Malaria Journal

Table 3 Clinical trials of clindamycin plus other drug against P. falciparum malaria

From: Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

Study demographic details					Regimen								Efficacy (%)
Year	Place	Reference	Pop	Nb	Clindamycin			Other drug			Route	Days
Year	Place	Reference	Pop	Nb	Dosage	Form	Nb doses/d	Drug^a	Dosage/d	Nb doses/d	Route	Days
1974	USA	Miller, 1973 [53]	A	5							PO	3	100
1975	USA	Clyde, 1975 [50]	A	5	450 mg	Salt	3	Q	560 mg	3	PO	3	60
1975	USA	Clyde, 1975 [50]	A	2	600 mg	Salt	1	Q	560 mg	3	PO	3	50
1975	Thailand	Hall, 1975 [79]	A	4	450 mg	Salt	3	Q	540 mg	3	PO	3	100
1975	Thailand	Hall, 1975 [79]	A	5	150 mg	Salt	3	Q	270 mg	3	PO	3	60
1987	Brazil	Kremsner, 1988 [20]	A	40	15 mg/kg	Base	2	Q	10 mg/kg	2	PO	3	90
1992	Gabon	Kremsner, 1994 [52]	C	34	5 mg/kg	Base	2	Q	12 mg/kg	2	PO	3	88
1993	Gabon	Metzger, 1995 [89]	C	33	5 mg/kg	Base	2	CQ	25 mg/kg	3	PO	3	70
1995	Gabon	Kremsner, 1995 [90]	C	50	5 mg/kg	Base	3	Q	8 mg/kg	3	IV	4	96
1995	Gabon	Metzger, 1995 [54]	A	40	5 mg/kg	Base	2	Q	12 mg/kg	2	PO	3	92
1996	France	Parola, 2001 [91]	A	53	5 mg/kg	Salt	3	Q	8 mg/kg	3	IV	3	100
1997	Gabon	Vaillant, 1997 [57]	C	161	8 mg/kg	Salt	2	Q	8 mg/kg	2	PO	3	97
2000	Thailand	Pukrittayakamee [92]	A	68	5 mg/kg	Base	4	Q	8 mg/kg	3	PO	7	100
2001	Thailand	McGready, 2001 [5]	P	65	5 mg/kg	Salt	3	Q	8 mg/kg	3	PO	7	100
2004	Gabon	Bormann, 2004 [6]	C	12	10 mg/kg	Salt	2	F	60 mg/kg	2	PO	5	100
2004	Gabon	Ramharter, 2005 [7]	C	100	7 mg/kg	Salt	2	A	2 mg/kg	2	PO	3	87

Randomized controlled trial
Only trials with adequate dosing, i.e. clindamycin given at least twice daily are mentioned in this table
Pop population, A adult, C children, P pregnant women
^a C chloroquine, Q quinine, F fosmidomycin, A artesunate

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ISSN: 1475-2875

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