Fig. 1From: Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infectionsStudy design, parasitaemias and treatment regimens of rhesus macaques infected with Plasmodium cynomolgi sporozoites. a Longitudinal study design to collect whole blood and bone marrow aspirates for current and retrospective analyses at critical infection points as indicated (yellow). b Log10 parasitaemia and treatment regimens for the five rhesus macaques infected with 2000 P. cynomolgi B strain sporozoites on day 0 are shown. Whole blood and bone marrow aspirate sample collections are marked in yellow for each animal and correspond with critical infection points depicted in Panel a and summarized in Table 1. Sub-curative and curative blood-stage treatments were administered as needed based on the clinical complications that occurred during the primary infection and to ensure bona fide relapses. c The mean of the peak parasitaemias for the primary and first relapses of RIc14, RSb14, RMe14, and RFa14 are shown. Statistical significance was assessed by a Wilcoxon-Matched pairs sign rank test; p-values less than 0.05 were considered significantBack to article page