Step | Enzyme name | Enzyme number | P. falciparum homologuesa | Syntenic orthologsb |
---|---|---|---|---|
1 | Hexokinase (HK) | EC 2.7.1.1 | PF3D7_0624000 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
2 | Glucose-6-phosphate isomerase (G6PI) | EC 5.3.1.9 | PF3D7_1436000 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
3 | Glucosamine-fructose-6-phosphate aminotransferase (GFPT) | EC 2.6.1.16 | PF3D7_1025100 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
4 | Glucosamine-phosphate N- acetyltransferase (GNA) | EC 2.3.1.4 | No gene identified | Â |
5 | Phosphoacetylglucosamine mutase (PAGM) | EC 5.4.2.3 | PF3D7_1130000 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
6 | UDP-N-acetylglucosamine pyrophosphorylase (UAP) | EC 2.7.7.23 | PF3D7_1343600 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
7 | Mannose-6-phosphate isomerase (MPI) | EC 5.3.1.8 | PF3D7_0801800 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
8 | Phosphomannomutase (PMM) | EC 5.4.2.8 | PF3D7_1017400 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
9 | Mannose-1-phosphate guanyltransferase (MPG) | EC 2.7.7.13 | PF3D7_1420900 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
10 | GDP-mannose 4,6-dehydratase (GMD) | EC 4.2.1.47 | PF3D7_0813800 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
11 | GDP-L-fucose synthase (FS) | EC 1.1.1.271 | PF3D7_1014000 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
12 | Phosphoglucomutase (PGM) | EC 5.4.2.2 | PF3D7_1012500 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
13 | UTP-glucose-1-phosphate uridylyltransferase (UGP) or UDP-sugar pyrophosphorylase (USP) | EC 2.7.7.9 or EC 2.7.7.64 | PF3D7_0517500 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
14 | Galactokinase (GK) | EC 2.7.1.6 | No gene identified | Â |
15 | UDP-glucose 4-epimerase (GALE) | EC 5.1.3.2 | No gene identified | Â |
16 | Dolichol-phosphate mannosyltransferase polypeptide 1 (DPM1) | EC 2.4.1.83 | PF3D7_1141600 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
Enzymes involved in GPI-Anchor biosynthesis | ||||
17 | Â phosphatidylinositol n- acetylglucosaminyltransferase (PIG-A) | EC 2.4.1.198 | PF3D7_0618900.1 and PF3D7_0935300 and/or PF3D7_1032400 and/or PF3D7_1141400 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
18 | Â N-acetylglucosaminyl phosphatidylinositol deacetylase (PIG-L) | EC 3.5.1.89 | PF3D7_0624700 and/or PF3D7_0911000 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
19 | Â Inositol acyltransferase (PIG-W) | EC 2.3 | PF3D7_0615300 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
20 | Â GPI mannosyltransferase I (PIG-M) | EC 2.4.1 | PF3D7_1210900 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
21 | Â GPI mannosyltransferase II (PIG-V) | EC 2.4.1 | PF3D7_1247300 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
22 | Â GPI mannosyltransferase III (PIG-B) | EC 2.4.1 | PF3D7_1341600 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
23 | Â GPI mannosyltransferase IV | EC 2.4.1 | No gene identified | Â |
Enzymes involved in N-glycans biosynthesis | ||||
24 | Â UDP-N-Acetyl-glucosamine-1-P transferase (ALG7) | EC 2.7.8.15 | PF3D7_0321200 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
25 | Â UDP-N-Acetylglucosaminyltransferase subunit (ALG13) | EC 2.4.1.141 | PF3D7_0806400 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
26 | Â UDP-N-Acetylglucosaminyltransferase subunit (ALG14) | EC 2.4.1.141 | PF3D7_0211600 | Pv, Pk, Pr, Pb, Py, Pch |
27 | Â Catalytic subunit of the oligosaccharyltransferase complex (STT3) | EC 2.4.99.18 | PF3D7_1116600 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
Enzymes involved in O-fucosylation | ||||
28 | Â GDP-fucose protein O-fucosyltransferase 2 (PoFUT2) | EC 2.4.1.221 | PF3D7_0909200 | Pv, Pk, Pc, Pr, Pb, Py, Pch |
Enzymes involved in C-mannosylation | ||||
29 | Â C-mannosyltransferase | EC 2.4.1 | PF3D7_0806200 | Pv, Pk, Pc, Pr, Pb, Py, Pch |