Figure 3

P. yoelii is far less pro-inflammatory than P. falciparum. P. yoelii non lethal XNL 1.1 strain was injected i.p. in NOD/SCID mice and the same parameters as in P. falciparum infected mice were assessed (see the legend of figure 2). (A) Peripheral blood parasitaemia; (B) Total number of leukocyte per μl of blood (plain circle) at different time post-infection. The numbers of CD11b⁺ F4/80⁺ monocytes (black square, line dot) and CD11b⁺ Ly-6G⁺ PMN (white triangle) were calculated from the percentages obtained by FACS analysis. The percentage of CD43^- CD62L⁺ Ly-6C⁺ inflammatory monocytes was also assessed by FACS (open circle, dotted line); (C) Cytokines/chemokine levels determined using the CBA mouse inflammatory cytokines kit. Results represent the means ± SEM from 2 distinct experiments (n = 5 mice).