Table 4 Clinical characteristics of falciparum malaria patients

G6PD variant

Orissa

Orissa^b

Kerala-Kalyan^b

–

–

Florescent spot test 0 h

Deficient

ND

Intermediate

64 N/10 I/1 D

75

47 N/13 I

60

Demographics

 Age (years)

27

32

55

28 (22–40)

77

28 (21–35)

61

0.8468

 Sex (%, M)

M

F

F

49 (64%)

77

42 (69%)

61

 Previous malaria

Y

N

N

16 (21%)

76

21 (34%)

61

0.191

 Days of fever

10

13

30

7 (6–10)

77

7 (4–10)

61

0.0656

 Blackwater fever

N

N

N

16 (21%)

77

2 (3%)

61

<0.0001

 Severity of disease

UM

SM

UM

–

–

–

–

Physical examination

 Temperature (°C)

40.0

36.8

37.0

38.2 (37.5–39.2)

77

38.2 (37.2–39.4)

61

0.89

 Glasgow coma score

15

15

15

9 (8–14)

77

15 (15–15)

61

 Respiratory rate (per min)

40

32

28

36 (28–44)

77

26 (22–32)

61

<0.00001

 Splenomegaly

N

N

N

16 (21%)

77

7 (11%)

61

N = 37/33

Laboratory parameters

 Parasite count per μl^a

171,821

10,425

2520

100,229 (15,826–353,690)

77

22,244 (1200–102,615)

61

0.0006

 PfHRP2 (mg/ml)

384

1297

172

3036 (1497–9946)

71

563 (143–1300)

57

<0.0001

 CFH (μM)

1.4

1.6

0.9

5.3 (2.5–12.7)

75

2.0 (1.3–3.6)

57

<0.0001

 Haemoglobin (g/dl)

10.9

5.3

7.8

8.9 (7.0–10.9)

77

11.6 (8.9–13.2)

61

<0.0001

 LDH (U/l)

141

967

275

643 (526–912)

77

322 (230–383)

28

<0.0001

 Total bilirubin (mg/dl)^a

1.4

1.4

0.6

2.0 (1.0–3.3)

77

1.0 (0.7–1.6)

60

0.0001

 Creatinine (mg/dl)

1.1

4.5

1.1

1.4 (1.1–2.9)

77

1.2 (1.0–1.4)

60

0.0002

 Urine pH

5.06

5.00

6.45

5.57 (5.28–5.83)

57

6.00 (5.62–6.43)

36

0.0004

 pH

7.47

7.37

7.39

7.38 (7.32–7.43)

77

7.44 (7.40–7.47)

61

<0.0001

 Bicarbonate (mmol/l)

19.8

13.9

22.6

17.3 (14.6–19.5)

77

21.4 (19.6–23.5)

61

<0.0001

 pCO₂ (mmHg)

28

24

37

29 (25–33)

77

32 (28–35)

61

0.0024

 Lactate (mmol/l)

2.11

0.71

1.94

3.9 (2.3–6.1)

77

1.6 (1.2–2.1)

61

<0.0001