Ref. | Subjects & Regimen | Cmax (ng/mL) | Tmax (hours) | Half-life (hours) | AUC (ng*hr/mL) |
---|---|---|---|---|---|
[49] Sirivichay et al, 2007 | 16 paediatric patients with uncomplicated falciparum malaria 10 mg/kg (n = 7) or 20 mg/kg (n = 9) AS as rectal suppositories | 507; 561†a | 0.8; 1.0a | 0.9; 0.9a | 692; 1076†a |
[50] Halpaap et al, 1998 | 12 paediatric patients with uncomplicated falciparum malaria 50 mg AS as rectal suppository [0.86 - 2.55 mg/kg AS] | 90†| 0.58 |  |  |
[30] Navaratnam et al, 1998 | 12 healthy Malaysian adults 200 mg AS as rectal suppository | 448.5 | 1.43 | 0.95 | 796 |