Adverse event | PA | MQ + AS | AL | CQ | All comparators |
---|---|---|---|---|---|
 | (n = 2815) | (n = 423) | (n = 603) | (n = 228) | (n = 1254) |
Any adverse event | 1611 (57.2) | 190 (44.9) | 384 (63.7) | 72 (31.6) | 646 (51.5) |
Blood and lymphatic system disorders | |||||
Anaemia | 128 (4.5) | 17 (4.0) | 18 (3.0) | 1 (0.4) | 36 (2.9) |
Basophilia | 9 (0.3) | 9 (2.1) | 1 (0.2) | 0 | 10 (0.8) |
Eosinophilia | 101 (3.6) | 5 (1.2) | 27 (4.5) | 4 (1.8) | 36 (2.9) |
Lymphocytosis | 21 (0.7) | 0 | 16 (2.7) | 0 | 16 (1.3) |
Neutropenia | 55 (2.0) | 0 | 27 (4.5) | 0 | 27 (2.2) |
Gastrointestinal disorders | |||||
Abdominal pain | 98 (3.5) | 7 (1.7) | 31 (5.1) | 2 (0.9) | 40 (3.2) |
Diarrhoea | 41 (1.5) | 9 (2.1) | 6 (1.0) | 2 (0.9) | 17 (1.4) |
Vomiting | 124 (4.4) | 9 (2.1) | 23 (3.8) | 7 (3.1) | 39 (3.1) |
General disorders | |||||
Fatigue | 49 (1.7) | 6 (1.4) | 3 (0.5) | 11 (4.8) | 20 (1.6) |
Influenza-like illness | 49 (1.7) | 0 | 21 (3.5) | 0 | 21 (1.7) |
Pyrexia | 66 (2.3) | 4 (0.9) | 18 (3.0) | 2 (0.9) | 24 (1.9) |
Infections and infestations | |||||
Bronchitis | 52 (1.8) | 6 (1.4) | 12 (2.0) | 3 (1.3) | 21 (1.7) |
Nasopharyngitis | 74 (2.6) | 11 (2.6) | 8 (1.3) | 6 (2.6) | 25 (2.0) |
Rhinitis | 19 (0.7) | 2 (0.5) | 12 (2.0) | 0 | 14 (1.1) |
Upper RTI | 100 (3.6) | 4 (0.9) | 31 (5.1) | 0 | 35 (2.8) |
Urinary tract infection | 34 (1.2) | 3 (0.7) | 12 (2.0) | 1 (0.4) | 16 (1.3) |
Investigations | |||||
AST increased | 63 (2.2) | 1 (0.2) | 14 (2.3) | 0 | 15 (1.2) |
Blood albumin decreased | 21 (0.7) | 0 | 16 (2.7) | 0 | 16 (1.3) |
Blood CPK increased | 26 (0.9) | 4 (0.9) | 3 (0.5) | 8 (3.5) | 15 (1.2) |
Blood glucose decreased | 33 (1.2) | 0 | 19 (3.2) | 0 | 19 (1.5) |
ECG QT prolongation | 6 (0.2) | 5 (1.2) | 1 (0.2) | 6 (2.6) | 12 (1.0) |
Eosinophil count increased | 58 (2.1) | 6 (1.4) | 2 (0.3) | 0 | 8 (0.6) |
Platelet count increased | 59 (2.1) | 3 (0.7) | 20 (3.3) | 0 | 23 (1.8) |
Metabolism and nutrition disorders | |||||
Anorexia | 85 (3.0) | 13 (3.1) | 10 (1.7) | 10 (4.4) | 33 (2.6) |
Musculoskeletal and connective tissue disorders | |||||
Myalgia | 107 (3.8) | 19 (4.5) | 1 (0.2) | 21 (9.2) | 41 (3.3) |
Nervous system disorders | |||||
Dizziness | 39 (1.4) | 28 (6.6) | 1 (0.2) | 6 (2.6) | 35 (2.8) |
Headache | 297 (10.6) | 44 (10.4) | 46 (7.6) | 34 (14.9) | 124 (9.9) |
Respiratory, thoracic and mediastinal disorders | |||||
Cough | 167 (5.9) | 10 (2.4) | 55 (9.1) | 5 (2.2) | 70 (5.6) |