Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India

Malaria Journal

Table 1 Clinical characteristics of the study participants

	CATEGORY
CHARACTERISTIC	HC	MM	CMS	CMNS
Total number of subjects	25	48	48	12
Adults (≥ 18 yr)	20	33	32	7
Children (< 18 yr)	5	15	16	5
No of males	18	28	34	6
No of females	7	20	14	6
Median age (yr)	22 ± 14	19 ± 14	25 ± 19	20 ± 16
Mean Glasgow Coma Score	14	14	6.7 ± 2.3	5.08 ± 2.2
Seizures	0	0	16	8
Geomean parasitaemia (pRBC/mm³)	0	1594 ± 426.6	4166 ± 650.9	1336 ± 386.2
Geomean haemoglobin (g/dL)	10.1 ± 0.40	9.17 ± 0.38	7.94 ± 0.37	6.82 ± 0.73
Tribal population	4	4	12	4
Non-tribal population	21	44	36	8
Renal failure	0	0	7	2
Geomean duration of admission (days)	N/A	3.5	6.4	1.8

Clinical study characteristics of the study participants in Jabalpur, India. HC – healthy controls, MM – mild malaria, CMS – cerebral malaria survivors, CMNS – cerebral malaria non-survivors. Relevant clinical data and information (such as duration of coma and seizures) were recorded for each patient from physician's records. Venous blood samples from children (2 – 5 ml) and adults (10 ml) were collected soon after enrolment into the study at the hospital from HC, MM, CMS, and CMNS groups prior to commencement of anti-malarial treatment or transfusions. Plasma was separated after centrifugation in Becton-Dickinson cell preparation tubes and aliquoted and frozen at -80°C for long-term storage.

ISSN: 1475-2875