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Table 6 Estimated country-level impact of RTS,S vaccination per 100,000 vaccinees

From: Potential public health impact of RTS,S malaria candidate vaccine in sub-Saharan Africa: a modelling study

Country

Median (95 % CI)

Clinical malaria cases averted

Severe malaria cases averted

Malaria hospitalizations averted

Malaria deaths averted

Vaccination at 6, 10 and 14 weeks

 Burkina Faso

34,861 (310, 70,852)

621 (−1016, 2154)

516 (−844, 1789)

162 (−265, 562)

 Democratic Republic of Congo

27,132 (3581, 51,194)

640 (−1014, 1887)

532 (−843, 1567)

167 (−265, 493)

 Ghana

24,435 (2400, 46,521)

551 (−1098, 1610)

458 (−912, 1337)

144 (−287, 420)

 Kenya

6773 (845, 13,316)

197 (−424, 691)

164 (−353, 574)

51 (−111, 181)

 Nigeria

31,252 (2923, 60,259)

693 (−1133, 2124)

576 (−941, 1764)

181 (−296, 555)

 Tanzania

13,604 (1973, 25,448)

345 (−744, 1031)

287 (−618, 857)

90 (−194, 269)

 Senegal

7671 (1548, 14,331)

314 (−710, 1022)

261 (−590, 849)

82 (−185, 267)

 Uganda

28,104 (800, 56,058)

511 (−976, 1652)

425 (−811, 1372)

134 (−255, 431)

 42 countries in sub-Saharan Africa

19,851 (1884, 38,413)

471 (−852, 1480)

391 (−708, 1229)

123 (−222, 386)

Vaccination at 6, 7.5 and 9 months

 Burkina Faso

115,124 (67,076, 137,011)

2042 (−11, 4048)

1697 (−9, 3363)

533 (−3, 1057)

 Democratic Republic of Congo

91,161 (59,510, 106,849)

1864 (82, 3499)

1549 (68, 2907)

487 (21, 914)

 Ghana

86,586 (59,758, 101,564)

1524 (15, 2857)

1267 (13, 2374)

398 (4, 746)

 Kenya

25,005 (18,192, 29,522)

542 (−61, 1100)

450 (−51, 914)

141 (−16, 287)

 Nigeria

104,755 (66,626, 123,236)

2078 (67, 3948)

1727 (56, 3280)

543 (17, 1031)

 Tanzania

50,152 (37,252, 58,652)

901 (−33, 1712)

748 (−27, 1422)

235 (−9, 447)

 Senegal

29,478 (23,357, 34,505)

796 (−92, 1580)

661 (−76, 1312)

208 (−24, 412)

 Uganda

96,898 (61,368, 114,643)

1555 (−7, 3012)

1292 (−6, 2502)

406 (−2, 787)

 42 countries in sub-Saharan Africa

68,169 (45,007, 80,249)

1368 (−2, 2631)

1136 (−2, 2186)

357 (−1, 687)

  1. Estimated median and 95 % CIs for the numbers of clinical malaria cases, severe malaria cases, malaria hospitalizations and malaria deaths per 100,000 vaccinees averted by RTS,S vaccination with doses administered either at 6, 10 and 14 weeks or at 6, 7-and-a-half and 9 months
  2. Outcomes are estimated for the annual birth cohort in each country, beginning in 2017 and following the cohort until the age of 10 years, assuming no change in malaria transmission