Table 1 General characteristics on admission

Median age (range), y

Adult (n = 65)

Child (n = 3)

Men, n (%)

Continent of birth, n (%)

Europe

Africa

Other

Immunity status*, n (%)

Non-immune

Partially immune

Semi immune

Chemoprophylaxis, n (%)

Adequate

Inadequate

   Absent

   Inappropriate

Unknown

Indication for artesunate, n (%)

Severe malaria^§ (> 1 of the following criteria)

Impaired consciousness

Multiple convulsions (> 2 episodes/24 h)

Respiratory distress or pulmonary edema

Shock (systolic blood pressure < 70 mm Hg)

Haemoglobinuria

Abnormal bleeding

Hypoglycaemia (glucose < 2.2. mmol/L)

Acidaemia (pH < 7.25)

Acidosis (plasma bicarbonate < 15 mmol/L)

Anaemia (Hb < 3.1 mmol/l or haematocrit < 15%)

Hyperparasitaemia (> 5%)

Hyperlactataemia (lactate > 5 mmol/L)

Renal impairment (creatinine > 265 μmol/L)

Jaundice (bilirubin > 50 μmol/L)

Non severe malaria on admission

Clinical deterioration to severe malaria

Parasitaemia between 2-5%

Unable to take oral medication^†

Other^‡