Fractions /Compounds | Solvent system | P. falciparum W2- IC50±SD (μg/ml) | Falcipain-2 IC50±SD (μg/ml) |
---|---|---|---|
SJFR1 | 6.24±1.01 | 8.22±1.09 | |
SJFR2 | Hex:EtOAc 10% | 11.55±2.45 | 6.02±3.81 |
SJFR3 | >10 | >10 | |
SJFR4 | >10 | 21.90 ±1.85 | |
SJFR5 | Hex:EtOAc 25% | >10 | >10 |
SJFR6 | >10 | >10 | |
SJFR7 | >10 | >10 | |
SJFR8 | 2.76±0.08 | >10 | |
SJFR9 | 2.30±0.97 | 5.42±0.65 | |
SJFR10 | Hex:EtOAc 50/50 | 2.46±0.29 | >10 |
SJFR11 | >10 | >10 | |
SJFR12 | >10 | >10 | |
SJFR13 | >10 | >10 | |
SJFR14 | >10 | >10 | |
SJFR15 | Hex:EtOAc 75% | >10 | 17.31±2.51 |
SJFR16 | >10 | >10 | |
SJFR17 | 8.47±0.41 | 1.12±0.16 | |
SJFR18 | EtOAc 100% | >10 | 1.14±0.10 |
CQ | 0.05±0.01 | ||
ART | 0.007±0.01 | ||
E64 | ND | 0.049±0.003 | |
2,3,6-trihydroxy benzoic acid (1) | 16.47±0.47 μM | 35.41±22.37μM | |
2,3,6-trihydroxy methyl benzoate (2) | 13.04±1.63 μM | 6.09±0.87 μM |