From: Use of mefloquine in children - a review of dosage, pharmacokinetics and tolerability data
Authority/Expert Group | MQ Chemoprophylaxis in children | MQ Therapy of uncomplicated malaria including Stand-by emergency self treatment (SBET) in children |
---|---|---|
WHO International Travel and Health [1] | Mefloquine recommended for chemoprophylaxis for children weighting > 5 kg. Dosage 5 mg/kg/week | Treatment of uncomplicated malaria in children weighing > 5 kg. Dosage 25 mg/kg as split dose (15 mg/kg followed by 10 mg/kg 6-24 hours apart) |
DTG [48] Deutsche Tropenmed. Gesellschaft | Mefloquine recommended for chemoprophylaxis for children weighing > 5 kg. Dosage 5 mg/kg/week | No longer routinely recommended for SBET |
Canadian Guidelines CATMAT[49] | Mefloquine recommended for chemoprophylaxis in travellers > 5 kg body weight (5 mg/kg once weekly)-start 3 weeks before travel | Not routinely recommended for SBET |
 | 5-10 kg 1/8 Tablet |  |
 | 10-20 kg ¼ Tablet |  |
 | 20-30 kg 1/2 Tablet |  |
 | 30-35 kg ¾ Tablet |  |
 | > 45 kg 1 tablet |  |
CDC [50] | Begin 1-2 weeks before travel | Not routinely recommended for SBET |
 | ≤ 9 kg (5 mg/kg salt once weekly) |  |
 | > 9 kg-19 kg ¼ Tablet once weekly |  |
 | > 19-30 kg 1/2 Tablet once weekly |  |
 | > 31-45 kg ¾ Tablet once weekly |  |
 | > 45 kg 1 Tablet once weekly |  |
UK Guidelines [51] | Weekly mefloquine | Not routinely recommended for SBET |
 | < 6 kg not recommended |  |
 | 6-9.9 kg ¼ Tablet weekly |  |
 | 10-15.9 kg ¼ Tablet weekly |  |
 | 16-24.9 kg 1/2 Tablet weekly |  |
 | 25-44.9 kg ¾ Tablet weekly |  |
 | 45 kg and over 1 Tablet weekly |  |
French Guidelines [53] | Mefloquine 5 mg/kg per week. | Not routinely recommended for SBET |
 | Start 10 days before travel, take throughout the exposure period and for 3 weeks thereafter |  |
 | < 15 kg not recommended |  |
 | 15-19 kg: ¼ Tablet weekly |  |
 | 19-30 kg: 1/2 Tablet weekly |  |
 | 30-45 kg: ¾ Tablet weekly |  |