Figure 1

Concentration-dependent TB activity of anti-Pfs25 monoclonal antibody 4B7. MAb 4B7 was serially diluted with pooled human O serum to give the antibody concentration in the feed as indicated (X-axis), mixed with mature in vitro-cultured P. falciparum gametocytes and fed to A. stephensi mosquitoes. Approximately one week later, oocysts were counted and % inhibition of oocyst density per mosquito relative to mosquitoes fed with a pooled human O serum is plotted (Y-axis). Line represents regression of result by use of a hyperbolic equation.