Parameter name | Value in simulations | Variable name | Quantity measured |
---|---|---|---|
n PfEMP1 | 300-1000 | t asexual | Time remaining in current asexual cycle |
n minor | 20-100 | N i | Number of IRBCs of type i |
n MSP | 4-100 | X i | Density of IRBCs of type i per μL |
X 50,innate | 1000/μL | Y capacity,f(i) | Non-dimensional capacity to mount antibody response to variant f(i) |
Ï„ innate | 0.5 days | Y antibody,f(i) | Non-dimensional antibody response to variant f(i) |
k fever | 2 C | Y innate | Non-dimensional level of inflammatory cytokines |
X 50,antibody | 10/μL | Y fever | Fever in degrees C |
Ï„ capacity | 10 days | Y MSP,j | Adaptive immune response to MSP variant j |
k antibodymin | 0.01 | N i+j,i | Number of IRBCs of type i with progeny expressing type i + j |
k minormod | 0.5 | Z MS | Success probability of merozoite invasion |
C innate | 0.2 | N gametocytes,i | Number of gametocytes of stage i |
C antibody | 1.5 | X gametocytes,mature | Mature female gametocytes per μL |
c minormod | 0.3 | P kill,i | Probability of clearing IRBC of type i |
Ï„ abdecay | 20 days | P infect | Probability of successfully infecting mosquito |
Y memory | Varies up to 0.3 | Â | Â |
K MSP | 0.02 | Â | Â |
K antigen | 5e-9 | Â | Â |
n antigenswitch | 7 | Â | Â |
k gametocyte | 0.1 | Â | Â |
C merozoite | 0.5 | Â | Â |
N IRBCmerozoites | 16 | Â | Â |
T asexual | 2 days | Â | Â |
Z success | 0.01 | Â | Â |
Y gam,50 | 0.05 | Â | Â |