Networking the host immune response in Plasmodium vivax malaria

Malaria Journal

Table 4 Distribution of chemokines and other proteins levels in the study subjects stratified by Plasmodium vivax malaria clinical outcome

Biomaker	Endemic controls	Asymptomatic malaria	Symptomatic malaria	Severe malaria: Survivors	Severe malaria: Deaths	P value	P value
Biomaker	Endemic controls	Asymptomatic malaria	Symptomatic malaria	Severe malaria: Survivors	Severe malaria: Deaths	1	2
	n=176	n=148	n=187	n=13	n=6
CCL2	86.0	85.2	65.8	64.7	87.9	0.117	0.207
ng/mL	(21-176)	(18-161.6)	(23.0-145.6)	(43-127)	(34.7-139)	0.117	0.207
CCL5	27.0	24.4	25. 3	26.1	36.7	0.007	0.156
μg/mL	(15-45.7)	(13.4-38)	(15.8-70.2)	(20-38.7)	(25.4-83.2)	0.007	0.156
CXCL9	0.3	0.5	2.2	3.5	4.6	<0.001	<0.001
ng/mL	(0.2-0.5)	(0.3-0.8)	(0.4-9.4)	(0. 6-12.5)	(0.8-9.9)	<0.001	<0.001
CXCL10	88.0	19.4	77.4	117.7	183.3	<0.001	<0.001
pg/mL	(25-198)	(10.2-25.0)	(25.3-360.7)	(28-564)	(30.0-395.5)	<0.001	<0.001
sTNF-RI	0.2	0.5	0.6	0.8	2.2	<0.001	<0.001
ng/mL	(0.1-0.4)	(0.4-0.6)	(0.4-0.7)	(0.7-0.9)	(1.7-3.1)	<0.001	<0.001
SOD-1	4.2	6.0	26.0	72.6	82.4	<0.001	<0.001
ng/mL	(2.6-6.8)	(3.6-10)	(18.8-34.0)	(71-80.4)	(76.6-100.5)	<0.001	<0.001
HO-1	29.1	29.5	35.5	42.9	49.2	<0.001	<0.001
ng/mL	(25.8-32)	(26.3-35.2)	(29.7-44.8)	(38.5-45)	(48.4-57.3)	<0.001	<0.001

Note: Data represent median values and interquartile ranges. P value 1 was obtained using Kruskal-Wallis test, whereas P value 2 was calculated using Linear trend post test.

ISSN: 1475-2875