Table 1 Number and prevalence of Plasmodium falciparum polymorphisms pre- and post-treatment and post-treatment selection
Genotype | Pre-treatment | Post-treatment | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
ASAQ-FDC | AL | |||||||||
Recrudescences | Reinfections | Recrudescences | Reinfections | |||||||
pfcrt 76 | ||||||||||
K | 19 | 6.5 % | 0 | 0.0 % | 2 | 3.3 % | 1 | 16.7 % | 12*** | 31.6 % |
K/T | 7 | 2.4 % | 0 | 0.0 % | 3 | 5.0 % | 0 | 0.0 % | 1 | 2.6 % |
T | 268 | 91.2 % | 2 | 100.0 % | 55 | 91.7 % | 5 | 83.3 % | 25 | 65.8 % |
pfmdr1 86 | ||||||||||
N | 90 | 30.6 % | 1 | 50.0 % | 12 | 19.7 % | 4 | 66.7 % | 28*** | 70.0 % |
N/Y | 47 | 16.0 % | 0 | 0.0 % | 8 | 13.1 % | 1 | 16.7 % | 3 | 7.5 % |
Y | 157 | 53.4 % | 1 | 50.0 % | 41 | 67.2 % | 1 | 16.7 % | 9 | 22.5 % |
pfmdr1 184 | ||||||||||
Y | 166 | 56.5 % | 1 | 50.0 % | 33 | 55.9 % | 3 | 50.0 % | 24 | 55.8 % |
Y/F | 24 | 8.2 % | 1 | 50.0 % | 2 | 3.4 % | 1 | 16.7 % | 2 | 4.7 % |
F | 104 | 35.4 % | 0 | 0.0 % | 24 | 40.7 % | 2 | 33.3 % | 17 | 39.5 % |
pfmdr1 1246 | ||||||||||
D | 181 | 61.6 % | 2 | 66.7 % | 29 | 48.3 % | 5 | 83.3 % | 33 | 76.7 % |
D/Y | 58 | 19.7 % | 1 | 33.3 % | 7 | 11.7 % | 0 | 0.0 % | 2 | 4.7 % |
Y | 55 | 18.7 % | 0 | 0.0 % | 24** | 40.0 % | 1 | 16.7 % | 8 | 18.6 % |
pfmrp1 876 | ||||||||||
I | 285 | 96.9 % | 2 | 100.0 % | 59 | 96.7 % | 6 | 100.0 % | 42 | 97.7 % |
I/V | 7 | 2.4 % | 0 | 0.0 % | 1 | 1.6 % | 0 | 0.0 % | 0 | 0.0 % |
V | 2 | 0.7 % | 0 | 0.0 % | 1 | 1.6 % | 0 | 0.0 % | 1 | 2.3 % |
pfmrp1 1466 | ||||||||||
K | 283 | 96.3 % | 3 | 100.0 % | 60 | 100.0 % | 6 | 100.0 % | 40 | 100.0 % |
K/R | 4 | 1.4 % | 0 | 0.0 % | 0 | 0.0 % | 0 | 0.0 % | 0 | 0.0 % |
R | 7 | 2.4 % | 0 | 0.0 % | 0 | 0.0 % | 0 | 0.0 % | 0 | 0.0 % |
pfmdr1 86 + 184 + 1246 a | ||||||||||
NYD | 55 | 27.8 % | 1 | 100.0 % | 5 | 10.2 % | 2 | 40.0 % | 15 | 42.9 % |
NYY | 0 | 0 % | 0 | 0 % | 2* | 4.1 % | 0 | 0 % | 1 | 2.9 % |
NFD | 29 | 14.6 % | 0 | 0.0 % | 4 | 8.2 % | 2 | 40.0 % | 10* | 28.6 % |
YFD | 54 | 27.3 % | 0 | 0.0 % | 15 | 30.6 % | 0 | 0.0 % | 1 | 2.9 % |
YYY | 47 | 23.7 % | 0 | 0.0 % | 20* | 40.8 % | 1 | 20.0 % | 5 | 14.3 % |
Othersb | 13 | 6.6 % | 0 | 0.0 % | 3 | 6.1 % | 0 | 0.0 % | 3 | 8.6 % |