Table 1 Genetic diversity in the gene encoding apical membrane antigen-1 (AMA1) before and after immunization with a bivalent AMA1 malaria vaccine
From: Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
| Â | Number of sequences | Number of haplotypes | Haplotype diversity (Hd) | Nucleotide diversity (Ï€) | Average number of nucleotide differences (k) | Tajima D | Tajima D p-value |
|---|---|---|---|---|---|---|---|
Control group | Â | Â | Â | Â | Â | Â | Â |
   Baseline | 23 | 22 | 0.996 | 0.0163 | 19.672 | 0.3308 | > 0.1 |
   Post-immunization | 129 | 96 | 0.993 | 0.0172 | 20.729 | 1.4110 | > 0.1 |
   Control total | 152 | 112 | 0.994 | 0.0179 | 20.726 | 0.9110 | > 0.1 |
AMA1 vaccine group | Â | Â | Â | Â | Â | Â | Â |
   Baseline | 21 | 21 | 1.000 | 0.0176 | 21.210 | 0.2413 | > 0.1 |
   Post-immunization | 142 | 94 | 0.989 | 0.0172 | 20.773 | 1.8010 | > 0.05 |
   AMA1 vaccine total | 163 | 106 | 0.990 | 0.0172 | 20.792 | 1.0150 | > 0.1 |