| Authors | Year of publication | Location City (State) | PCR confirmation | Age range (in years) | Number of patients | Type of clinical complication | Pregnancy | Death | Co-morbidity |
---|---|---|---|---|---|---|---|---|---|---|
1 | Urbaez-Brito JD [80] | 1995 | Costa Marques (Rondônia) | No | NA | 35 | Jaundice | No | No | HBV |
2 | Alecrim MGC [81] | 2000 | Manaus (Amazonas) | Yes | > 18 | 426 | Thrombocytopaenia, bleeding and DIC | No | Yes (1) | NA |
3 | Neves, JJO [82] | 2002 | Belém (Pará) | No | NA | 127 | Thrombocytopaenia | No | No | NA |
4 | Marques HO [83] | 2004 | Manaus (Amazonas) | No | 15-75 | 106 | Thrombocytopaenia and coagulation disorders | No | No | NA |
5 | Oliveira MS [84] | 2004 | Manaus (Amazonas) | No | 0-11 | 69 | Anaemia | No | No | Intestinal helminthes |
6 | Silva IBA [85] | 2004 | Belém (Pará) | No | > 15 | 83 | Thormbocytopaenia and TNF | No | No | NA |
7 | Raposo CCBS [86] | 2006 | Buriticupu (Maranhão) | No | 1-70 | 140 | Jaundice, anaemia, thrombocytopaenia, acute renal failure, ARDS, bleeding and neurological symptoms | No | No | No |
8 | Pereira MSS [87] | 2006 | Manaus (Amazonas) | No | NA | 76 | Jaundice | Yes | No | NA |
9 | Guerreiro NSV [88] | 2006 | Macapá (Amapá) | No | 25-39 | 35 | Anaemia | No | No | NA |
10 | Lacerda MVG [89] | 2007 | Manaus (Amazonas) | Yes | > 18 | 142 | Thrombocytopaenia and bleeding | No | No | No |
11 | Silva SBR [90] | 2009 | Cuiabá (Mato Grosso) | No | NA | 397 | Thrombocytopaenia | No | No | NA |
12 | Fragoso SCP [91] | 2010 | Manaus (Amazonas) | Yes | 1-88 | 17 | Autopsies series (acute lung oedema, shock, blackwater fever, spleen haematoma rupture) | No | Yes (17) | Pneumonia, G6PD deficiency, chronic hepatitis, HIV and yellow fever |
13 | Lança EFC [92] | 2011 | Manaus (Amazonas) | No | 0-14 | 24 | Anaemia, shock, ARDS, coma, jaundice, blackwater fever, metabolic acidosis and hypoglycaemia | No | Yes (2) | Malnutrition, gastroenteritis, sepsis, G6PD deficiency |