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Table 4 Seropositivity rates and GMTs for anti-CS antibodies from Months 0 to 20 (ATP Cohort for Immunogenicity)

From: Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a malaria-endemic region

Group

Timing

N

Seropositive

GMT (EU/mL)

  
   

n

%

95% CI

 

value

95% CI

 

RTS,S/AS02D

SCREENING

141

33

23.4

16.7

31.3

0.3

0.3

0.4

 

Post Dose 2 (Month 2)

151

149

98.7

95.3

99.8

28.9

22.4

37.3

 

Post Dose 3 (Month 3)

143

141

98.6

95.0

99.8

69.5

53.9

89.6

 

Post Dose 3 (Month 9)

143

127

88.8

82.5

93.5

6.2

4.6

8.3

 

Post Dose 3 (Month 14)

142

107

75.4

67.4

82.2

3.0

2.2

4.0

 

Post Dose 3 (Month 20)

131

94

71.8

63.2

79.3

1.9

1.4

2.6

Hepatitis B

SCREENING

152

39

25.7

18.9

33.4

0.4

0.3

0.4

vaccine

Post Dose 2 (Month 2)

156

10

6.4

3.1

11.5

0.3

0.3

0.3

 

Post Dose 3 (Month 3)

144

2

1.4

0.2

4.9

0.3

0.2

0.3

 

Post Dose 3 (Month 9)

147

0

0.0

0.0

2.5

0.3

0.3

0.3

 

Post Dose 3 (Month 14)

139

2

1.4

0.2

5.1

0.3

0.2

0.3

 

Post Dose 3 (Month 20)

132

5

3.8

1.2

8.6

0.3

0.3

0.3

  1. Seropositive ≥ 0.5 EU/mL.
  2. N = number of subjects with available results.
  3. n/% = number/percentage of subjects with titre within the specified range.