Population pharmacokinetics of mefloquine, piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients

Table 1 Dosing regimens of the study drugs

Drug	Body weight [kg]	Age [years]	Day 0	Day 1	Day 2
AM-LF	5–14		AM: 2 × 20 mg	AM: 2 × 20 mg	AM: 2 × 20 mg
AM-LF	5–14		LF: 2 × 120 mg	LF: 2 × 120 mg	LF: 2 × 120 mg
	15–24		AM: 2 × 40 mg	AM: 2 × 40 mg	AM: 2 × 40 mg
	15–24		LF: 2 × 240 mg	LF: 2 × 240 mg	LF: 2 × 240 mg
	25–34		AM: 2 × 60 mg	AM: 2 × 60 mg	AM: 2 × 60 mg
	25–34		LF: 2 × 360 mg	LF: 2 × 360 mg	LF: 2 × 360 mg
	≥35		AM: 2 × 80 mg	AM: 2 × 80 mg	AM: 2 × 80 mg
	≥35		LF: 2 × 480 mg	LF: 2 × 480 mg	LF: 2 × 480 mg
AS-MQ	10–12.5		AS: 50 mg	AS: 50 mg	AS: 50 mg
AS-MQ	10–12.5		MQ: 125 mg	MQ: 125 mg
	13–15.5		AS: 50 mg	AS: 50 mg	AS: 50 mg
	13–15.5		MQ: 125 mg	MQ: 125 mg	MQ: 125 mg
	16–24.5		AS: 100 mg	AS: 100 mg	AS: 100 mg
	16–24.5		MQ: 250 mg	MQ: 250 mg
	25–34.5		AS: 150 mg	AS: 150 mg	AS: 150 mg
	25–34.5		MQ: 250 mg	MQ: 250 mg	MQ: 250 mg
	35–37		AS: 200 mg	AS: 200 mg	AS: 200 mg
	35–37		MQ: 250 mg	MQ: 250 mg	MQ: 250 mg
	38–57		AS: 200 mg	AS: 200 mg	AS: 200 mg
	38–57		MQ: 500 mg	MQ: 500 mg	MQ: 250 mg
	58–76		AS: 200 mg	AS: 200 mg	AS: 200 mg
	58–76		MQ: 500 mg	MQ: 500 mg	MQ: 500 mg
DHA-PPQ		6–11	DHA: 60 mg	DHA: 60 mg	DHA: 40 mg
DHA-PPQ		6–11	PPQ: 480 mg	PPQ: 480 mg	PPQ: 320 mg
		11–16	DHA: 80 mg	DHA: 80 mg	DHA: 80 mg
		11–16	PPQ: 640 mg	PPQ: 640 mg	PPQ: 640 mg
		>16	DHA: 120 mg	DHA: 120 mg	DHA: 80 mg
		>16	PPQ: 960 mg	PPQ: 960 mg	PPQ: 640 mg

Abbreviations: AM artemether, AS artesunate, DHA dihydroartemisinin, LF lumefantrine, MQ mefloquine, PPQ piperaquine.

ISSN: 1475-2875