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  1. Research

    Identification of a novel merozoite surface antigen of Plasmodium vivax, PvMSA180

    Although a number of Plasmodium vivax proteins have been identified, few have been investigated as potential vaccine candidates. This study characterized the Plasmodium vivax merozoite surface antigen 180 (PvMSA1...

    Fauzi Muh, Jin-Hee Han, Myat Htut Nyunt, Seong-Kyun Lee, Hye-Yoon Jeon, Kwon-Soo Ha, Won Sun Park, Seok-Ho Hong, Md Atique Ahmed, Sunghun Na, Eizo Takashima, Takafumi Tsuboi and Eun-Taek Han

    Malaria Journal 2017 16:133

    Published on: 28 March 2017

  2. Research

    Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon

    Chloroquine had been used extensively during the last five decades in Cameroon. Its decreasing clinical effectiveness, supported by high proportions of clinical isolates carrying the mutant pfcrt haplotype (CVIET...

    Nicaise Tuikue Ndam, Leonardo K. Basco, Vincent Foumane Ngane, Ahidjo Ayouba, Eitel Mpoudi Ngolle, Philippe Deloron, Martine Peeters and Rachida Tahar

    Malaria Journal 2017 16:130

    Published on: 27 March 2017

  3. Research

    A novel in vitro model reveals distinctive modulatory roles of Plasmodium falciparum and Plasmodium vivax on naïve cell-mediated immunity

    To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and...

    Setthakit Chitsanoor, Sangdao Somsri, Panyu Panburana, Mathirut Mungthin, Ratawan Ubalee, Maliwan Emyeam, Somchai Jongwutiwes, Jetsumon Sattabongkot and Rachanee Udomsangpetch

    Malaria Journal 2017 16:131

    Published on: 27 March 2017

  4. Research

    Predictors of the use of interventions to prevent malaria in pregnancy in Cameroon

    Malaria in pregnancy is common in sub-Saharan Africa where it contributes to perinatal morbidity and mortality. Use of insecticide-treated bed nets and intermittent preventive therapy with sulfadoxine–pyrimeth...

    Jodie Dionne-Odom, Andrew O. Westfall, Tobias O. Apinjoh, Judith Anchang-Kimbi, Eric A. Achidi and Alan T. N. Tita

    Malaria Journal 2017 16:132

    Published on: 27 March 2017

  5. Research article

    Analytical sensitivity of current best-in-class malaria rapid diagnostic tests

    Rapid diagnostic tests (RDTs) are today the most widely used method for malaria diagnosis and are recommended, alongside microscopy, for the confirmation of suspected cases before the administration of anti-ma...

    Alfons Jimenez, Roxanne R. Rees-Channer, Rushini Perera, Dionicia Gamboa, Peter L. Chiodini, Iveth J. González, Alfredo Mayor and Xavier C. Ding

    Malaria Journal 2017 16:128

    Published on: 24 March 2017

  6. Case report

    Diagnostic challenges and case management of the first imported case of Plasmodium knowlesi in Sri Lanka

    Sri Lanka has achieved ‘malaria-free’ status and is now in the phase of prevention of re-introduction of malaria. Imported malaria remains a challenge to resurgence of the disease. The diagnostic challenges en...

    A. Dewanee Ranaweera, Manjula N. Danansuriya, Kusumawathie Pahalagedera, W. M. Kumudunayana T. de A. W. Gunasekera, Priyani Dharmawardena, Keng Wai Mak, Pei-Sze Jeslyn Wong, Mei-Zhi Irene Li, Cheong Huat Tan, Hapuarachchige C. Hapuarachchi, Hema D. B. Herath and Deepika Fernando

    Malaria Journal 2017 16:126

    Published on: 21 March 2017

  7. Research

    Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda

    Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcr...

    Stephen Tukwasibwe, Patrick Tumwebaze, Melissa Conrad, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Samuel L. Nsobya, Bryan Greenhouse and Philip J. Rosenthal

    Malaria Journal 2017 16:125

    Published on: 21 March 2017

  8. Research

    False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

    Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a dele...

    Christina T. Kozycki, Noella Umulisa, Stephen Rulisa, Emil I. Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema and Donald J. Krogstad

    Malaria Journal 2017 16:123

    Published on: 20 March 2017

  9. Research

    Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

    Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To o...

    Marlena Maziarz, Tobias Kinyera, Isaac Otim, Paul Kagwa, Hadijah Nabalende, Ismail D. Legason, Martin D. Ogwang, Samuel Kirimunda, Benjamin Emmanuel, Steven J. Reynolds, Patrick Kerchan, Moses M. Joloba, Andrew W. Bergen, Kishor Bhatia, Ambrose O. Talisuna, Robert J. Biggar…

    Malaria Journal 2017 16:124

    Published on: 20 March 2017

  10. Research

    Clinical and molecular surveillance of drug resistant vivax malaria in Myanmar (2009–2016)

    One of the major challenges for control and elimination of malaria is ongoing spread and emergence of drug resistance. While epidemiology and surveillance of the drug resistance in falciparum malaria is being ...

    Myat Htut Nyunt, Jin-Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong-Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han and Eun-Taek Han

    Malaria Journal 2017 16:117

    Published on: 16 March 2017

  11. Research

    Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015

    In response to increasing resistance to anti-malarial drugs, Senegal adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria in 2006. However, resistance of Plasm...

    Silman Diawara, Marylin Madamet, Mame Bou Kounta, Gora Lo, Khalifa Ababacar Wade, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Mamadou Wague Gueye, Bécaye Fall, Bakary Diatta and Bruno Pradines

    Malaria Journal 2017 16:118

    Published on: 16 March 2017

  12. Research

    Comparison of the diagnostic performance of microscopic examination with nested polymerase chain reaction for optimum malaria diagnosis in Upper Myanmar

    Accurate diagnosis of Plasmodium infection is crucial for prompt malaria treatment and surveillance. Microscopic examination has been widely applied as the gold standard for malaria diagnosis in most part of mala...

    Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim and Byoung-Kuk Na

    Malaria Journal 2017 16:119

    Published on: 16 March 2017

  13. Research

    Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78

    To assess the effect on malaria prevalence, village specific monthly administrations of pyrimethamine, chlorproguanil, chloroquine or placebo were given to children in four previously treatment-naïve Liberian ...

    Irina T. Jovel, Anders Björkman, Cally Roper, Andreas Mårtensson and Johan Ursing

    Malaria Journal 2017 16:113

    Published on: 13 March 2017

  14. Research

    TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon

    Toll-interacting protein is a negative regulator in the TLR signaling cascade, particularly by impeding the TLR2 and, TLR4 pathway. Recently, TOLLIP was shown to regulate human TLR signaling pathways. Two common

    Larissa W. Brasil, Laila R. A. Barbosa, Felipe J. de Araujo, Allyson G. da Costa, Luan D. O. da Silva, Suzana K. Pinheiro, Anne C. G. de Almeida, Andrea Kuhn, Sheila Vitor-Silva, Gisely C. de Melo, Wuelton M. Monteiro, Marcus V. G. de Lacerda and Rajendranath Ramasawmy

    Malaria Journal 2017 16:116

    Published on: 13 March 2017

  15. Research

    Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

    Non-human primates, such as the rhesus macaques, are the preferred model for down-selecting human malaria vaccine formulations, but the rhesus model is expensive and does not allow for direct efficacy testing ...

    Timothy W. Phares, Anthony D. May, Christopher J. Genito, Nathan A. Hoyt, Farhat A. Khan, Michael D. Porter, Margot DeBot, Norman C. Waters, Philippe Saudan and Sheetij Dutta

    Malaria Journal 2017 16:115

    Published on: 13 March 2017

  16. Review

    A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria

    Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding...

    Mirjam Groger, Hannah S. Fischer, Luzia Veletzky, Albert Lalremruata and Michael Ramharter

    Malaria Journal 2017 16:112

    Published on: 11 March 2017

  17. Research

    Resting and feeding preferences of Anopheles stephensi in an urban setting, perennial for malaria

    The Indian city of Chennai is endemic for malaria and the known local malaria vector is Anopheles stephensi. Plasmodium vivax is the predominant malaria parasite species, though Plasmodium falciparum is present a...

    Shalu Thomas, Sangamithra Ravishankaran, N. A. Johnson Amala Justin, Aswin Asokan, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B. Thomas and Alex Eapen

    Malaria Journal 2017 16:111

    Published on: 10 March 2017

  18. Research

    Prevalence and determinants of malaria among children in Zambézia Province, Mozambique

    Malaria is the leading cause of death among children in Mozambique. Prevalence and factors associated with malaria are not well studied among children in rural Zambézia Province. Whether prevalence of malaria ...

    James G. Carlucci, Meridith Blevins Peratikos, Charlotte B. Cherry, Melanie L. Lopez, Ann F. Green, Lazaro González-Calvo and Troy D. Moon

    Malaria Journal 2017 16:108

    Published on: 9 March 2017

  19. Research

    Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

    Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G...

    Anna Caroline C. Aguiar, Flávio Jr. B. Figueiredo, Patrícia D. Neuenfeldt, Tony H. Katsuragawa, Bruna B. Drawanz, Wilson Cunico, Photini Sinnis, Fidel Zavala and Antoniana U. Krettli

    Malaria Journal 2017 16:110

    Published on: 9 March 2017

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