Table 1 Dose-response effects of mefloquine on elevation of cytosolic calcium levels induced via liberation of the ER store.
Concentration in μM (# of experiments) | Relative increase in cytosolic CA2+ due to ER calcium release (range) | Magnitude of effect relative to 200 μM mefloquine (%) |
|---|---|---|
DMSO (4) | 1.0 (1.0–1.0) | 0 |
2 (4) | 1.0 (1.0–1.2) | 2.4 |
10 (4) | 1.1 (1.0–1.2) | 3.6 |
30 (5) | 1.5 (1.2–1.7) | 30 |
60 (4) | 1.9 (1.8–2.6) | 53 |
80 (4) | 2.5 (2.1–2.9) | 74 |
200 (4) | 3.2 (2.6–4.1) | 100 |