, Luisamy Figuera, Natasha A. Camejo-Ávila, María V. Marcano, Mary Lopez-Perez and David A. Forero-Peña

    Citation: Malaria Journal 2021 20:186

    Content type: Research

    Published on:

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