Clinical criteria | Laboratory criteria |
---|---|
Loss of consciousness or profound coma | Haemoglobinuria |
Prostration; extreme weakness with inability to walk or sit without assistance | Hypoglycaemia (<60 mg/dL) |
Inability to feed oneself | Metabolic acidosis (plasmatic bicarbonate <15 mmol/L) |
Multiple seizures; more than 1 episode in 24 h | Hyperlactaemia (lactate acid <5 mmol/L) |
Respiratory distress syndrome | Severe anaemia (haemoglobin <7 g/dL, haematocrit <21 %) |
Circulatory collapse/shock; systolic arterial pressure <80 mmHg in adults and <50 mmHg in children | Hyperparasitaemia (>50,000 asexual parasites/μL) with the diagnosis of P. falciparum, or mixed infection with P. vivax |
Clinical jaundice with signs of vital organ failure | Thrombocytopaenia (<50,000 mm3) |
Spontaneous haemorrhage | Elevated transaminase (>80 IU)* |
Pulmonary oedema evidenced through radiography | Elevated total bilirubin (>1.5 mg/dL) Renal insufficiency (serum creatinine level >1.5 mg/dL) |