Investigation of mechanisms of bendiocarb resistance in Anopheles gambiae populations from the city of Yaoundé, Cameroon

Table 4 GOTERM categories recorded significantly enriched compare to the reference set (total number of transcripts detected by microarray), terms with a lowest count limit of 2 and an ease score p value <0.05

Category	Go-term functions	FE	p value	Benjamini^a
Overexpressed in resistant vs control
GOTERM_MF_FAT	Peptidase activity acting on L-amino acid peptides	21	0.009	0.21
GOTERM_MF_FAT	Peptidase activity	21	0.011	0.13
GOTERM_MF_FAT	Proteolysis	21	0.024	0.36
Overexpressed in control vs Kisumu
GOTERM_MF_FAT	Electron carrier activity	5	0.001	0.17
SMART	PhBP	1.7	0.0048	0.25
GOTERM_BP_FAT	Oxidation reduction	5.9	0.0062	0.93
SP_PIR_KEYWORDS	Oxidoreductase	4.2	0.0081	0.46
INTERPRO	Cytochrome P450	2.9	0.0092	0.95
SP_PIR_KEYWORDS	Monooxygenase	2.5	0.012	0.36
INTERPRO	Odorant binding protein PhBP	1.7	0.012	0.85
INTERPRO	Pheromone/general odorant binding protein, PBP/GOBP	2.1	0.013	0.76
INTERPRO	Cytochrome P450, conserved site	2.5	0.019	0.79
Overexpressed in resistant vs Kisumu
GOTERM_MF_FAT	electron carrier activity	7	0.00015	0.02
SP_PIR_KEYWORDS	Iron	5.1	0.00072	0.049
INTERPRO	Cytochrome P450	4.5	0.0011	0.22
GOTERM_MF_FAT	Iron ion binding	6.4	0.0017	0.11
SP_PIR_KEYWORDS	Monooxygenase	3.8	0.0021	0.072
SP_PIR_KEYWORDS	Oxidoreductase	5.7	0.0022	0.051
GOTERM_BP_FAT	Oxidation reduction	7.6	0.003	0.58
INTERPRO	Cytochrome P450	3.8	0.0033	0.3
COG_ONTOLOGY	Posttranslational modification, protein turnover, chaperones	4.5	0.005	0.044
SP_PIR_KEYWORDS	Haem	3.8	0.0058	0.097
GOTERM_MF_FAT	Tetrapyrrole binding	4.5	0.0098	0.36
GOTERM_MF_FAT	Haem binding	4.5	0.0098	0.36

ISSN: 1475-2875