Ref. | Subjects & Regimen | Cmax (ng/mL) | Tmax (hours) | Clearance (L/kg/hr) | Volume (L/kg) | Half-life (hours) | AUC (ng*hr/mL) |
---|---|---|---|---|---|---|---|
[49] Sirivichay et al, 2007 | 16 paediatric patients with uncomplicated falciparum malaria 10 mg/kg (n = 7) or 20 mg/kg (n = 9) AS as rectal suppositories | 898; 1535†a | 1.5; 2.0a |  |  | 1.3; 1.8a | 2403; 5633†a |
[50] Halpaap et al, 1998 | 12 paediatric patients with uncomplicated falciparum malaria 50 mg AS as rectal suppository [0.86 - 2.55 mg/kg AS] | 180†| 1.13 |  |  |  |  |
[42] Awad et al, 2004 | 12 healthy Sudanese adults 200 mg AS as rectal suppository | 219.1†| 1.95 |  |  | 1.21 | 1185.17 |
[30] Navaratnam et al, 1998 | 12 healthy Malaysian adults 200 mg AS as rectal suppository | 385.6†| 1.80 |  |  |  | AUC0-t 965 |
Krishna et al, 2001 [15] | 34 Ghanaian children (8 months - 7 years) with moderate falciparum malaria Group 1: AS 10 mg/kg as rectal suppository, IV AS 2.4 mg/kg 12 hr later Group 2: AS 20 mg/kg AS as rectal suppository, IV AS 2.4 mg/kg 12 hr later Group 3: 2.4 mg/kg IV AS, 20 mg/kg AS as rectal suppository 12 hr later | Group 1: 682†a Group 2 & 3: 881†a | Group 1: 1.7a Tlag: 0.63a Group 2 & 3: 1.8a Tlag: 0.37a | Group 1: 2.6 Group 2 & 3: 3.9 | Group 1: 4.4a Group 2 & 3: 5.9a | Group 1: 0.79a Group 2 & 3: 0.85a | Group 1: 2787 †a Group 2 & 3: 3753†a |