| Base model | Final model |
---|
Parameter | Estimate | SD | Estimate | SD |
---|
Ka (h-1) | 0.166 | 0.0266 | 0.163 | 0.0263 |
CL/F (L/h) | 1.15 | 0.0496 | 1.13 | 0.0501 |
Vc/F (L) | 279 | 14.7 | 271 | 14.1 |
ѲBW,Vc | / | / | 0.87 | 0.288 |
Q/F (L/h) | 1.33 | 0.124 | 1.43 | 0.152 |
Vp/F (L) | 341 | 39 | 344 | 40.6 |
ѲBW,Vp | / | / | 2.41 | 1.08 |
| 0.675 | 0.250 | 0.562 | 0.232 |
| 0.0939 | 0.0224 | 0.0894 | 0.0218 |
| 0.0603 | 0.0209 | 0.0453 | 0.0163 |
| 0.401 | 0.166 | 0.295 | 0.128 |
σ2 | 0.0689 | 0.0150 | 0.0692 | 0.015 |
- SD standard deviation of the estimate (obtained from the covariance step); Ka: absorption rate constant; CL/F: apparent oral clearance; Vc/F: apparent central distribution volume; ѲBW,Vc: influential factor of BW on Vc/F; Q/F: apparent distribution clearance; Vp/F: apparent distribution volume ; ѲBW,Vp : influential factor of BW on Vp/F ; : inter-individual variability of CL/F; : inter-individual variability of Vc/F; : inter-individual variability of Vp/F; : inter-individual variability of Ka; σ2: proportional residual error.