Figure 9

Proposed model for the trafficking and maturation of PfA-M1 in infected erythrocytes. PfA-M1 is targeted to the secretory pathway and the trafficking to the Golgi is sensitive to brefeldin A. The p120 is secreted into the vacuolar space where it undergoes proteolytic processing to yield the p96 form which is endocytosed within the double membrane of the cytostome and taken back into the parasite. The p96 is further processed to the p68 form which is targeted towards the digestive food vacuole, where it is marginally delivered.