Hypokalaemic paralysis in an adult case of Plasmodium vivax malaria

Hypokalaemia and its subsequent complications are more often seen in children rather than in adults and are more common with falciparum malaria. This is a case of a 26-year-old male with Plasmodium vivax malaria who had developed paraparesis secondary to hypokalaemia. His treatment involved correction of the potassium level as well as the treatment of malaria. Such an atypical manifestation of malaria in an adult has not been previously documented.

limbs with no sensory deficit. The cranial nerves examination was normal. The patient was admitted to the hospital and his blood samples were sent for urgent tests for serum electrolytes. The results revealed a potassium value of 1.47 mEq/L. The ECG, correspondingly, showed flattened T waves and the presence of U waves.
Intravenous potassium chloride was given for correcting the potassium level and, since it was a life-threatening hypokalaemia (<1.5 mEq/L), at a relatively rapid rate of 30 mEqs/hr. Repeat serum chemistry after three hours showed a potassium value of 2.67 mEq/L. There was some improvement in clinical signs of weakness and ECG. The rate of correction was subsequently slowed down to 20mEqs/ hr. After a total infusion of 150 mEqs potassium IV, electrolyte tests repeated after 8 hours, showed a potassium value of 5.25 mEq/L. Potassium supplementation was then stopped. The correlation of the potassium value with the neurological examination and ECG is given in Table 1, also indicating the moments when potassium supplementation was carried out. The patient did not have any complaints after 8 hours of hospitalization. The repeat electrolytes tests done on the subsequent days revealed potassium in the normal range. The correlation of the potassium value with the lower limb neurological examination findings over the course of hospitalization is given in Figure 1.
Arterial blood gas, serum magnesium, serum calcium, blood sugar and renal function were within normal limits. The liver function tests showed mild indirect bilirubinemia. His urine test results were within the normal range. The patient also tested negative for dengue, leptospirosis and HIV. Total T4 was mildly elevated; however, TSH and Total T3 were normal. The summary of the blood investigations is given in Table 2.
The patient received artesunate 120mg IV 12 hourly on day 1 followed by od dose for two days, ceftriaxone 1gm IV 12 hourly for three days and doxycycline 100mg po bid for five days. Injectibles were stopped on day 4 and he was put on artemether/lumefantrine 80/480mg po bid for three days; and to prevent a relapse, primaquine 7.5mg po bid was added for fourteen days after testing for glucose-6-phosphate dehydrogenase deficiency.
The patient was discharged home on day 5. He returned for a follow-up consultation two weeks later. He did not have any complaints, including fever, during that intervening period.

Discussion
Around 1.5 million confirmed cases of malaria are reported from India annually. The current national policy recommends artemisinin combination therapy for falciparum cases and chloroquine plus primaquine for vivax cases. Oral artemisinin monotherapy is banned in India to prevent resistance. However, the policy also recommends prompt treatment of severe malaria with parenteral artemisinin derivatives or quinine [1]. In the region of greater Mumbai, malaria has a high prevalence of more than 1 case per 1,000 population [2]. Resistance to chloroquine has been steadily rising in this region as well [3]. As a result, across the region, for treatment of even vivax cases, artemisinin combination therapy has become quite popular, with an addition of doxycycline or clindamycin.
Dworak et al. stated that there was a progressive decrease in the sodium and potassium levels within 12 hrs of the parasite's entry into the host [4]. Hypokalaemia in malaria has been observed in falciparum cases in children, where the underlying cause was proposed to be the correction of acidosis seen usually in severe cases of malaria [5]. A study from Gujarat, India, found hyponatremia and hypokalaemia to be more common in falciparum than vivax malaria [6]. Another study from Nigeria showed significantly lowered Table 1 The correlation of the potassium value with the neurological examination and ECG   Note: Other investigations like liver enzymes, serum uric acid, serum proteins, serum albumin, blood sugars and urine (routine and microscopy) were within normal limits.
sodium and potassium levels in malaria infection [7]. In their analysis, Thanachartwet et al. found a high prevalence of hypokalaemia in Thai patients with malaria, and significant association of hypokalaemia with vivax infection, hyponatraemia and hypovolaemia. They postulated that the hypokalaemia was multifactorial, from a combination of intracellular translocation of potassium from extracellular fluid and urinary potassium loss [8].
Case reports have been published concerning motor weakness secondary to hypokalaemia in other infectious diseases in adults, namely chikungunya [9], dengue fever [10] and leptospirosis [11]. Periodic paralysis has also been reported in malaria wherein the combination of transient hyperkalaemia and rigors occurring during febrile episodes of malaria has been suggested as the underlying cause which precipitating muscular paralysis [12]. Although malaria has been found to be associated with various neurological and psychiatric complications, and neurological manifestations to anti-malarial drugs have been documented [13]; the authors could not find any literature documenting the association of such a type of motor weakness (hypokalaemic) with malaria.
There have been case reports of malaria causing Guillian Barre Syndrome [14,15], but since the patient's recovery from the paraparesis was dramatic and complete within a few hours of potassium supplementation, it was easily excluded from the differential diagnosis and neither the EMG/NCV studies nor a lumbar puncture (for CSF analysis) was performed. Since the patient had only lower limb muscle weakness, without the involvement of any higher functions or cranial nerves and in the absence of upper motor neuron signs, MRI was not performed.
There was no obvious fluid loss since there was no report of vomiting or diarrhoea or any altered urine output. Increased catecholamine levels in response to stress of the infection and secondary insulin release may result in intracellular shift of potassium and hypokalaemia. Hyperventilation due to hyperpyrexia and respiratory alkalosis has also been suggested as a cause for hypokalaemia [16].
The patient's magnesium levels were normal and T4 was mildly elevated. There was no strenuous exercise preceding the weakness thereby ruling out any glycogen storage disorder. Also, since there was no similar episode of weakness in the past or any family history of it, familial channelopathies were not included in the differential diagnosis and got no further workup.
Also, artemisinins can potentially cause hypokalaemia. They have been known to affect voltage-gated potassium currents, and their administration in patients of hypokalaemia has been known to prolong the QT-interval. Hara et al. examined the effect of artemisinins on ligandgated potassium currents and found an inhibitory effect [17]. Development of immunity, increasing resistance to antimalarial drugs and indiscriminate use of antimalarial drugs have also been proposed as the causes for malaria presenting with unusual features in endemic areas [18].
The authors believe that in this case the patient developed hypokalaemia most likely due to a distributional shift of potassium, which was potentiated by the drugs he received before his hospitalization. However, he did not have any similar response to the artemisinins after admission (artesunate IV) and after discharge (artemether po).

Conclusion
Physicians, especially those in endemic areas of malaria, must consider motor weakness being caused by complications secondary to infectious diseases, especially a prevalent one like malaria. Potassium levels must be monitored in a case presenting with such symptoms.
Once the presence of hypokalaemia in a case has been established, the authors recommend the following approach: to determine its cause to fully evaluate and investigate the patient to treat the hypokalaemia (aggressively, if lifethreatening) and its complications to treat the malaria to treat the underlying cause/trigger of the hypokalaemia.
A thorough neurological examination must be done to determine the extent of the weakness and its type (whether flaccid or spastic) and associated features. An ECG must be quickly obtained as well. The patient's fluid status must be evaluated to rule out hypovolaemia and urine output must be monitored. Arterial blood gas should be tested to evaluate alkalosis, anion gap and bicarbonate levels. Magnesium and calcium deficiency must also be ruled out. Persistent weakness despite potassium correction and normalization of its values could warrant EMG/NCV, imaging and CSF tests. Thyroid profile should also be done to exclude periodic paralysis.
From the existing literature, it is clear that hypokalaemia and hyponatremia are now well documented phenomena in malaria patients. However, the actual incidence of hypokalaemia and its associated clinical manifestations may be highly underestimated. Further studies are required to determine its epidemiology and pathophysiology.

Patient's consent
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.